Cytokinetics, Incorporated (CYTK) vs Protagonist Therapeutics, Inc. (PTGX)

Cytokinetics, Incorporated and Protagonist Therapeutics, Inc. are both Biotechnology companies. Cytokinetics, Incorporated and Protagonist Therapeutics, Inc. are of similar size ($9.0B and $8.9B). Cytokinetics, Incorporated has negative trailing earnings, so its P/E is not meaningful; Protagonist Therapeutics, Inc. trades at 117×. Protagonist Therapeutics, Inc. grew revenue faster over the last twelve months: 34.8% against −21.1%. Protagonist Therapeutics, Inc. has the higher net margin (29.4% vs −1,321.1%) and the higher return on invested capital (61.8% vs 0.00%). Across the 17 metrics below, Protagonist Therapeutics, Inc. leads on 13 and Cytokinetics, Incorporated on 4.

Valuation

Metric CYTK PTGX Biotechnology median
P/E n/m 116.99 7.88
P/S 126.21 33.37 11.47
P/B n/m 11.18 2.52
Price to free cash flow n/m 72.07 21.16
EV/EBITDA n/m 153.05 0.74
EV/Sales 125.94 30.60 10.73
Earnings yield (11.17%) 0.85% (28.84%)
Free cash flow yield (6.80%) 1.39% (23.03%)

Profitability

Metric CYTK PTGX Biotechnology median
Gross margin 87.97% 100.00% 65.16%
Operating margin (1,046.12%) 20.69% 0.00%
Net margin (1,321.12%) 29.40% 0.00%
Free cash flow margin (858.16%) 46.31% 0.00%
Return on equity 329.76% 10.98% (57.72%)
Return on assets (56.76%) 10.34% (49.22%)
Return on invested capital 0.00% 61.84% 0.00%

Growth

Metric CYTK PTGX Biotechnology median
Revenue growth (TTM) (21.07%) 34.81% 5.64%
EPS growth (last fiscal year) (24.33%) (148.46%) —
Revenue growth, 5-year CAGR 9.54% 9.96% 8.40%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric CYTK PTGX Biotechnology median
Debt to equity (6.61) 0.00 0.00
Current ratio 6.66 21.71 4.73
Net debt to EBITDA (0.46) 3.49 0.96

Dividend

Metric CYTK PTGX Biotechnology median
Dividend yield — — 2.10%
Payout ratio 0.00 0.00 0.00

Size

Metric CYTK PTGX Biotechnology median
Market cap 8.98b 8.88b 162.10m

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