Madrigal Pharmaceuticals, Inc.

MDGL Healthcare Biotechnology

Madrigal Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $958.4 million, up 432.1% from fiscal 2024.

Revenue
+50.1%
EPS
+147.3%
Free cash flow
+53.5%
Total debt
+0.45%

Quarter to September 2026, against a year earlier

390.52 9.58 −2.39%
Market cap
$9.3B
P/E
0.0×
Fwd P/E
−68.8×
Dividend yield
—
F-score
n/a
Altman Z
10.48
Beneish M
0.50
Dividend safety
n/a

Madrigal Pharmaceuticals, Inc. (MDGL) Net margin

Alert me on Net margin

Madrigal Pharmaceuticals, Inc.'s net margin over the twelve months to 30 September 2026 was −10.9%, up 19.2 percentage points from fiscal 2025 (−30.1%). Over the past ten years it has ranged from −258.6% (fiscal 2024) to 0.00% (fiscal 2023); the current reading is higher than 18% of that period. That is below the Biotechnology industry median of 0.00% and below the Healthcare sector median of 0.00%.

Net margin, annual

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Annual newest first

Period Net margin Change (points)
FY2025 −30.1% 228.56
FY2024 −258.6% (258.64)
FY2023 0.00% 0.00
FY2022 0.00% 0.00
FY2021 0.00% 0.00
FY2020 0.00% 0.00
FY2019 0.00% 0.00
FY2018 0.00% 0.00
FY2017 0.00% 0.00
FY2016 0.00% 0.00

Quarterly newest first

Period Net margin Change (points)
Sep 2026 12.9% 28.77
Jun 2026 −15.9% 14.41
Mar 2026 −30.3% (12.08)
Dec 2025 −18.2% 21.51
43 more quarters

Against its own ten years

Low −258.6% High 0.00%
Ten-year median 0.00%
Current reading's percentile 18

Net margin against peers

Company Net margin
TGTX TG Therapeutics, Inc. compare 55.2%
KRYS Krystal Biotech, Inc. compare 47.9%
PTGX Protagonist Therapeutics, Inc. compare 29.4%
CAI Caris Life Sciences,�Inc. compare 9.16%
SYRE Spyre Therapeutics, Inc. compare 0.00%
MDGL Madrigal Pharmaceuticals, Inc. −10.9%
TWST Twist Bioscience Corporation compare −31.7%
IBRX ImmunityBio, Inc. compare −598.6%
CYTK Cytokinetics, Incorporated compare −686.6%
Biotechnology industry median 0.00%
Healthcare sector median 0.00%
Market median 1.06%

What Net margin is

Net Profit Margin tells an investor how much of each unit of revenue ends up as profit for shareholders after all costs, interest and taxes.

Net Income Allotted to Shareholders ÷ Revenue

The full definition of Net margin →

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