Alnylam Pharmaceuticals, Inc.

ALNY Healthcare Biotechnology

Alnylam Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $3.7 billion, up 65.2% from fiscal 2024. In the quarter to June 2026, revenue grew 66.9%, EPS grew 341.2%, free cash flow grew 152.8% and total debt fell 1.51%, each against the same quarter a year earlier. Member of the Nasdaq 100; revenue growth for five consecutive years.

231.83 2.20 −0.94%
Market cap
$31.3B
P/E
39.5×
Fwd P/E
39.6×
Dividend yield
—
F-score
6/9
Altman Z
7.30
Beneish M
−1.95
Dividend safety
n/a
Dec '25 Dec '24 Dec '23 Dec '22 Dec '21 Dec '20 Dec '19 Dec '18 Dec '17 Dec '16
Piotroski F-Score
6 5 5 3 3 4 2 2 5 2
P/E ratio
163.12 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
P/S ratio
14.03 13.36 13.32 27.40 23.79 30.32 57.26 97.91 132.79 70.13
Altman Z-Score
7.30 2.90 1.84 2.30 2.14 1.92 5.20 12.72 28.92 3.22
Altman Z″-Score (non-manufacturers)
(0.11) (2.60) (3.07) (4.01) (2.17) (1.67) (2.40) (0.09) 8.26 (0.91)
P/FCF ratio
111.94 0.00 580.47 0.00 0.00 0.00 0.00 0.00 0.00 0.00
P/Operating CF
318.51 (317.31) (817.18) (215.38) (133.79) (121.36) (64.21) (48.74) (115.87) (42.22)
Beneish M-Score
(1.95) (2.50) (2.66) (3.07) (3.03) 3.21 (1.52) (3.71) (2.25) (2.03)
P/B ratio
66.01 447.73 0.00 0.00 34.15 14.71 8.75 5.63 6.76 3.59
EV/Sales
13.51 12.62 12.54 26.27 21.71 26.91 51.53 83.83 114.32 60.02
EV/EBITDA
90.08 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
EV/FCF
107.85 (666.08) 546.65 (44.43) (25.52) (19.35) (27.05) (9.11) (21.11) (7.60)
Current Ratio
2.76 2.78 3.08 3.51 4.04 4.47 4.87 6.69 12.23 5.10
Net Debt/EBITDA
(3.41) 13.89 6.22 1.59 2.84 2.23 1.42 1.32 3.40 1.16
Debt/Equity
1.28 15.27 (4.63) (6.43) 1.15 0.19 0.19 0.02 0.02 0.16
ROE
73.28% 362.29% 232.40% (526.14%) (106.31%) (69.92%) (64.66%) (49.63%) (36.54%) (37.54%)
ROA
6.82% (6.89%) (11.94%) (31.47%) (24.19%) (29.58%) (44.64%) (42.67%) (30.14%) (30.96%)
ROIC
0.00% 0.00% 0.00% 0.00% 0.00% 0.00% (328.88%) (205.47%) (295.38%) (59.85%)
Return on Tangible Assets
10.13% (10.65%) (17.33%) (46.21%) (32.61%) (34.41%) (49.55%) (56.75%) (27.23%) (62.64%)
Average Days of Receivables
76.42 65.80 65.44 83.72 85.85 446.14 71.44 91.41 138.03 180.60
Earnings Yield
0.61% (0.92%) (1.81%) (3.98%) (4.25%) (5.73%) (7.07%) (10.37%) (4.10%) (12.40%)
Free Cash Flow Yield
0.89% (0.14%) 0.17% (2.16%) (3.57%) (4.59%) (3.33%) (9.40%) (4.08%) (11.26%)
Free Cash Flow per Share
3.55 (0.33) 0.34 (5.04) (6.06) (5.96) (3.83) (6.85) (5.38) (4.35)
Book value per Share
6.02 0.53 (1.77) (1.30) 4.97 8.84 13.17 12.94 19.51 10.75
Free Cash Flow
465.38 (42.59) 41.95 (613.33) (718.06) (685.32) (418.58) (689.50) (486.99) (372.26)
EV/EBIT
100.07 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
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