Krystal Biotech, Inc. (KRYS) vs Protagonist Therapeutics, Inc. (PTGX)

Krystal Biotech, Inc. and Protagonist Therapeutics, Inc. are both Biotechnology companies. Krystal Biotech, Inc. is the larger, with a market value of $10.2B against $8.9B — 1.1× the size. Krystal Biotech, Inc. trades at the lower P/E: 41.9× against 117×. Protagonist Therapeutics, Inc. grew revenue faster over the last twelve months: 34.8% against 22.6%. Krystal Biotech, Inc. has the higher net margin (54.8% vs 29.4%) and the lower return on invested capital (24.1% vs 61.8%). Across the 19 metrics below, Krystal Biotech, Inc. leads on 15 and Protagonist Therapeutics, Inc. on 4.

Valuation

Metric KRYS PTGX Biotechnology median
P/E 41.86 116.99 7.88
P/S 23.21 33.37 11.47
P/B 7.52 11.18 2.52
Price to free cash flow 39.65 72.07 21.16
EV/EBITDA 45.87 153.05 0.74
EV/Sales 21.29 30.60 10.73
Earnings yield 2.39% 0.85% (28.84%)
Free cash flow yield 2.52% 1.39% (23.03%)

Profitability

Metric KRYS PTGX Biotechnology median
Gross margin 94.64% 100.00% 65.16%
Operating margin 44.89% 20.69% 0.00%
Net margin 54.82% 29.40% 0.00%
Free cash flow margin 58.52% 46.31% 0.00%
Return on equity 20.12% 10.98% (57.72%)
Return on assets 18.30% 10.34% (49.22%)
Return on invested capital 24.07% 61.84% 0.00%

Growth

Metric KRYS PTGX Biotechnology median
Revenue growth (TTM) 22.63% 34.81% 5.64%
EPS growth (last fiscal year) 128.00% (148.46%) —
Revenue growth, 5-year CAGR — 9.96% 8.40%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric KRYS PTGX Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 8.32 21.71 4.73
Net debt to EBITDA (4.93) 3.49 0.96

Dividend

Metric KRYS PTGX Biotechnology median
Dividend yield — — 2.10%
Payout ratio 0.00 0.00 0.00

Size

Metric KRYS PTGX Biotechnology median
Market cap 10.21b 8.88b 162.10m

Compare with another peer

Any metric, up to five companies and an Excel export Powerpack