Alnylam Pharmaceuticals, Inc.

ALNY Healthcare Biotechnology

Alnylam Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $3.7 billion, up 65.2% from fiscal 2024.

Revenue
+16.7%
EPS
+747.6%
Free cash flow
−4.76%
Total debt
−2.66%

Quarter to September 2026, against a year earlier

157.21 0.55 +0.35%
Market cap
$21.0B
P/E
7.9×
Fwd P/E
13.5×
Dividend yield
—
F-score
6/9
Altman Z
7.30
Beneish M
−1.95
Dividend safety
n/a

Alnylam Pharmaceuticals, Inc. (ALNY) Net margin

Alert me on Net margin

Alnylam Pharmaceuticals, Inc.'s net margin over the twelve months to 30 September 2026 was 52.9%, up 44.4 percentage points from fiscal 2025 (8.45%). Over the past ten years it has ranged from −1,016.6% (fiscal 2018) to 8.45% (fiscal 2025) — the current reading is the highest in ten years. That is above the Biotechnology industry median of 0.00% and above the Healthcare sector median of 0.00%.

Net margin, annual

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Annual newest first

Period Net margin Change (points)
FY2025 8.45% 20.82
FY2024 −12.4% 11.71
FY2023 −24.1% 84.96
FY2022 −109.0% (8.03)
FY2021 −101.0% 73.14
FY2020 −174.2% 229.09
FY2019 −403.2% 613.34
FY2018 −1,016.6% (470.63)
FY2017 −546.0% 323.68
FY2016 −869.6% (163.80)

Quarterly newest first

Period Net margin Change (points)
Sep 2026 148.6% 135.90
Jun 2026 12.7% (4.91)
Mar 2026 17.7% 7.48
Dec 2025 10.2% (13.26)
43 more quarters

Against its own ten years

Low −1,016.6% High 8.45%
Ten-year median −174.2%
Current reading's percentile 100

Net margin against peers

Company Net margin
ASND Ascendis Pharma A/S compare 71.2%
ALNY Alnylam Pharmaceuticals, Inc. 52.9%
EXEL Exelixis, Inc. compare 35.5%
INCY Incyte Corporation compare 6.71%
JAZZ Jazz Pharmaceuticals PLC compare 4.37%
INSM Insmed, Inc. compare −39.9%
BBIO BridgeBio Pharma, Inc. compare −62.6%
BNTX BioNTech SE Sponsored ADR compare −63.8%
ROIV Roivant Sciences Ltd. compare −3,535.0%
Biotechnology industry median 0.00%
Healthcare sector median 0.00%
Market median 1.06%

What Net margin is

Net Profit Margin tells an investor how much of each unit of revenue ends up as profit for shareholders after all costs, interest and taxes.

Net Income Allotted to Shareholders ÷ Revenue

The full definition of Net margin →

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