Protagonist Therapeutics, Inc.

PTGX Healthcare Biotechnology

Protagonist Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, down 89.4% from fiscal 2024.

Revenue
+3,749.2%
EPS
+549.1%
Free cash flow
+839.7%

Quarter to June 2026, against a year earlier

132.51 2.75 −2.03%
Market cap
$8.8B
P/E
111×
Fwd P/E
31.2×
Dividend yield
—
F-score
4/9
Altman Z
61.55
Beneish M
−7.18
Dividend safety
n/a

Protagonist Therapeutics, Inc. (PTGX) Return on equity

Alert me on Return on equity

Protagonist Therapeutics, Inc.'s return on equity over the twelve months to 30 June 2026 was 11.0%, up 31.2 percentage points from fiscal 2025 (−20.2%). Over the past ten years it has ranged from −125.5% (fiscal 2016) to 74.3% (fiscal 2015); the current reading is higher than 82% of that period. That is above the Biotechnology industry median of −50.1% and above the Healthcare sector median of −26.3%.

Return on equity, annual

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Annual newest first

Period Return on equity Change (points)
FY2025 −20.2% (74.57)
FY2024 54.4% 82.98
FY2023 −28.6% 20.82
FY2022 −49.4% (6.09)
FY2021 −43.3% (6.53)
FY2020 −36.8% 43.41
FY2019 −80.2% (46.81)
FY2018 −33.4% 2.11
FY2017 −35.5% 89.96
FY2016 −125.5% (199.71)

Against its own ten years

Low −125.5% High 74.3%
Ten-year median −35.5%
Current reading's percentile 82

Return on equity against peers

Company Return on equity
CYTK Cytokinetics, Incorporated compare 184.7%
IBRX ImmunityBio, Inc. compare 122.9%
TGTX TG Therapeutics, Inc. compare 100.3%
KRYS Krystal Biotech, Inc. compare 17.5%
PTGX Protagonist Therapeutics, Inc. 11.0%
CAI Caris Life Sciences,�Inc. compare 0.00%
MDGL Madrigal Pharmaceuticals, Inc. compare −24.8%
TWST Twist Bioscience Corporation compare −29.6%
SYRE Spyre Therapeutics, Inc. compare −41.2%
Biotechnology industry median −50.1%
Healthcare sector median −26.3%
Market median 0.51%

What Return on equity is

ROE shows how much profit a company earns for its shareholders on the equity they have in the business.

Annual: Net Income Allotted to Shareholders ÷ Average Common Equity; TTM: Net Income Allotted to Shareholders ÷ Average Common Equity (latest quarter)

The full definition of Return on equity →

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