Vertex Pharmaceuticals Incorporated

VRTX Healthcare Biotechnology

Vertex Pharmaceuticals Incorporated’s revenue for fiscal 2025 (year ended December 2025) was $12.0 billion, up 8.90% from fiscal 2024.

Revenue
+11.9%
EPS
−39.2%
Free cash flow
−52.1%

Quarter to September 2026, against a year earlier

547.43 4.93 +0.91%
Market cap
$137.5B
P/E
34.6×
Fwd P/E
33.2×
Dividend yield
—
F-score
8/9
Altman Z
12.06
Beneish M
−2.17
Dividend safety
n/a

Vertex Pharmaceuticals Incorporated (VRTX) Return on invested capital

Alert me on Return on invested capital

Vertex Pharmaceuticals Incorporated's return on invested capital over the twelve months to 30 September 2026 was 14.9%, down 6.8 percentage points from fiscal 2025 (21.6%). Over the past ten years it has ranged from −37.3% (fiscal 2015) to 75.5% (fiscal 2022); the current reading is higher than 55% of that period. That is above the Biotechnology industry median of 0.00% and above the Healthcare sector median of 0.00%.

Return on invested capital, annual

Embed this chart

Annual newest first

Period Return on invested capital Change (points)
FY2025 21.6% 23.03
FY2024 −1.40% (36.94)
FY2023 35.5% (39.98)
FY2022 75.5% 19.15
FY2021 56.4% (13.18)
FY2020 69.6% 42.97
FY2019 26.6% 5.10
FY2018 21.5% 7.15
FY2017 14.3% 13.41
FY2016 0.92% 38.19

Against its own ten years

Low −37.3% High 75.5%
Ten-year median 21.6%
Current reading's percentile 55

Return on invested capital against peers

Company Return on invested capital
ONC BeOne Medicines Ltd. - Sponsored ADR compare 85.2%
VRTX Vertex Pharmaceuticals Incorporated 14.9%
REGN Regeneron Pharmaceuticals, Inc. compare 11.6%
GMAB Genmab A/S Sponsored ADR compare 6.99%
RPRX Royalty Pharma PLC compare 5.24%
RVMD Revolution Medicines, Inc. compare 0.00%
ARGX argenex SE compare 0.00%
ROIV Roivant Sciences Ltd. compare −34.5%
MRNA Moderna, Inc. compare −93.5%
Biotechnology industry median 0.00%
Healthcare sector median 0.00%
Market median 0.00%

What Return on invested capital is

Return on Invested Capital shows how much after-tax operating profit a company earns on the money its lenders and shareholders have put in.

TTM: (Operating Income × 0.625) ÷ (Shareholders Equity (Total) (latest quarter) + Long Term Debt (Total) (latest quarter) + Current Part of Debt (latest quarter) − Cash & Short Term Investments (latest quarter)); Annual: (Operating Income × 0.625) ÷ (Shareholders Equity (Total) + Long Term Debt (Total) + Current Part of Debt − Cash & Short Term Investments)

The full definition of Return on invested capital →

More on VRTX