Krystal Biotech, Inc. (KRYS) vs Protagonist Therapeutics, Inc. (PTGX)

Krystal Biotech, Inc. and Protagonist Therapeutics, Inc. are both Biotechnology companies. Krystal Biotech, Inc. and Protagonist Therapeutics, Inc. are of similar size ($8.9B and $8.8B). Krystal Biotech, Inc. trades at the lower P/E: 39.2× against 111×. Protagonist Therapeutics, Inc. grew revenue faster over the last twelve months: 34.8% against 26.0%. Krystal Biotech, Inc. has the higher net margin (47.9% vs 29.4%) and the lower return on invested capital (27.2% vs 61.8%). Across the 19 metrics below, Krystal Biotech, Inc. leads on 15 and Protagonist Therapeutics, Inc. on 4.

Valuation

Metric KRYS PTGX Biotechnology median
P/E 39.21 110.95 10.26
P/S 18.92 31.65 9.18
P/B 6.20 10.61 2.05
Price to free cash flow 28.68 68.35 24.81
EV/EBITDA 34.07 144.60 0.65
EV/Sales 16.98 28.91 8.98
Earnings yield 2.55% 0.90% (34.89%)
Free cash flow yield 3.49% 1.46% (24.52%)

Profitability

Metric KRYS PTGX Biotechnology median
Gross margin 94.27% 100.00% 65.16%
Operating margin 48.41% 20.69% 0.00%
Net margin 47.91% 29.40% 0.00%
Free cash flow margin 65.97% 46.31% 0.00%
Return on equity 17.50% 10.98% (50.12%)
Return on assets 15.93% 10.34% (45.60%)
Return on invested capital 27.15% 61.84% 0.00%

Growth

Metric KRYS PTGX Biotechnology median
Revenue growth (TTM) 25.96% 34.81% 6.26%
EPS growth (last fiscal year) 128.00% (148.46%) 29.88%
Revenue growth, 5-year CAGR — 9.96% 9.75%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric KRYS PTGX Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 7.89 21.71 4.89
Net debt to EBITDA (4.93) 3.49 1.01

Dividend

Metric KRYS PTGX Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric KRYS PTGX Biotechnology median
Market cap 8.90b 8.75b 172.11m

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