Friday 6 November 2026 Export SYRE’s income statement to Excel — free account

Spyre Therapeutics, Inc.

Spyre Therapeutics, Inc.’s revenue for fiscal 2023 (year ended December 2023) was $886,000.00, down 62.0% from fiscal 2022.

EPS: −624.8%
Free cash flow: −108.8%

Quarter to September 2026, against a year earlier

102.84 6.25 +6.47%

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Market cap: $9.2B
P/E: 0.0×
Fwd P/E: −4.8×
Dividend yield: —
F-score: 3/9
Altman Z: −3.82
Beneish M: n/a
Dividend safety: n/a

Overview Business Profile Earnings & Analysis Segments Valuation Filings

Spyre Therapeutics, Inc. (SYRE) P/E ratio

Alert me on P/E ratio

Spyre Therapeutics, Inc. has no meaningful P/E ratio: its trailing twelve-month earnings is negative. Over the past ten years it has ranged from 0.0× (November 2026) to 0.0× (November 2026) — the current reading is the highest in ten years.

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<iframe src="https://stockrow.com/embed/SYRE/pe-ratio" width="100%" height="360" style="border:0" loading="lazy" title="Spyre Therapeutics, Inc. P/E ratio, 10 years"></iframe>
<p style="font-size:12px">Source: <a href="https://stockrow.com/SYRE/metrics/pe-ratio">Spyre Therapeutics, Inc. (SYRE) P/E ratio — stockrow.com</a></p>

Period	P/E ratio	Change
FY2023	0.0×	—
FY2022	0.0×	—
FY2021	0.0×	—
FY2018	0.0×	—
FY2017	0.0×	—
FY2016	0.0×	—
FY2015	0.0×	—

Period	P/E ratio	Change
Dec 2023	0.0×	—
Jun 2023	0.0×	—
Mar 2023	0.0×	—
Dec 2022	0.0×	—
19 more quarters	Free account

Against its own ten years

Low 0.0× High 0.0×

Ten-year median 0.0×

Current reading's percentile 100

Company	P/E ratio
TWST Twist Bioscience Corporation compare	n/m
SYRE Spyre Therapeutics, Inc.	n/m
CYTK Cytokinetics, Incorporated compare	n/m
IBRX ImmunityBio, Inc. compare	n/m
MDGL Madrigal Pharmaceuticals, Inc. compare	n/m
TGTX TG Therapeutics, Inc. compare	19.1×
KRYS Krystal Biotech, Inc. compare	39.2×
CAI Caris Life Sciences,�Inc. compare	77.7×
PTGX Protagonist Therapeutics, Inc. compare	111×
Biotechnology industry median	10.3×
Healthcare sector median	25.2×
Market median	17.9×

What P/E ratio is

Price to Earnings Ratio shows how much investors pay for each dollar of a company’s annual profit per share.

Stock Price ÷ EPS (Basic) (TTM)

The full definition of P/E ratio →

Spyre Therapeutics, Inc. (SYRE) P/E ratio

P/E ratio, daily

Annual newest first

Quarterly newest first

Against its own ten years

P/E ratio against peers

What P/E ratio is

More on SYRE

P/E ratio, daily

Annual newest first

Quarterly newest first

Against its own ten years

P/E ratio against peers

What P/E ratio is

More on SYRE

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