Krystal Biotech, Inc. (KRYS) vs Vaxcyte, Inc. (PCVX)

Krystal Biotech, Inc. and Vaxcyte, Inc. are both Biotechnology companies. Krystal Biotech, Inc. and Vaxcyte, Inc. are of similar size ($9.8B and $8.9B). Vaxcyte, Inc. has negative trailing earnings, so its P/E is not meaningful; Krystal Biotech, Inc. trades at 39.2×. Krystal Biotech, Inc. has the higher net margin (47.9% vs 0.00%) and the higher return on invested capital (27.2% vs −59.5%). Across the 14 metrics below, Krystal Biotech, Inc. leads on 13 and Vaxcyte, Inc. on 1.

Valuation

Metric KRYS PCVX Biotechnology median
P/E 39.21 n/m 10.60
P/S 18.92 n/m 9.40
P/B 6.19 3.82 2.13
Price to free cash flow 28.68 n/m 25.18
EV/EBITDA 34.07 n/m 0.66
EV/Sales 16.98 n/m 9.02
Earnings yield 2.55% (12.64%) (32.88%)
Free cash flow yield 3.49% (10.25%) (23.13%)

Profitability

Metric KRYS PCVX Biotechnology median
Gross margin 94.27% 0.00% 68.51%
Operating margin 48.41% 0.00% 0.00%
Net margin 47.91% 0.00% 0.00%
Free cash flow margin 65.97% 0.00% 0.00%
Return on equity 17.50% (42.68%) (51.96%)
Return on assets 15.93% (37.28%) (46.06%)
Return on invested capital 27.15% (59.47%) 0.00%

Growth

Metric KRYS PCVX Biotechnology median
Revenue growth (TTM) 25.96% — 6.76%
EPS growth (last fiscal year) 128.00% (48.16%) 29.88%
Revenue growth, 5-year CAGR — — 9.75%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric KRYS PCVX Biotechnology median
Debt to equity 0.00 0.04 0.00
Current ratio 7.89 4.56 4.97
Net debt to EBITDA (4.93) 1.71 1.01

Dividend

Metric KRYS PCVX Biotechnology median
Dividend yield — — 0.41%
Payout ratio — — —

Size

Metric KRYS PCVX Biotechnology median
Market cap 8.90b 9.75b 161.82m

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