stockrowSpyre Therapeutics, Inc.
SYRE Healthcare Biotechnology
Spyre Therapeutics, Inc.’s revenue for fiscal 2023 (year ended December 2023) was $886,000.00, down 62.0% from fiscal 2022.
- EPS
- −624.8%
- Free cash flow
- −108.8%
Quarter to September 2026, against a year earlier
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Spyre Therapeutics, Inc. (SYRE) Operating margin
Spyre Therapeutics, Inc.'s operating margin over the twelve months to 30 September 2026 was 0.00%, down 0.0 percentage points from fiscal 2025 (0.00%). Over the past ten years it has ranged from −27,348.0% (fiscal 2023) to 0.00% (fiscal 2025) — the current reading is the highest in ten years. That is in line with the Biotechnology industry median of 0.00% and in line with the Healthcare sector median of 0.00%.
Operating margin, annual
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Annual newest first
| Period | Operating margin | Change (points) |
|---|---|---|
| FY2025 | 0.00% | 0.00 |
| FY2024 | 0.00% | 27,347.97 |
| FY2023 | −27,348.0% | (23,707.74) |
| FY2022 | −3,640.2% | (3,289.90) |
| FY2021 | −350.3% | (350.33) |
| FY2020 | 0.00% | 0.00 |
| FY2019 | 0.00% | 1,169.32 |
| FY2018 | −1,169.3% | (637.60) |
| FY2017 | −531.7% | (58.38) |
| FY2016 | −473.3% | (287.39) |
Quarterly newest first
| Period | Operating margin | Change (points) |
|---|---|---|
| Sep 2026 | 0.00% | 0.00 |
| Jun 2026 | 0.00% | 0.00 |
| Mar 2026 | 0.00% | 0.00 |
| Dec 2025 | 0.00% | 0.00 |
| 43 more quarters | Free account |
Against its own ten years
Operating margin against peers
| Company | Operating margin |
|---|---|
| KRYS Krystal Biotech, Inc. compare | 48.4% |
| PTGX Protagonist Therapeutics, Inc. compare | 20.7% |
| TGTX TG Therapeutics, Inc. compare | 17.1% |
| CAI Caris Life Sciences,�Inc. compare | 13.4% |
| SYRE Spyre Therapeutics, Inc. | 0.00% |
| MDGL Madrigal Pharmaceuticals, Inc. compare | −10.7% |
| TWST Twist Bioscience Corporation compare | −33.6% |
| IBRX ImmunityBio, Inc. compare | −151.9% |
| CYTK Cytokinetics, Incorporated compare | −625.2% |
| Biotechnology industry median | 0.00% |
| Healthcare sector median | 0.00% |
| Market median | 0.00% |
What Operating margin is
EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.
EBIT ÷ Revenue
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- Revenue
- Net income
- EPS (diluted)
- EBITDA
- Free cash flow
- Operating cash flow
- Gross margin
- Net margin
- Free cash flow margin
- P/E ratio
- P/S ratio
- P/B ratio
- Price to free cash flow
- EV/EBITDA
- EV/Sales
- EV/FCF
- Return on equity
- Return on assets
- Return on invested capital
- Debt to equity
- Current ratio
- Total debt
- Shares outstanding
- Book value per share
- Revenue growth
- Piotroski F-score
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- The full statement