stockrowKrystal Biotech, Inc.
KRYS Healthcare Biotechnology
Krystal Biotech, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $389.1 million, up 33.9% from fiscal 2024.
- Revenue
- +30.2%
- EPS
- −22.3%
- Free cash flow
- +137.8%
Quarter to September 2026, against a year earlier
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Krystal Biotech, Inc. (KRYS) Operating margin
Krystal Biotech, Inc.'s operating margin over the twelve months to 30 September 2026 was 48.4%, up 7.0 percentage points from fiscal 2025 (41.5%). Over the past ten years it has ranged from −216.2% (fiscal 2023) to 41.5% (fiscal 2025) — the current reading is the highest in ten years. That is above the Biotechnology industry median of 0.00% and above the Healthcare sector median of 0.00%.
Operating margin, annual
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Annual newest first
| Period | Operating margin | Change (points) |
|---|---|---|
| FY2025 | 41.5% | 18.82 |
| FY2024 | 22.6% | 238.84 |
| FY2023 | −216.2% | (216.21) |
| FY2022 | 0.00% | 0.00 |
| FY2021 | 0.00% | 0.00 |
| FY2020 | 0.00% | 0.00 |
| FY2019 | 0.00% | 0.00 |
| FY2018 | 0.00% | 0.00 |
| FY2017 | 0.00% | 0.00 |
| FY2016 | 0.00% | — |
Quarterly newest first
| Period | Operating margin | Change (points) |
|---|---|---|
| Sep 2026 | 55.9% | 6.87 |
| Jun 2026 | 49.0% | 2.86 |
| Mar 2026 | 46.1% | 4.81 |
| Dec 2025 | 41.3% | (0.97) |
| 36 more quarters | Free account |
Against its own ten years
Operating margin against peers
| Company | Operating margin |
|---|---|
| KRYS Krystal Biotech, Inc. | 48.4% |
| PTGX Protagonist Therapeutics, Inc. compare | 20.7% |
| TGTX TG Therapeutics, Inc. compare | 17.1% |
| CAI Caris Life Sciences,�Inc. compare | 13.4% |
| SYRE Spyre Therapeutics, Inc. compare | 0.00% |
| MDGL Madrigal Pharmaceuticals, Inc. compare | −10.7% |
| TWST Twist Bioscience Corporation compare | −33.6% |
| IBRX ImmunityBio, Inc. compare | −151.9% |
| CYTK Cytokinetics, Incorporated compare | −625.2% |
| Biotechnology industry median | 0.00% |
| Healthcare sector median | 0.00% |
| Market median | 0.00% |
What Operating margin is
EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.
EBIT ÷ Revenue
More on KRYS
- Revenue
- Net income
- EPS (diluted)
- EBITDA
- Free cash flow
- Operating cash flow
- Gross margin
- Net margin
- Free cash flow margin
- P/E ratio
- P/S ratio
- P/B ratio
- Price to free cash flow
- EV/EBITDA
- EV/Sales
- EV/FCF
- Return on equity
- Return on assets
- Return on invested capital
- Debt to equity
- Current ratio
- Total debt
- Shares outstanding
- Book value per share
- Altman Z-score
- The full statement