Madrigal Pharmaceuticals, Inc.

MDGL Healthcare Biotechnology

Madrigal Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $958.4 million, up 432.1% from fiscal 2024.

Revenue
+50.1%
EPS
+147.3%
Free cash flow
+53.5%
Total debt
+0.45%

Quarter to September 2026, against a year earlier

390.52 9.58 −2.39%
Market cap
$9.3B
P/E
0.0×
Fwd P/E
−68.8×
Dividend yield
—
F-score
n/a
Altman Z
10.48
Beneish M
0.50
Dividend safety
n/a

Madrigal Pharmaceuticals, Inc. (MDGL) Operating margin

Alert me on Operating margin

Madrigal Pharmaceuticals, Inc.'s operating margin over the twelve months to 30 September 2026 was −10.7%, up 20.6 percentage points from fiscal 2025 (−31.3%). Over the past ten years it has ranged from −276.4% (fiscal 2024) to 0.00% (fiscal 2023); the current reading is higher than 18% of that period. That is below the Biotechnology industry median of 0.00% and below the Healthcare sector median of 0.00%.

Operating margin, annual

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Annual newest first

Period Operating margin Change (points)
FY2025 −31.3% 245.08
FY2024 −276.4% (276.39)
FY2023 0.00% 0.00
FY2022 0.00% 0.00
FY2021 0.00% 0.00
FY2020 0.00% 0.00
FY2019 0.00% 0.00
FY2018 0.00% 0.00
FY2017 0.00% 0.00
FY2016 0.00% 0.00

Quarterly newest first

Period Operating margin Change (points)
Sep 2026 13.0% 28.44
Jun 2026 −15.5% 14.32
Mar 2026 −29.8% (11.22)
Dec 2025 −18.6% 21.12
43 more quarters

Against its own ten years

Low −276.4% High 0.00%
Ten-year median 0.00%
Current reading's percentile 18

Operating margin against peers

Company Operating margin
KRYS Krystal Biotech, Inc. compare 48.4%
PTGX Protagonist Therapeutics, Inc. compare 20.7%
TGTX TG Therapeutics, Inc. compare 17.1%
CAI Caris Life Sciences,�Inc. compare 13.4%
SYRE Spyre Therapeutics, Inc. compare 0.00%
MDGL Madrigal Pharmaceuticals, Inc. −10.7%
TWST Twist Bioscience Corporation compare −33.6%
IBRX ImmunityBio, Inc. compare −151.9%
CYTK Cytokinetics, Incorporated compare −625.2%
Biotechnology industry median 0.00%
Healthcare sector median 0.00%
Market median 0.00%

What Operating margin is

EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.

EBIT ÷ Revenue

The full definition of Operating margin →

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