Krystal Biotech, Inc. (KRYS) vs Madrigal Pharmaceuticals, Inc. (MDGL)

Krystal Biotech, Inc. and Madrigal Pharmaceuticals, Inc. are both Biotechnology companies. Krystal Biotech, Inc. and Madrigal Pharmaceuticals, Inc. are of similar size ($10.6B and $9.8B). Madrigal Pharmaceuticals, Inc. has negative trailing earnings, so its P/E is not meaningful; Krystal Biotech, Inc. trades at 38.3×. Madrigal Pharmaceuticals, Inc. grew revenue faster over the last twelve months: 149.0% against 22.6%. Krystal Biotech, Inc. has the higher net margin (54.8% vs −25.3%) and the higher return on invested capital (24.1% vs −787.3%). Across the 17 metrics below, Krystal Biotech, Inc. leads on 14 and Madrigal Pharmaceuticals, Inc. on 3.

Valuation

Metric KRYS MDGL Biotechnology median
P/E 38.28 n/m 8.50
P/S 21.22 10.21 9.71
P/B 6.88 25.03 2.13
Price to free cash flow 36.26 n/m 20.82
EV/EBITDA 41.59 n/m 0.64
EV/Sales 19.30 9.82 9.21
Earnings yield 2.61% (2.87%) (33.15%)
Free cash flow yield 2.76% (1.60%) (25.50%)

Profitability

Metric KRYS MDGL Biotechnology median
Gross margin 94.64% 91.48% 65.16%
Operating margin 44.89% (25.13%) 0.00%
Net margin 54.82% (25.32%) 0.00%
Free cash flow margin 58.52% (16.07%) 0.00%
Return on equity 20.12% (53.31%) (56.36%)
Return on assets 18.30% (28.77%) (48.04%)
Return on invested capital 24.07% (787.33%) 0.00%

Growth

Metric KRYS MDGL Biotechnology median
Revenue growth (TTM) 22.63% 149.04% 6.02%
EPS growth (last fiscal year) 128.00% 41.32% 30.26%
Revenue growth, 5-year CAGR — — 9.41%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric KRYS MDGL Biotechnology median
Debt to equity 0.00 0.65 0.00
Current ratio 8.32 3.20 4.72
Net debt to EBITDA (4.93) 2.21 0.96

Dividend

Metric KRYS MDGL Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric KRYS MDGL Biotechnology median
Market cap 9.77b 10.62b 135.18m

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