Protagonist Therapeutics, Inc.

PTGX Healthcare Biotechnology

Protagonist Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, down 89.4% from fiscal 2024. In the quarter to June 2026, revenue grew 3,749.2%, EPS grew 549.1% and free cash flow grew 839.7%, each against the same quarter a year earlier.

128.75 7.80 −5.71%
Market cap
$8.8B
P/E
106×
Fwd P/E
25.0×
Dividend yield
—
F-score
4/9
Altman Z
61.55
Beneish M
−7.18
Dividend safety
n/a
Dec '25 Dec '24 Dec '23 Dec '22 Dec '21 Dec '20 Dec '19 Dec '18 Dec '17 Dec '16
Piotroski F-Score
4 5 5 4 2 4 1 — — —
P/E ratio
0.00 8.62 0.00 0.00 0.00 0.00 0.00 0.00 0.00 —
P/S ratio
120.66 5.47 29.23 11.62 57.91 24.22 790.27 4.87 0.00 —
Altman Z-Score
61.55 22.48 34.73 6.29 18.20 8.50 (1.37) 2.12 4.41 —
Altman Z″-Score (non-manufacturers)
13.41 15.80 15.38 1.99 5.94 7.92 (2.30) 4.30 3.70 —
P/FCF ratio
99.01 13.00 0.00 0.00 0.00 0.00 0.00 0.00 116.73 —
P/Operating CF
(150.17) (81.45) 78.38 (16.71) (58.81) (36.75) (12.78) (14.85) (26.45) —
Beneish M-Score
(7.18) 29.24 405.14 (3.84) (3.31) 106.46 151.71 (1.24) — —
P/B ratio
9.03 3.52 3.95 2.45 5.28 2.48 2.28 1.34 3.10 —
EV/Sales
108.55 4.53 21.93 6.62 46.32 13.88 256.80 0.70 0.00 —
EV/EBITDA
0.00 7.97 0.00 0.00 0.00 0.00 0.00 0.00 0.00 —
EV/FCF
89.07 10.76 (14.08) (2.76) (11.63) (5.45) (1.40) (0.43) 71.81 —
Current Ratio
12.71 12.48 16.71 7.80 7.74 7.84 4.10 5.26 3.55 12.94
Net Debt/EBITDA
3.49 (1.70) 3.60 1.85 2.70 4.95 1.57 3.10 3.91 2.41
Debt/Equity
0.00 0.00 0.00 0.00 0.00 0.00 0.12 0.00 0.00 0.00
ROE
(20.18%) 54.39% (28.59%) (49.41%) (43.32%) (36.79%) (80.20%) (33.39%) (35.50%) (125.46%)
ROA
(18.42%) 49.91% (26.06%) (42.78%) (37.36%) (27.60%) (52.44%) (25.67%) (28.68%) (69.34%)
ROIC
(208.75%) 61.64% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% 0.00% (205.27%)
Return on Tangible Assets
(24.28%) 50.27% (23.53%) (59.68%) (42.06%) (23.90%) (69.17%) (34.69%) (33.82%) (48.77%)
Average Days of Receivables
0.96 138.63 60.83 0.14 20.89 30.93 10,673.48 54.14 33.04 0.00
Earnings Yield
(2.35%) 11.61% (6.32%) (24.12%) (7.89%) (9.92%) (42.55%) (25.56%) (10.26%) —
Free Cash Flow Yield
1.01% 7.69% (5.33%) (20.60%) (6.88%) (10.52%) (23.28%) (33.51%) 0.86% —
Free Cash Flow per Share
0.88 2.97 (1.25) (2.22) (2.35) (2.12) (1.64) (2.25) 0.18 (4.66)
Book value per Share
9.67 10.97 5.93 4.40 6.48 8.13 3.09 5.03 6.82 13.47
Free Cash Flow
56.08 182.80 (70.84) (108.93) (108.97) (72.95) (42.49) (50.43) 3.21 (30.32)
EV/EBIT
0.00 7.78 0.00 0.00 0.00 0.00 0.00 0.00 0.00 —
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