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Spyre Therapeutics, Inc. (SYRE) vs TG Therapeutics, Inc. (TGTX)

Spyre Therapeutics, Inc. and TG Therapeutics, Inc. are both Biotechnology companies. TG Therapeutics, Inc. is the larger, with a market value of $8.6B against $7.4B — 1.2× the size. Spyre Therapeutics, Inc. has negative trailing earnings, so its P/E is not meaningful; TG Therapeutics, Inc. trades at 17.8×. TG Therapeutics, Inc. grew revenue faster over the last twelve months: 76.1% against −81.8%. TG Therapeutics, Inc. has the higher net margin (55.2% vs 0.00%) and the higher return on invested capital (10.7% vs 0.00%). Across the 18 metrics below, TG Therapeutics, Inc. leads on 14 and Spyre Therapeutics, Inc. on 4.

Valuation

Metric SYRE TGTX Biotechnology median
P/E n/m 17.75 8.50
P/S 6,423.00 9.57 9.71
P/B 7.09 12.67 2.13
Price to free cash flow n/m 440.11 20.82
EV/EBITDA n/m 57.69 0.64
EV/Sales 5,336.34 9.81 9.21
Earnings yield (2.67%) 5.63% (33.15%)
Free cash flow yield (3.08%) 0.23% (25.50%)

Profitability

Metric SYRE TGTX Biotechnology median
Gross margin 100.00% 82.37% 65.16%
Operating margin 0.00% 17.05% 0.00%
Net margin 0.00% 55.22% 0.00%
Free cash flow margin 0.00% 2.17% 0.00%
Return on equity (28.52%) 100.28% (56.36%)
Return on assets (20.90%) 37.70% (48.04%)
Return on invested capital 0.00% 10.69% 0.00%

Growth

Metric SYRE TGTX Biotechnology median
Revenue growth (TTM) (81.84%) 76.08% 6.02%
EPS growth (last fiscal year) 55.24% 1,746.67% 30.26%
Revenue growth, 5-year CAGR (28.15%) 426.73% 9.41%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric SYRE TGTX Biotechnology median
Debt to equity 0.00 1.23 0.00
Current ratio 18.53 4.27 4.72
Net debt to EBITDA 3.61 0.86 0.96

Dividend

Metric SYRE TGTX Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric SYRE TGTX Biotechnology median
Market cap 7.39b 8.57b 135.18m

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