Krystal Biotech, Inc. KRYS

345.82 0.86 0.25% as of 25 Sep
Market cap
$10.2B
P/E
41.9×
Growth Flags show if company had growth for consecutive years

Insider Decisions

Total sells 105.27
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — —
Sell — — 2 — 4 3 — 1 3 — 1 2
Insider Ownership 12.05%

Capital & Financial Ratios

Market Cap 10,210.00
Revenue 440.48
Net Income 241.46
Free Cash Flow 257.78
Net Debt (845.63)
Current Ratio 8.32
Debt/Equity 0.00
P/E ratio 41.86
P/S ratio 23.21
P/B ratio 7.52
Past 5Y EPS Growth (29.98%)
This Y EPS Growth 11.22%
Next Y EPS Growth 22.94%
Next 5Y EPS Growth 29.04%
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 532 598 828 846
Receivables 42 105 127 139
Inventory 7 27 40 46
Other — — — —
588 742 1,025 1,060
2023 2024 2025 Q'26
Payables 4 5 3 7
ST’ Debt — — — —
Other — — — —
33 102 103 127
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — —
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 33.09% 32.67%

Revenue

Mar Jun Sep Dec Year
’26 116 119 — — —
’25 88 96 98 107 389
’24 45 70 84 91 291
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 80 75 — — —
’25 31 53 40 78 201
’24 16 (4) 59 53 123
’23 (26) (34) (21) (7) (89)
’22 (15) (43) (20) (22) (101)
’21 (10) (10) (7) (21) (48)
’20 (6) (5) (7) (8) (26)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 73 71 — — —
’25 25 51 38 75 189
’24 15 (5) 58 52 119
’23 (32) (37) 77 (9) (1)
’22 (33) (60) (34) (28) (154)
’21 (12) (14) (28) (62) (116)
’20 (8) (7) (11) (15) (41)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 1.83 1.79 — — —
’25 1.20 1.29 2.66 1.70 6.84
’24 0.03 0.53 0.91 1.52 3.00
’23 (1.76) (1.25) 2.79 0.30 0.39
’22 (1.99) (1.10) (1.17) (1.25) (5.49)
’21 (0.74) (0.74) (0.70) (0.94) (3.13)
’20 (0.31) (0.37) (0.49) (0.53) (1.71)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.2
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— 8.03 8.61 18.50 33.09 38.86 47.67 69.81 107.50 122.80

Analyst estimates 2026–2028

Powerpack
Low Price
— 11.98 28.75 66.50 66.85 102.99 85.11 132.68 219.34 265.92
High Price
7 12 37 53 75 119 210 229 275 295
Employees
0 0 0 0 0 0 0 0 1 1
Revenue/Emp
— — — — — — — 51 291 389
Revenue
0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 93.90% 93.09% 94.08%
Gross Margin
(1) (8) (11) (19) (32) (70) (140) 13 95 189
EBT
0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 25.44% 32.82% 48.69%
EBT Margin
(1) (8) (11) (19) (32) (70) (140) 11 89 205
Net Income
0 0 0 1 2 3 3 6 7 7
Depreciation
0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.87 10.16 13.44
Revenue/Sh
(1.31) (1.48) (0.97) (1.20) (1.71) (3.13) (5.49) 0.40 3.12 7.08
Earnings/Sh
(1.49) (0.73) (0.84) (1.18) (1.39) (2.16) (3.95) (3.27) 4.32 6.94
Cash Flow/Sh
(0.02) (0.04) (0.20) (0.40) (0.79) (3.08) (2.08) 3.25 (0.15) (0.40)
Capex/Sh
(1.51) (0.76) (1.04) (1.58) (2.18) (5.24) (6.02) (0.02) 4.17 6.54
Free CF/Sh
0.33 9.23 10.11 12.76 15.55 26.74 20.49 28.68 33.10 42.14
Book Value/Sh
1 5 11 16 19 22 25 27 29 29
Shares
— — — — — — — 694.22 50.54 34.82
PE Ratio
— — — — — — — 0.00 15.42 18.34
PS Ratio
— — — — — — — 4.36 4.73 5.85
PB Ratio
— — — — — — — 0.00 13.36 16.21
EV/Sales
— — — — — — — (4,744.59) 32.57 33.31
EV/FCF
(1) (4) (9) (19) (26) (48) (101) (89) 123 201
Op' Cash Flow
0 0 (2) (6) (15) (68) (53) 88 (4) (12)
Capex
(1) (4) (12) (25) (41) (116) (154) (1) 119 189
FCF
2 49 110 193 260 417 355 555 640 922
Working Cap'
2 — — 3 3 7 7 — — —
Total Debt
0 (50) (112) (191) (268) (431) (372) (532) (598) (828)
Net Debt
0 49 113 203 292 594 522 779 946 1,220
Sh' Equity
(4.40%) (30.29%) (13.10%) (11.74%) (12.38%) (14.85%) (23.63%) 1.59% 9.51% 17.14%
ROA
(341.81%) 0.00% (508.36%) (114.90%) (85.47%) (26.27%) (60.32%) (27.80%) 11.78% 25.73%
ROIC
(4.76%) (32.76%) (13.39%) (12.08%) (13.00%) (15.71%) (25.09%) 1.68% 10.34% 18.91%
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Krystal Biotech, Inc. (KRYS) key facts

  • Krystal Biotech, Inc. (KRYS) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • Krystal Biotech, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $389.1 million, up 33.9% from fiscal 2024.
  • Net income was $204.8 million, or $7.08 per share (basic), a net margin of 52.6%.
  • As of September 25, 2026, KRYS traded at $345.82, a market capitalization of $10.2 billion.
  • At that price the stock trades at 41.9× trailing-twelve-month earnings and 23.2× sales.
  • Return on equity was 18.9% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Krystal Biotech, Inc. (KRYS) Latest News

News by impact score

Fine-tune

3 Sep

3

Krystal Biotech stock rose 13.4% over the past month on factors behind the rally. Monthly stock gain signals moderately positive momentum without altering long-term trajectory.

14 Aug

4

RBC analysts position Krystal Biotech for further stock gains on Vyjuvek performance and upcoming pipeline readouts. RBC positive stance on Vyjuvek and pipeline data directly supports significant upside in KRYS valuation and investor interest.

10 Aug

4 transcript

Krystal Biotech (KRYS) released its Q2 2026 earnings call transcript covering financial results and operations. Q2 earnings details directly affect valuation, guidance and investor sentiment for Krystal Biotech.

4 Aug

4

J&J pharma leader retires. Krystal Biotech shares slump after gene therapy miss. Gene therapy miss triggers share slump and signals major setback to core development pipeline.

3

Krystal Biotech beat Q2 earnings and sales estimates. Pipeline developments now take center stage for the company. Q2 beat offers moderate short-term positive signal but pipeline focus limits fundamental trajectory change.

3 transcript

Krystal Biotech, Inc. held its Q2 2026 earnings call covering quarterly financial results, operational progress, and forward guidance. Quarterly earnings calls deliver financial updates and guidance that can sway market perception of the company's prospects.

3 Aug

4 transcript

Krystal Biotech's VYJUVEK sales rose 24% per Q2 2026 earnings call highlights. 24% VYJUVEK sales growth signals major revenue gains and stronger market position.

3

Krystal Biotech Q2 earnings call highlighted financial results, operational progress and company outlook. Quarterly earnings provide updates on financials and strategy with moderate effect on near-term sentiment.

3

Krystal Biotech reported Q2 earnings and revenues exceeding estimates. Q2 earnings beat signals positive financial performance without fundamentally shifting company trajectory.

3

Krystal Biotech reported second quarter 2026 financial results and operating updates. Quarterly financial results provide performance data that can moderately shift investor views and near-term valuation.

29 Jul

3

Krystal Biotech shares rose 7.9% after S&P MidCap 400 index inclusion and KB801 patent filing update. S&P 400 addition and patent update deliver moderate visibility and IP gains without altering core operations or long-term trajectory.

27 Jul

3

Krystal Biotech earnings are projected to grow, raising questions over potential stock purchases. Projected earnings growth may moderately affect KRYS valuation and investor interest without guaranteeing major trajectory shifts.

4 Jun

4

Krystal Biotech shares rose 16% over three months on positive gene therapy trial data and pipeline progress. Clinical successes and pipeline momentum are driving sustained stock gains and improved long-term outlook.

18 May

4

Krystal Biotech received MHRA approval in the United Kingdom for VYJUVEK to treat dystrophic epidermolysis bullosa. UK regulatory approval for VYJUVEK directly expands addressable market and revenue outlook for Krystal Biotech's lead product.

11 May

4

Krystal Biotech (KRYS) shares surged 6.5% after Q1 profit jumped due to Vyjuvek sales and positive investor conference updates. Vyjuvek-fueled Q1 profit increase and investor updates triggered 6.5% stock rise, boosting financial outlook and sentiment.

3

Krystal Biotech, Inc. (KRYS), a profitable biotech, stealthily climbs into a buy zone, signaling strong market potential. KRYS's profitable operations and entry into buy zone provide moderately noticeable positive influence on stock performance and investor sentiment.

5 May

4

Krystal Biotech (KRYS) Q1 earnings and sales beat estimates, with pipeline developments in focus. Q1 earnings and sales beats highlight strong financial performance and pipeline potential, significantly impacting future trajectory and investor sentiment.

4 May

4

Krystal Biotech, Inc. (KRYS) released Q1 2026 earnings call summary highlighting financial results, operational updates, and forward guidance. Q1 2026 earnings summary details financial performance and strategic updates with potential to significantly shape KRYS market trajectory and investor sentiment.

4 transcript

Krystal Biotech (KRYS) released Q1 2025 earnings call transcript detailing financial results, pipeline progress, and forward guidance. Q1 2025 earnings transcript covers financials, clinical updates, and strategic outlook with potential to drive stock volatility and long-term valuation.

4

Krystal Biotech Q1 earnings call highlights financial results, pipeline updates including Vyjuvek sales growth, clinical trial progress, and reaffirmed full-year guidance. Q1 earnings highlights detail strong revenue growth, positive clinical data, and strategic expansions significantly boosting KRYS market position and investor outlook.

4

Krystal Biotech, Inc. (KRYS) beat Q1 earnings and revenue estimates. Beating Q1 earnings and revenue estimates boosts investor sentiment and signals strong financial performance for future growth.

4

Krystal Biotech, Inc. (KRYS) announced first quarter 2026 financial and operating results. Quarterly financial and operating results announcements often drive significant stock volatility and shape investor expectations for biotech firms.

2 May

4

Krystal Biotech (KRYS) narrative shifts positively with Vyjuvek's momentum and advancing late-stage pipeline, positioning the company for growth amid biotech sector dynamics. Vyjuvek's progress and late-stage pipeline signal major strategic advancements likely to alter KRYS trajectory and investor sentiment.

27 Apr

4

Krystal Biotech (KRYS) earnings are expected to grow ahead of next week's release, with analysts highlighting key factors like revenue projections and comparisons to prior results. Expected earnings growth represents a major financial milestone that could significantly alter investor sentiment and stock trajectory.

16 Apr

3

Vertex Pharmaceuticals faces potential empire-shaking challenges in gene therapy, opening opportunities for Krystal Biotech's competitive edge with Vyjuvek. Vertex's troubles moderately enhance KRYS's positioning in gene therapy amid shifting market dynamics.

7 Apr

3

Krystal Biotech (KRYS), an under-the-radar healthcare stock, holds potential to set investors up for life amid strong growth prospects in biotech. Promotion of KRYS as life-changing investment moderately boosts market sentiment and stock trajectory without fundamental shifts.

20 Mar

4

Krystal Biotech stock outlook balances high cash burn against promising late-stage clinical data. Late-stage data offers significant potential to drive approvals and partnerships, offsetting cash burn risks.

19 Mar

3

Krystal Biotech (KRYS) shares have fallen 11.5% since the last earnings report amid investor reactions to the results. Post-earnings 11.5% stock drop signals moderate concerns over financial performance and market sentiment.

17 Mar

5

Krystal Biotech's YJUVEK label updated with expanded indications and KB803 demonstrates significant clinical progress, positioning both as potential game changers for the company's growth and market position. YJUVEK label update expands market access while KB803 progress advances a high-potential pipeline asset, fundamentally enhancing KRYS's long-term prospects.

16 Mar

4

Krystal Biotech, Inc. (KRYS) secures $8 million investment for its breakout multiple sclerosis drug despite a 30% stock drop. $8 million investment in breakout MS drug counters 30% stock drop, signaling major boost to strategic positioning and investor sentiment.

stockrow.com/KRYS · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com