Krystal Biotech, Inc.

KRYS Healthcare Biotechnology

Krystal Biotech, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $389.1 million, up 33.9% from fiscal 2024.

Revenue
+30.2%
EPS
−22.3%
Free cash flow
+137.8%

Quarter to September 2026, against a year earlier

300.31 0.06 +0.02%
Market cap
$8.9B
P/E
39.2×
Fwd P/E
45.7×
Dividend yield
—
F-score
7/9
Altman Z
39.03
Beneish M
−2.27
Dividend safety
n/a

Krystal Biotech, Inc. (KRYS) Return on equity

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Krystal Biotech, Inc.'s return on equity over the twelve months to 30 September 2026 was 17.5%, down 1.4 percentage points from fiscal 2025 (18.9%). Over the past ten years it has ranged from −32.8% (fiscal 2017) to 18.9% (fiscal 2025) — the current reading is the highest in ten years. That is above the Biotechnology industry median of −50.1% and above the Healthcare sector median of −26.3%.

Return on equity, annual

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Annual newest first

Period Return on equity Change (points)
FY2025 18.9% 8.57
FY2024 10.3% 8.66
FY2023 1.68% 26.77
FY2022 −25.1% (9.38)
FY2021 −15.7% (2.71)
FY2020 −13.0% (0.92)
FY2019 −12.1% 1.31
FY2018 −13.4% 19.37
FY2017 −32.8% (28.00)
FY2016 −4.76% —

Against its own ten years

Low −32.8% High 18.9%
Ten-year median −12.5%
Current reading's percentile 100

Return on equity against peers

Company Return on equity
CYTK Cytokinetics, Incorporated compare 184.7%
IBRX ImmunityBio, Inc. compare 122.9%
TGTX TG Therapeutics, Inc. compare 100.3%
KRYS Krystal Biotech, Inc. 17.5%
PTGX Protagonist Therapeutics, Inc. compare 11.0%
CAI Caris Life Sciences,�Inc. compare 0.00%
MDGL Madrigal Pharmaceuticals, Inc. compare −24.8%
TWST Twist Bioscience Corporation compare −29.6%
SYRE Spyre Therapeutics, Inc. compare −41.2%
Biotechnology industry median −50.1%
Healthcare sector median −26.3%
Market median 0.51%

What Return on equity is

ROE shows how much profit a company earns for its shareholders on the equity they have in the business.

Annual: Net Income Allotted to Shareholders ÷ Average Common Equity; TTM: Net Income Allotted to Shareholders ÷ Average Common Equity (latest quarter)

The full definition of Return on equity →

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