stockrowProtagonist Therapeutics, Inc.
PTGX Healthcare Biotechnology
Protagonist Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, down 89.4% from fiscal 2024.
- Revenue
- +3,749.2%
- EPS
- +549.1%
- Free cash flow
- +839.7%
Quarter to June 2026, against a year earlier
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Protagonist Therapeutics, Inc. (PTGX) Operating margin
Protagonist Therapeutics, Inc.'s operating margin over the twelve months to 30 June 2026 was 20.7%, up 364.3 percentage points from fiscal 2025 (−343.6%). Over the past ten years it has ranged from −34,857.6% (fiscal 2019) to 58.2% (fiscal 2024); the current reading is higher than 36% of that period. That is above the Biotechnology industry median of 0.00% and above the Healthcare sector median of 0.00%.
Operating margin, annual
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Annual newest first
| Period | Operating margin | Change (points) |
|---|---|---|
| FY2025 | −343.6% | (401.83) |
| FY2024 | 58.2% | 214.29 |
| FY2023 | −156.1% | 338.15 |
| FY2022 | −494.2% | (34.23) |
| FY2021 | −460.0% | (234.65) |
| FY2020 | −225.4% | 34,632.22 |
| FY2019 | −34,857.6% | (34,720.90) |
| FY2018 | −136.7% | 52.21 |
| FY2017 | −188.9% | (188.89) |
| FY2016 | 0.00% | 0.00 |
Quarterly newest first
| Period | Operating margin | Change (points) |
|---|---|---|
| Jun 2026 | 74.4% | 80.84 |
| Mar 2026 | −6.47% | 670.62 |
| Dec 2025 | −677.1% | 308.08 |
| Sep 2025 | −985.2% | (227.13) |
| 40 more quarters | Free account |
Against its own ten years
Operating margin against peers
| Company | Operating margin |
|---|---|
| KRYS Krystal Biotech, Inc. compare | 48.4% |
| PTGX Protagonist Therapeutics, Inc. | 20.7% |
| TGTX TG Therapeutics, Inc. compare | 17.1% |
| CAI Caris Life Sciences,�Inc. compare | 13.4% |
| SYRE Spyre Therapeutics, Inc. compare | 0.00% |
| MDGL Madrigal Pharmaceuticals, Inc. compare | −10.7% |
| TWST Twist Bioscience Corporation compare | −33.6% |
| IBRX ImmunityBio, Inc. compare | −151.9% |
| CYTK Cytokinetics, Incorporated compare | −625.2% |
| Biotechnology industry median | 0.00% |
| Healthcare sector median | 0.00% |
| Market median | 0.00% |
What Operating margin is
EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.
EBIT ÷ Revenue
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