Praxis Precision Medicines, Inc. PRAX

280.78 (1.01) (0.36%) as of 25 Sep
Market cap
$7.9B
P/E
0.0×

Insider Decisions

Total sells 44.27
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — —
Sell 1 2 — — — — — — 1 — — —
Insider Ownership 9.86%

Capital & Financial Ratios

Market Cap 7,870.00
Revenue 8.55
Net Income (339.13)
Free Cash Flow (306.16)
Net Debt (758.55)
Current Ratio 15.73
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 956.32
P/B ratio 6.10
Past 5Y EPS Growth 8.54%
This Y EPS Growth (0.86%)
Next Y EPS Growth 27.13%
Next 5Y EPS Growth 16.47%
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 81 393 599 759
Receivables — — — —
Inventory — — — —
Other — — — —
85 404 611 772
2023 2024 2025 Q'26
Payables 6 13 25 23
ST’ Debt — — — —
Other — — — —
16 38 60 49
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — —
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 25.03% 125.97%

Revenue

Mar Jun Sep Dec Year
’26 — — — — —
’24 0 0 0 7 9
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (86) (78) — — —
’25 (53) (55) (65) (76) (249)
’24 (21) (27) (27) (56) (132)
’23 (33) (31) (23) (24) (111)
’22 (54) (57) (45) (29) (185)
’21 (26) (30) (24) (45) (125)
’20 (9) (10) (14) (20) (53)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (86) (79) — — —
’25 (53) (55) (65) (76) (249)
’24 (21) (27) (27) (56) (132)
’23 (33) (31) (23) (24) (111)
’22 (54) (57) (45) (29) (185)
’21 (26) (30) (24) (45) (126)
’20 (9) (10) (14) (20) (53)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (3.20) (2.87) — — —
’25 (3.29) (3.31) (3.36) (3.50) (13.48)
’24 (2.84) (1.74) (2.75) (2.94) (10.21)
’23 (10.64) (7.35) (2.70) (2.97) (18.69)
’22 (22.64) (19.79) (14.39) (13.04) (69.56)
’21 (10.64) (13.19) (14.99) (19.49) (59.07)
’20 (76.67) (105.62) (181.41) (13.04) (117.84)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.4
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — — 358.50 190.65 22.20 11.85 20.50 26.70

Analyst estimates 2026–2028

Powerpack
Low Price
— — — — 877.35 914.27 309.00 78.75 86.93 317.72
High Price
— — — 37 67 139 109 82 116 168
Employees
— — — 0 0 0 0 0 0 0
Revenue/Emp
— — — — — — — 2 9 —
Revenue
— — 0.00% 0.00% 0.00% 0.00% 0.00% 100.00% 100.00% —
Gross Margin
— — (26) (36) (62) (167) (214) (123) (183) (303)
EBT
— — 0.00% 0.00% 0.00% 0.00% 0.00% (5,037.88%) (2,137.48%) 0.00%
EBT Margin
— 0 (27) (36) (62) (167) (214) (123) (183) (303)
Net Income
— — 0 0 0 2 1 0 (5) (3)
Depreciation
— — 0.00 0.00 0.00 0.00 0.00 0.37 0.48 0.00
Revenue/Sh
— — (306.49) (347.98) (117.84) (59.07) (69.56) (18.69) (10.21) (13.48)
Earnings/Sh
— — (239.27) (327.33) (88.15) (43.99) (60.22) (16.85) (7.36) (11.07)
Cash Flow/Sh
— — (0.73) (1.01) 0.00 (0.37) (0.14) (0.01) 0.00 0.00
Capex/Sh
— — (240.00) (328.33) (88.15) (44.36) (60.36) (16.86) (7.36) (11.07)
Free CF/Sh
— — (473.88) (793.42) 481.50 88.57 24.77 10.57 24.88 39.02
Book Value/Sh
— — 0 0 1 3 3 7 18 23
Shares
— — — — — — — 0.00 0.00 —
PE Ratio
— — — — — — — 56.32 161.13 —
PS Ratio
— — — — — — — 1.98 3.09 —
PB Ratio
— — — — — — — 23.10 115.23 —
EV/Sales
— — — — — — — (0.51) (7.47) —
EV/FCF
— — (21) (33) (53) (125) (185) (111) (132) (249)
Op' Cash Flow
— — 0 0 — (1) 0 0 — 0
Capex
— — (21) (34) (53) (126) (185) (111) (132) (249)
FCF
— — 14 39 287 249 76 69 367 551
Working Cap'
— — — 1 1 4 4 — — —
Total Debt
— — (18) (45) (297) (276) (100) (81) (393) (599)
Net Debt
— — (41) (81) 287 251 76 70 445 878
Sh' Equity
— — (294.75%) (120.50%) (40.08%) (56.07%) (104.95%) (121.41%) (64.03%) (42.68%)
ROA
— — 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% (236.57%) (73.12%)
ROIC
— — 47.89% 66.67% (68.13%) (62.07%) (130.94%) (169.13%) (70.98%) (45.83%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2024 · latest quarter Dec 2024

Praxis Precision Medicines, Inc. peers in Biotechnology

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Praxis Precision Medicines, Inc. (PRAX) key facts

  • Praxis Precision Medicines, Inc. (PRAX) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • Praxis Precision Medicines, Inc.’s revenue for fiscal 2024 (year ended December 2024) was $8.6 million, up 249.5% from fiscal 2023.
  • As of September 25, 2026, PRAX traded at $280.78, a market capitalization of $7.9 billion.
  • Return on equity was −45.8% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Praxis Precision Medicines, Inc. (PRAX) Latest News

News by impact score

Fine-tune

13 Aug

3 transcript

Praxis Precision Medicines (PRAX) released its Q2 2026 earnings call transcript covering quarterly financial results, pipeline updates, and strategic outlook. Earnings call details financial metrics and pipeline progress with moderate influence on near-term stock performance.

8 Aug

3

Praxis Precision Medicines is accepting bigger short-term losses to fund long-term central nervous system drug ambitions with its cash reserves. Praxis cash deployment for CNS pipeline creates moderate effects on near-term finances and investor views without guaranteed trajectory shift.

7 Aug

3 transcript

Praxis Precision Medicines held its Q2 2026 earnings call covering quarterly financial results, pipeline updates and operational outlook. Quarterly earnings calls typically provide financial metrics and guidance that influence near-term sentiment without guaranteeing major strategic shifts.

3

Praxis Precision Medicines reported Q2 financial results and pipeline updates during its earnings call, detailing operational progress and strategic priorities for the period. Q2 earnings call details financial metrics and pipeline status that can moderately sway short-term stock sentiment and operational outlook.

6 Aug

4

Praxis Precision Medicines Inc (PRAX) highlighted FDA approvals during its Q2 2026 earnings call. FDA approvals represent major regulatory milestones that can substantially boost the company's market position and investor confidence.

4

Praxis Precision Medicines issued a corporate update and reported second quarter 2026 financial results. Quarterly financial results plus corporate updates frequently trigger major stock moves for clinical-stage biotechs.

15 Jul

3

Praxis Precision Medicines (PRAX) enters into licensing and research collaboration with Remagine Labs. Licensing and research collaboration with Remagine Labs may moderately influence Praxis operations and pipeline.

7 Jul

4

Praxis Precision Medicines partners with Remagine Labs to develop transdermal ulixacaltamide for essential tremor treatment. Strategic collaboration advances improved drug delivery for lead candidate potentially strengthening PRAX competitive position.

29 Jun

3

Praxis Precision Medicines extends the period for Relutrigine treatment of SCN2A and SCN8A developmental and epileptic encephalopathies. Relutrigine period extension supports ongoing SCN2A and SCN8A program development with moderate effects on future pipeline progress.

22 Jun

4

Praxis Precision Medicines stock rises after FDA grants breakthrough therapy designation. FDA breakthrough therapy designation accelerates regulatory path and strengthens pipeline prospects.

4

Praxis Precision Medicines received FDA Breakthrough Therapy Designation for Elsunersen to treat seizures associated with SCN2A developmental and epileptic encephalopathy caused by gain of function variants. FDA Breakthrough Therapy Designation accelerates Elsunersen development and materially lifts Praxis valuation prospects.

14 Jun

4

Praxis Precision Medicines reports mixed POWER1 trial results for PRAX, prompting reassessment of stock valuation and future prospects. Mixed POWER1 trial results directly alter PRAX clinical pipeline progress and market valuation trajectory.

5 Jun

4

Praxis Precision Medicines (PRAX) disclosed findings from its Phase 2/3 POWER1 study. Phase 2/3 trial results directly affect drug development path, regulatory prospects and investor valuation.

3 Jun

4

Praxis Precision Medicines faces a setback with Vormatrigine and reassesses its epilepsy pipeline. Vormatrigine setback directly forces epilepsy pipeline reassessment and alters Praxis Precision Medicines trajectory.

2 Jun

4

Praxis Precision Medicines suffered an unexpected setback in seizure drug development that triggered a sharp stock price decline. Setback directly alters pipeline prospects and triggers material stock decline.

1 Jun

4

Praxis Precision Medicines provided an update on its Vormatrigine program. Vormatrigine program update signals major strategic progress in drug development likely to shift company trajectory and investor sentiment.

4

FDA accepted two CNS NDAs from Praxis Precision Medicines, potentially shifting the investment case for PRAX by advancing regulatory progress on key pipeline assets. FDA acceptance of two NDAs marks a major regulatory milestone likely to drive significant gains in PRAX valuation and pipeline momentum.

3

PRAX shares dropped 12% after hours on a clinical trial setback. Retail investors now focus on potential FDA approvals for the company's other pipeline candidates. Trial setback triggers immediate 12% stock drop yet leaves open recovery path via remaining pipeline candidates.

21 May

3

Investor establishes $5 million position in Praxis Precision Medicines signaling confidence in the company's epilepsy drug pipeline. New stake highlights positive sentiment toward Praxis epilepsy pipeline but represents limited immediate financial or operational shift.

17 May

4

Praxis Precision Medicines has an FDA catalyst on June 30. A fund cut its stake in the company by $7 million. FDA catalyst on June 30 can materially move Praxis stock and long-term outlook.

4

Praxis Precision Medicines stock surged 60% on advancing phase 3 plans for its obesity drug while one fund sold 4.7 million dollars of shares. Phase 3 progress for an obesity drug in a high-demand market signals major potential revenue growth and trajectory shift for Praxis.

4

Praxis Precision Medicines advances FDA NDA submissions for its lead programs while posting wider quarterly losses, prompting questions on whether regulatory momentum can offset mounting cash burn and sustain long-term investor interest in the stock. FDA NDA progress for multiple candidates represents a major regulatory catalyst that could materially shift PRAX's development timeline and valuation despite higher losses.

12 May

4 transcript

Praxis Precision Medicines (PRAX) released Q1 2026 earnings call transcript detailing financial results, pipeline updates, clinical progress, and strategic outlook. Earnings call transcripts disclose quarterly financials, pipeline advancements, and guidance that can significantly sway investor sentiment and PRAX stock trajectory.

8 May

4

Praxis Precision Medicines (PRAX) released Q1 earnings call highlights covering financial results, pipeline updates, and strategic outlook. Q1 earnings call highlights detail financial performance, clinical progress, and cash position, capable of driving major shifts in stock trajectory and investor confidence.

4

Praxis Precision Medicines, Inc. (PRAX) released Q1 2026 earnings call summary detailing financial results, pipeline updates, and strategic outlook. Q1 2026 earnings call summary delivers major financial performance data, clinical progress, and guidance shaping PRAX's trajectory and investor confidence.

7 May

4

Praxis Precision Medicines (PRAX) provided a corporate update and reported first quarter 2026 financial results. Quarterly financial results and corporate update disclose critical pipeline progress, cash position, and strategic shifts impacting PRAX's market performance.

3 May

3

Praxis Precision Medicines aligns executive compensation with ulixacaltamide development progress, positioning incentive design as a potential key competitive edge. Tying pay to ulixacaltamide milestones incentivizes pipeline focus, moderately impacting strategic execution and investor sentiment.

29 Apr

5

Optimism surrounds Praxis Precision Medicines (PRAX) amid potential FDA approval for ulixacaltamide. Potential FDA approval of ulixacaltamide is a game-changing regulatory milestone that could fundamentally redefine PRAX's competitive position and long-term prospects.

27 Apr

4

Praxis Precision Medicines Inc. (PRAX) features a rare triple-catalyst setup in neurology, positioning it for potential breakthroughs in precision treatments. Rare triple-catalyst in neurology indicates major strategic advancements likely to alter PRAX's competitive position and investor sentiment.

21 Apr

4

FDA advances Praxis Precision Medicines' (PRAX) ulixacaltamide, its lead essential tremor candidate, toward further development while investors spotlight the company's valuation gap versus neurology peers. FDA progression of ulixacaltamide marks a major regulatory milestone for PRAX's pipeline, likely boosting investor sentiment and narrowing valuation discrepancies.

stockrow.com/PRAX · Data as of Dec 31, 2024 · For information only; not investment advice. · © 2026 stockrow.com