stockrowSpyre Therapeutics, Inc.
SYRE Healthcare Biotechnology
Spyre Therapeutics, Inc.’s revenue for fiscal 2023 (year ended December 2023) was $886,000.00, down 62.0% from fiscal 2022.
- EPS
- −624.8%
- Free cash flow
- −108.8%
Quarter to September 2026, against a year earlier
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Spyre Therapeutics, Inc. (SYRE) Net margin
Spyre Therapeutics, Inc.'s net margin over the twelve months to 30 September 2026 was 0.00%, down 0.0 percentage points from fiscal 2025 (0.00%). Over the past ten years it has ranged from −10,709.1% (fiscal 2023) to 0.00% (fiscal 2025) — the current reading is the highest in ten years. That is in line with the Biotechnology industry median of 0.00% and in line with the Healthcare sector median of 0.00%.
Net margin, annual
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Annual newest first
| Period | Net margin | Change (points) |
|---|---|---|
| FY2025 | 0.00% | 0.00 |
| FY2024 | 0.00% | 10,709.14 |
| FY2023 | −10,709.1% | (7,110.39) |
| FY2022 | −3,598.8% | (3,247.61) |
| FY2021 | −351.1% | (351.14) |
| FY2020 | 0.00% | 0.00 |
| FY2019 | 0.00% | 1,140.64 |
| FY2018 | −1,140.6% | (617.37) |
| FY2017 | −523.3% | (54.43) |
| FY2016 | −468.8% | (279.47) |
Quarterly newest first
| Period | Net margin | Change (points) |
|---|---|---|
| Sep 2026 | 0.00% | 0.00 |
| Jun 2026 | 0.00% | 0.00 |
| Mar 2026 | 0.00% | 0.00 |
| Dec 2025 | 0.00% | 0.00 |
| 43 more quarters | Free account |
Against its own ten years
Net margin against peers
| Company | Net margin |
|---|---|
| TGTX TG Therapeutics, Inc. compare | 55.2% |
| KRYS Krystal Biotech, Inc. compare | 47.9% |
| PTGX Protagonist Therapeutics, Inc. compare | 29.4% |
| CAI Caris Life Sciences,�Inc. compare | 9.16% |
| SYRE Spyre Therapeutics, Inc. | 0.00% |
| MDGL Madrigal Pharmaceuticals, Inc. compare | −10.9% |
| TWST Twist Bioscience Corporation compare | −31.7% |
| IBRX ImmunityBio, Inc. compare | −598.6% |
| CYTK Cytokinetics, Incorporated compare | −686.6% |
| Biotechnology industry median | 0.00% |
| Healthcare sector median | 0.00% |
| Market median | 1.06% |
What Net margin is
Net Profit Margin tells an investor how much of each unit of revenue ends up as profit for shareholders after all costs, interest and taxes.
Net Income Allotted to Shareholders ÷ Revenue
More on SYRE
- Revenue
- Net income
- EPS (diluted)
- EBITDA
- Free cash flow
- Operating cash flow
- Gross margin
- Operating margin
- Free cash flow margin
- P/E ratio
- P/S ratio
- P/B ratio
- Price to free cash flow
- EV/EBITDA
- EV/Sales
- EV/FCF
- Return on equity
- Return on assets
- Return on invested capital
- Debt to equity
- Current ratio
- Total debt
- Shares outstanding
- Book value per share
- Revenue growth
- Piotroski F-score
- Altman Z-score
- The full statement