Krystal Biotech, Inc.

KRYS Healthcare Biotechnology

Krystal Biotech, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $389.1 million, up 33.9% from fiscal 2024. In the quarter to June 2026, revenue grew 24.1%, EPS grew 39.1% and free cash flow grew 40.1%, each against the same quarter a year earlier. Operating cash flow growth for three consecutive years.

316.58 13.42 −4.07%
Market cap
$9.8B
P/E
38.3×
Fwd P/E
38.6×
Dividend yield
—
F-score
7/9
Altman Z
39.03
Beneish M
−2.27
Dividend safety
n/a

Insider Decisions trades per month

Total sells 105.27
Totals in millions of $.
Dec 25 Mar 26 Jun 26 Sep 26
Buy — — — — — — — — — — — —
Sell — 2 — 4 3 — 1 3 — 1 2 —
Insider Ownership 12.05%

Capital & Financial Ratios $m

Market Cap 9,770.00
Revenue 440.48
Net Income 241.46
Free Cash Flow 257.78
Net Debt (845.63)
Current Ratio 8.32 (at or above 1.5: strong)
Debt/Equity 0.00 (at or below 0.5: strong)
P/E ratio 38.28 (above 35: high)
Fwd P/E 38.60 (above 35: high)
P/S ratio 21.22 (above 10: high)
P/B ratio 6.88 (above 6: high)
Past 5Y EPS Growth —
This Y EPS Growth 8.20%
Next Y EPS Growth 23.03% (at or above 15%: strong)
Next Y revenue growth 28.03% (at or above 10%: strong)
Next 5Y EPS Growth 24.30% (at or above 15%: strong)

Green and red mark values outside typical ranges. How we judge →

Valuation vs history

P/B against its own 10 years 94.68%
10-year low 10-year high

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2021 Powerpack
2020 Powerpack
2019 Powerpack
2017 Powerpack
predictions special payouts not included in total or ratios

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 532 598 828 846
Receivables 42 105 127 139
Inventory 7 27 40 46
Other — — — —
588 742 1,025 1,060
2023 2024 2025 Q'26
Payables 4 5 3 7
ST’ Debt — — — —
Other — — — —
33 102 103 127

Compound Annual Growth %

10y 5y 3y
Sales — — —
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 33.09% 32.67%

Revenue $m

Mar Jun Sep Dec Year
’26 116 119 — — —
’25 88 96 98 107 389
’24 45 70 84 91 291
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 80 75 — — —
’25 31 53 40 78 201
’24 16 (4) 59 53 123
’23 (26) (34) (21) (7) (89)
’22 (15) (43) (20) (22) (101)
’21 (10) (10) (7) (21) (48)
’20 (6) (5) (7) (8) (26)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 73 71 — — —
’25 25 51 38 75 189
’24 15 (5) 58 52 119
’23 (32) (37) 77 (9) (1)
’22 (33) (60) (34) (28) (154)
’21 (12) (14) (28) (62) (116)
’20 (8) (7) (11) (15) (41)
Fiscal quarters ending in the months shown.

EPS $

Mar Jun Sep Dec Year
’26 1.83 1.79 — — —
’25 1.20 1.29 2.66 1.70 6.84
’24 0.03 0.53 0.91 1.52 3.00
’23 (1.76) (1.25) 2.79 0.30 0.39
’22 (1.99) (1.10) (1.17) (1.25) (5.49)
’21 (0.74) (0.74) (0.70) (0.94) (3.13)
’20 (0.31) (0.37) (0.49) (0.53) (1.71)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

1.2
1Buy 2 3Hold 4 5Sell

Ten years at a glance Fiscal years to December

Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Trend 2026e 2027e 2028e
Price, $
Price, $ Low — 8.03 8.61 18.50 33.09 38.86 47.67 69.81 107.50 122.80

Analyst estimates 2026–2028

Powerpack
High — 11.98 28.75 66.50 66.85 102.99 85.11 132.68 219.34 265.92
People
People Employees 7 12 37 53 75 119 210 229 275 295
Revenue/emp, $m 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.22 1.06 1.32
Income, $m
Income, $m Revenue — — — — — — — 51 291 389
Gross margin, % 0.00 0.00 0.00 0.00 0.00 0.00 0.00 93.90 93.09 94.08
EBT (1) (8) (11) (19) (32) (70) (140) 13 95 189
EBT margin, % 0.00 0.00 0.00 0.00 0.00 0.00 0.00 25.44 32.82 48.69
Net income (1) (8) (11) (19) (32) (70) (140) 11 89 205
Depreciation 0 0 0 1 2 3 3 6 7 7
Per share, $
Per share, $ Revenue 0.00 0.00 0.00 0.00 0.00 0.00 0.00 1.87 10.16 13.44
Earnings (1.31) (1.48) (0.97) (1.20) (1.71) (3.13) (5.49) 0.40 3.12 7.08
Cash flow (1.49) (0.73) (0.84) (1.18) (1.39) (2.16) (3.95) (3.27) 4.32 6.94
Capex (0.02) (0.04) (0.20) (0.40) (0.79) (3.08) (2.08) 3.25 (0.15) (0.40)
Free cash flow (1.51) (0.76) (1.04) (1.58) (2.18) (5.24) (6.02) (0.02) 4.17 6.54
Book value 0.33 9.23 10.11 12.76 15.55 26.74 20.49 28.68 33.10 42.14
Shares, m 1 5 11 16 19 22 25 27 29 29
Valuation, ×
Valuation, × P/E — — — — — — — 694.22 50.54 34.82
P/S — — — — — — — 0.00 15.42 18.34
P/B — — — — — — — 4.36 4.73 5.85
EV/Sales — — — — — — — 0.00 13.36 16.21
EV/FCF — — — — — — — (4,744.59) 32.57 33.31
Cash, $m
Cash, $m Operating cash flow (1) (4) (9) (19) (26) (48) (101) (89) 123 201
Capex 0 0 (2) (6) (15) (68) (53) 88 (4) (12)
Free cash flow (1) (4) (12) (25) (41) (116) (154) (1) 119 189
Balance, $m
Balance, $m Working capital 2 49 110 193 260 417 355 555 640 922
Total debt 2 — — 3 3 7 7 — — —
Net debt 0 (50) (112) (194) (271) (438) (379) (532) (598) (828)
Shareholders’ equity 0 49 113 203 292 594 522 779 946 1,220
Returns, %
Returns, % ROA (4.40) (30.29) (13.10) (11.74) (12.38) (14.85) (23.63) 1.59 9.51 17.14
ROIC (341.81) 0.00 (508.36) (149.54) (99.05) (27.45) (63.43) (27.80) 11.78 25.73
ROE (4.76) (32.76) (13.39) (12.08) (13.00) (15.71) (25.09) 1.68 10.34 18.91
Negative figures in brackets.

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Charts ten years each

Krystal Biotech, Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
BMRN BioMarin Pharmaceutical Inc. $10.9B 144× 16.1× +19.91% (above 0%: growing) −81.60% (below 0%: shrinking) −20.28% (below 0%: shrinking) 79.51% 11.21% Compare
MDGL Madrigal Pharmaceuticals, Inc. $10.6B — (loss-making) — (loss-making) +71.17% (above 0%: growing) n/m +140.54% (above 0%: growing) 89.02% (15.46%) Compare
IBRX ImmunityBio, Inc. $10.6B — (loss-making) — (loss-making) +93.91% (above 0%: growing) n/m +13.38% (above 0%: growing) 99.42% (120.41%) Compare
PCVX Vaxcyte, Inc. $10.3B — (loss-making) — — n/m −92.55% (below 0%: shrinking) 0.00% 0.00% Compare
KRYS Krystal Biotech, Inc. $9.8B 38.3× 38.6× +24.14% (above 0%: growing) +39.10% (above 0%: growing) +40.14% (above 0%: growing) 94.60% 49.00%
KYMR Kymera Therapeutics, Inc. $9.0B — (loss-making) — (loss-making) +466.40% (above 0%: growing) n/m +9.97% (above 0%: growing) 100.00% (116.32%) Compare
CAI Caris Life Sciences,�Inc. $9.0B 81.3× 163× +45.38% (above 0%: growing) n/m +8.47% (above 0%: growing) 68.10% 10.21% Compare
CYTK Cytokinetics, Incorporated $8.9B — (loss-making) — (loss-making) −57.13% (below 0%: shrinking) n/m −24.02% (below 0%: shrinking) 80.46% (625.95%) Compare
PTGX Protagonist Therapeutics, Inc. $8.8B 106× 25.0× +3,749.17% (above 0%: growing) n/m +839.65% (above 0%: growing) 100.00% 74.37% Compare
Median of peers $9.6B 106× 25.0× +71.17% — +9.22% 84.74% (7.73%)

All 614 Biotechnology stocks →

Krystal Biotech, Inc. (KRYS) key facts

  • Strength: Krystal Biotech, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $389.1 million, up 33.9% from fiscal 2024.
  • Strength: Net income was $204.8 million, or $7.08 per share (basic), a net margin of 52.6%.
  • Krystal Biotech, Inc. (KRYS) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • As of October 16, 2026, KRYS traded at $316.58, a market capitalization of $9.8 billion.
  • At that price the stock trades at 38.3× trailing-twelve-month earnings and 21.2× sales.
  • Return on equity was 18.9% and debt-to-equity 0.00.
  • Its Piotroski F-score is 7 out of 9 and its Altman Z-score is 39.03 (safe zone) for fiscal 2025.

Source: company filings (standardised) and stockrow calculations.

Krystal Biotech, Inc. (KRYS) Latest News

stockrow.com/KRYS · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com