Vertex Pharmaceuticals Incorporated

VRTX Healthcare Biotechnology

Vertex Pharmaceuticals Incorporated’s revenue for fiscal 2025 (year ended December 2025) was $12.0 billion, up 8.90% from fiscal 2024.

Revenue
+11.9%
EPS
−39.2%
Free cash flow
−52.1%

Quarter to September 2026, against a year earlier

547.11 4.61 +0.85%
Market cap
$137.5B
P/E
34.6×
Fwd P/E
33.2×
Dividend yield
—
F-score
8/9
Altman Z
12.06
Beneish M
−2.17
Dividend safety
n/a

Vertex Pharmaceuticals Incorporated (VRTX) Operating margin

Alert me on Operating margin

Vertex Pharmaceuticals Incorporated's operating margin over the twelve months to 30 September 2026 was 33.2%, down 1.5 percentage points from fiscal 2025 (34.8%). Over the past ten years it has ranged from −45.2% (fiscal 2015) to 48.2% (fiscal 2022); the current reading is higher than 64% of that period. That is above the Biotechnology industry median of 0.00% and above the Healthcare sector median of 0.00%.

Operating margin, annual

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Annual newest first

Period Operating margin Change (points)
FY2025 34.8% 36.88
FY2024 −2.11% (40.94)
FY2023 38.8% (9.40)
FY2022 48.2% 11.50
FY2021 36.7% (9.30)
FY2020 46.0% 17.26
FY2019 28.8% 7.93
FY2018 20.8% 15.89
FY2017 4.95% 4.37
FY2016 0.58% 45.81

Quarterly newest first

Period Operating margin Change (points)
Sep 2026 20.7% (16.68)
Jun 2026 37.4% (0.70)
Mar 2026 38.1% 0.30
Dec 2025 37.8% (0.76)
43 more quarters

Against its own ten years

Low −45.2% High 48.2%
Ten-year median 28.8%
Current reading's percentile 49

Operating margin against peers

Company Operating margin
RPRX Royalty Pharma PLC compare 57.1%
VRTX Vertex Pharmaceuticals Incorporated 33.2%
ARGX argenex SE compare 29.3%
REGN Regeneron Pharmaceuticals, Inc. compare 28.8%
GMAB Genmab A/S Sponsored ADR compare 26.0%
ONC BeOne Medicines Ltd. - Sponsored ADR compare 17.8%
MRNA Moderna, Inc. compare −149.0%
RVMD Revolution Medicines, Inc. compare −805.8%
ROIV Roivant Sciences Ltd. compare −7,914.8%
Biotechnology industry median 0.00%
Healthcare sector median 0.00%
Market median 0.00%

What Operating margin is

EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.

EBIT ÷ Revenue

The full definition of Operating margin →

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