Alnylam Pharmaceuticals, Inc.

ALNY Healthcare Biotechnology

Alnylam Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $3.7 billion, up 65.2% from fiscal 2024.

Revenue
+16.7%
EPS
+747.6%
Free cash flow
−4.76%
Total debt
−2.66%

Quarter to September 2026, against a year earlier

156.74 0.08 +0.05%
Market cap
$21.0B
P/E
7.9×
Fwd P/E
13.5×
Dividend yield
—
F-score
6/9
Altman Z
7.30
Beneish M
−1.95
Dividend safety
n/a

Alnylam Pharmaceuticals, Inc. (ALNY) EV/EBITDA

Alert me on EV/EBITDA

As of 5 November 2026, Alnylam Pharmaceuticals, Inc. (ALNY) trades at a EV/EBITDA of 17.8×. Over the past ten years it has ranged from 0.0× (September 2025) to 256× (August 2024); the current reading is higher than 89% of that period. That is above the Biotechnology industry median of 0.7× and above the Healthcare sector median of 8.4×.

EV/EBITDA, daily

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Annual newest first

Period EV/EBITDA Change
FY2025 91.0× —
FY2024 0.0× —
FY2023 0.0× —
FY2022 0.0× —
FY2021 0.0× —
FY2020 0.0× —
FY2019 0.0× —
FY2018 0.0× —
FY2017 0.0× —
FY2016 0.0× —

Quarterly newest first

Period EV/EBITDA Change
Sep 2026 29.5× (18.04%)
Jun 2026 36.0× (30.86%)
Mar 2026 52.0× (42.81%)
Dec 2025 91.0× (49.88%)
43 more quarters

Against its own ten years

Low 0.0× High 256×
Ten-year median 0.0×
Current reading's percentile 89

EV/EBITDA against peers

Company EV/EBITDA
ROIV Roivant Sciences Ltd. compare n/m
BNTX BioNTech SE Sponsored ADR compare n/m
BBIO BridgeBio Pharma, Inc. compare n/m
INSM Insmed, Inc. compare n/m
JAZZ Jazz Pharmaceuticals PLC compare 15.2×
EXEL Exelixis, Inc. compare 15.6×
ALNY Alnylam Pharmaceuticals, Inc. 17.8×
INCY Incyte Corporation compare 27.9×
ASND Ascendis Pharma A/S compare 49.5×
Biotechnology industry median 0.7×
Healthcare sector median 8.4×
Market median 10.9×

What EV/EBITDA is

Enterprise Value over EBITDA tells an investor how the market values a whole company, with debt added and cash taken off, against its operating earnings.

((Stock Price × Shares (Basic, Weighted) (latest quarter)) + (Long Term Debt (Total) (latest quarter) + Current Part of Debt (latest quarter)) − Cash & Short Term Investments (latest quarter)) ÷ EBITDA (TTM)

The full definition of EV/EBITDA →

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