Spyre Therapeutics, Inc.

SYRE Healthcare Biotechnology

Spyre Therapeutics, Inc.’s revenue for fiscal 2023 (year ended December 2023) was $886,000.00, down 62.0% from fiscal 2022.

EPS
−624.8%
Free cash flow
−108.8%

Quarter to September 2026, against a year earlier

102.24 5.65 +5.85%
Market cap
$9.2B
P/E
0.0×
Fwd P/E
−4.8×
Dividend yield
—
F-score
3/9
Altman Z
−3.82
Beneish M
n/a
Dividend safety
n/a

Spyre Therapeutics, Inc. (SYRE) EPS (diluted)

Alert me on EPS (diluted)

Spyre Therapeutics, Inc.'s EPS (diluted) for fiscal 2025 was −$1.98, compared with −$4.42 in fiscal 2024. Over the twelve months to 30 September 2026 it was −$3.07. Over the past ten years it has ranged from −$470.79 (fiscal 2015) to −$1.98 (fiscal 2025) — the current reading is the highest in ten years. EPS (diluted) has risen for 6 consecutive fiscal years. Spyre Therapeutics, Inc. ranks 378th of 580 Biotechnology companies by EPS (diluted).

EPS (diluted), annual

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Annual newest first

Period EPS (diluted) Change
FY2025 −$1.98 —
FY2024 −$4.42 —
FY2023 −$13.76 —
FY2022 −$24.75 —
FY2021 −$25.00 —
FY2020 −$38.00 —
FY2019 −$61.25 —
FY2018 −$53.25 —
FY2017 −$45.00 —
FY2016 −$55.50 —

Quarterly newest first

Period EPS (diluted) Change
Sep 2026 −$1.09 —
Jun 2026 −$0.36 —
Mar 2026 −$0.74 —
Dec 2025 −$0.89 —
43 more quarters

Against its own ten years

Low −$470.79 High −$1.98
Ten-year median −$38.00
Current reading's percentile 100

EPS (diluted) against peers

What EPS (diluted) is

Diluted EPS tells an investor how much profit a company earned for each share, counting the extra shares that options and convertible securities could create.

Reported line item

The full definition of EPS (diluted) →

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