Alnylam Pharmaceuticals, Inc.

ALNY Healthcare Biotechnology

Alnylam Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $3.7 billion, up 65.2% from fiscal 2024.

Revenue
+16.7%
EPS
+747.6%
Free cash flow
−4.76%
Total debt
−2.66%

Quarter to September 2026, against a year earlier

157.21 0.55 +0.35%
Market cap
$21.0B
P/E
7.9×
Fwd P/E
13.5×
Dividend yield
—
F-score
6/9
Altman Z
7.30
Beneish M
−1.95
Dividend safety
n/a

Alnylam Pharmaceuticals, Inc. (ALNY) Return on equity

Alert me on Return on equity

Alnylam Pharmaceuticals, Inc.'s return on equity over the twelve months to 30 September 2026 was 138.1%, up 64.8 percentage points from fiscal 2025 (73.3%). Over the past ten years it has ranged from −526.1% (fiscal 2022) to 362.3% (fiscal 2024); the current reading is higher than 82% of that period. That is above the Biotechnology industry median of −50.1% and above the Healthcare sector median of −26.3%.

Return on equity, annual

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Annual newest first

Period Return on equity Change (points)
FY2025 73.3% (289.01)
FY2024 362.3% 129.89
FY2023 232.4% 758.54
FY2022 −526.1% (419.83)
FY2021 −106.3% (36.39)
FY2020 −69.9% (5.26)
FY2019 −64.7% (15.03)
FY2018 −49.6% (13.09)
FY2017 −36.5% 1.00
FY2016 −37.5% (11.18)

Against its own ten years

Low −526.1% High 362.3%
Ten-year median −37.5%
Current reading's percentile 82

Return on equity against peers

Company Return on equity
ALNY Alnylam Pharmaceuticals, Inc. 138.1%
ASND Ascendis Pharma A/S compare 118.4%
EXEL Exelixis, Inc. compare 44.3%
BBIO BridgeBio Pharma, Inc. compare 26.2%
INCY Incyte Corporation compare 7.84%
JAZZ Jazz Pharmaceuticals PLC compare 5.05%
ROIV Roivant Sciences Ltd. compare −5.47%
BNTX BioNTech SE Sponsored ADR compare −8.29%
INSM Insmed, Inc. compare −72.5%
Biotechnology industry median −50.1%
Healthcare sector median −26.3%
Market median 0.51%

What Return on equity is

ROE shows how much profit a company earns for its shareholders on the equity they have in the business.

Annual: Net Income Allotted to Shareholders ÷ Average Common Equity; TTM: Net Income Allotted to Shareholders ÷ Average Common Equity (latest quarter)

The full definition of Return on equity →

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