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Vertex Pharmaceuticals Incorporated

VRTX Healthcare Biotechnology

Vertex Pharmaceuticals Incorporated’s revenue for fiscal 2025 (year ended December 2025) was $12.0 billion, up 8.90% from fiscal 2024.

Revenue
+11.9%
EPS
−39.2%
Free cash flow
−52.1%

Quarter to September 2026, against a year earlier

547.29 4.79 +0.88%
Market cap
$137.5B
P/E
34.6×
Fwd P/E
33.2×
Dividend yield
—
F-score
8/9
Altman Z
12.06
Beneish M
−2.17
Dividend safety
n/a
Overview Business Profile Earnings & Analysis
Financials
Income Statement Balance Sheet Cash Flow Metrics & Ratios
Segments Valuation Filings

Vertex Pharmaceuticals Incorporated (VRTX) EV/EBITDA

Alert me on EV/EBITDA

As of 5 November 2026, Vertex Pharmaceuticals Incorporated (VRTX) trades at a EV/EBITDA of 29.7×. Over the past ten years it has ranged from 0.0× (June 2025) to 938× (June 2018); the current reading is higher than 69% of that period. That is above the Biotechnology industry median of 0.7× and above the Healthcare sector median of 8.4×.

EV/EBITDA, daily

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Annual newest first

Period EV/EBITDA Change
FY2025 25.0× —
FY2024 0.0× —
FY2023 23.8× 67.49%
FY2022 14.2× (17.31%)
FY2021 17.2× (8.47%)
FY2020 18.7× (54.08%)
FY2019 40.8× (27.54%)
FY2018 56.3× (71.78%)
FY2017 200× (19.40%)
FY2016 248× —

Quarterly newest first

Period EV/EBITDA Change
Sep 2026 28.6× 20.71%
Jun 2026 23.7× 8.97%
Mar 2026 21.8× (13.05%)
Dec 2025 25.0× 11.43%
43 more quarters

Against its own ten years

Low 0.0× High 938×
Ten-year median 20.1×
Current reading's percentile 69

EV/EBITDA against peers

Company EV/EBITDA
ROIV Roivant Sciences Ltd. compare n/m
MRNA Moderna, Inc. compare n/m
RVMD Revolution Medicines, Inc. compare n/m
REGN Regeneron Pharmaceuticals, Inc. compare 16.0×
RPRX Royalty Pharma PLC compare 24.7×
ONC BeOne Medicines Ltd. - Sponsored ADR compare 28.6×
VRTX Vertex Pharmaceuticals Incorporated 29.7×
ARGX argenex SE compare 30.4×
GMAB Genmab A/S Sponsored ADR compare 31.0×
Biotechnology industry median 0.7×
Healthcare sector median 8.4×
Market median 10.9×

What EV/EBITDA is

Enterprise Value over EBITDA tells an investor how the market values a whole company, with debt added and cash taken off, against its operating earnings.

((Stock Price × Shares (Basic, Weighted) (latest quarter)) + (Long Term Debt (Total) (latest quarter) + Current Part of Debt (latest quarter)) − Cash & Short Term Investments (latest quarter)) ÷ EBITDA (TTM)

The full definition of EV/EBITDA →

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