Spyre Therapeutics, Inc.

SYRE Healthcare Biotechnology

Spyre Therapeutics, Inc.’s revenue for fiscal 2023 (year ended December 2023) was $886,000.00, down 62.0% from fiscal 2022.

EPS
−624.8%
Free cash flow
−108.8%

Quarter to September 2026, against a year earlier

102.07 5.48 +5.67%
Market cap
$9.2B
P/E
0.0×
Fwd P/E
−4.8×
Dividend yield
—
F-score
3/9
Altman Z
−3.82
Beneish M
n/a
Dividend safety
n/a

Spyre Therapeutics, Inc. (SYRE) Return on assets

Alert me on Return on assets

Spyre Therapeutics, Inc.'s return on assets over the twelve months to 30 September 2026 was −30.9%, down 12.6 percentage points from fiscal 2025 (−18.3%). Over the past ten years it has ranged from −97.3% (fiscal 2019) to −18.3% (fiscal 2025) — the current reading is the highest in ten years. That is above the Biotechnology industry median of −45.6% and below the Healthcare sector median of −29.3%.

Return on assets, annual

Embed this chart

Annual newest first

Period Return on assets Change (points)
FY2025 −18.3% 25.52
FY2024 −43.8% 2.17
FY2023 −46.0% 46.63
FY2022 −92.6% (44.12)
FY2021 −48.5% 17.63
FY2020 −66.1% 31.17
FY2019 −97.3% (30.98)
FY2018 −66.3% (22.04)
FY2017 −44.2% (3.19)
FY2016 −41.1% 14.37

Against its own ten years

Low −97.3% High −18.3%
Ten-year median −48.5%
Current reading's percentile 100

Return on assets against peers

Company Return on assets
TGTX TG Therapeutics, Inc. compare 37.7%
KRYS Krystal Biotech, Inc. compare 15.9%
PTGX Protagonist Therapeutics, Inc. compare 10.3%
CAI Caris Life Sciences,�Inc. compare 8.58%
MDGL Madrigal Pharmaceuticals, Inc. compare −11.1%
TWST Twist Bioscience Corporation compare −20.8%
SYRE Spyre Therapeutics, Inc. −30.9%
CYTK Cytokinetics, Incorporated compare −47.7%
IBRX ImmunityBio, Inc. compare −192.6%
Biotechnology industry median −45.6%
Healthcare sector median −29.3%
Market median 0.00%

What Return on assets is

ROA tells an investor how much profit a company earns for shareholders from the assets it uses to run its business.

Annual: Net Income Allotted to Shareholders ÷ Average Assets; TTM: Net Income Allotted to Shareholders ÷ Average Assets (latest quarter)

The full definition of Return on assets →

More on SYRE