Axsome Therapeutics, Inc.

AXSM Healthcare Biotechnology

Axsome Therapeutics, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $638.5 million, up 65.5% from fiscal 2024.

Revenue
+51.9%
EPS
+73.9%
Free cash flow
−1,078.3%
Total debt
+4.04%

Quarter to September 2026, against a year earlier

132.46 2.66 +2.05%
Market cap
$6.8B
P/E
0.0×
Fwd P/E
−49.2×
Dividend yield
—
F-score
5/9
Altman Z
6.91
Beneish M
−2.53
Dividend safety
n/a

Axsome Therapeutics, Inc. (AXSM) Return on equity

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Axsome Therapeutics, Inc.'s return on equity over the twelve months to 30 September 2026 was −175.6%, up 76.5 percentage points from fiscal 2025 (−252.1%). Over the past ten years it has ranged from −350.8% (fiscal 2018) to −56.5% (fiscal 2015); the current reading is higher than 27% of that period. That is below the Biotechnology industry median of −50.1% and below the Healthcare sector median of −26.3%.

Return on equity, annual

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Annual newest first

Period Return on equity Change (points)
FY2025 −252.1% (20.48)
FY2024 −231.6% (72.42)
FY2023 −159.2% 139.76
FY2022 −299.0% (97.46)
FY2021 −201.5% (131.15)
FY2020 −70.4% 5.72
FY2019 −76.1% 274.70
FY2018 −350.8% (199.59)
FY2017 −151.2% (71.20)
FY2016 −80.0% (23.51)

Against its own ten years

Low −350.8% High −56.5%
Ten-year median −159.2%
Current reading's percentile 27

Return on equity against peers

Company Return on equity
LGND Ligand Pharmaceuticals Incorporated compare 5.38%
BLTE Belite Bio, Inc. Sponsored ADR compare 0.00%
ORKA Oruka Therapeutics, Inc. compare −18.3%
PRAX Praxis Precision Medicines, Inc. compare −38.9%
IONS Ionis Pharmaceuticals, Inc. compare −105.5%
RYTM Rhythm Pharmaceuticals, Inc. compare −167.5%
AXSM Axsome Therapeutics, Inc. −175.6%
ABVX Abivax SA Sponsored ADR compare −249.8%
MIRM Mirum Pharmaceuticals, Inc. compare −760.0%
Biotechnology industry median −50.1%
Healthcare sector median −26.3%
Market median 0.51%

What Return on equity is

ROE shows how much profit a company earns for its shareholders on the equity they have in the business.

Annual: Net Income Allotted to Shareholders ÷ Average Common Equity; TTM: Net Income Allotted to Shareholders ÷ Average Common Equity (latest quarter)

The full definition of Return on equity →

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