Friday 6 November 2026 Export SEPN’s income statement to Excel — free account

Septerna, Inc.

SEPN Healthcare Biotechnology

Septerna, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, up 4,174.5% from fiscal 2024.

Revenue: +22,375.6%
EPS: +48.2%
Free cash flow: −9.01%

Quarter to June 2026, against a year earlier

48.95 1.60 +3.38%

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Market cap: $2.2B
P/E: 0.0×
Fwd P/E: −32.6×
Dividend yield: —
F-score: 5/9
Altman Z: 3.41
Beneish M: 32.85
Dividend safety: n/a

Overview

Septerna, Inc. (SEPN) P/S ratio

Alert me on P/S ratio

As of 5 November 2026, Septerna, Inc. (SEPN) trades at a P/S ratio of 21.8×. Over the past ten years it has ranged from 14.3× (April 2026) to 1,104× (September 2025); the current reading is higher than 28% of that period. That is above the Biotechnology industry median of 9.2× and above the Healthcare sector median of 3.5×.

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<iframe src="https://stockrow.com/embed/SEPN/ps-ratio" width="100%" height="360" style="border:0" loading="lazy" title="Septerna, Inc. P/S ratio, 10 years"></iframe>
<p style="font-size:12px">Source: <a href="https://stockrow.com/SEPN/metrics/ps-ratio">Septerna, Inc. (SEPN) P/S ratio — stockrow.com</a></p>

Period	P/S ratio	Change
FY2025	26.9×	(87.26%)
FY2024	211×	260.96%
FY2023	58.4×	—

Period	P/S ratio	Change
Jun 2026	15.3×	2.48%
Mar 2026	14.9×	(44.57%)
Dec 2025	26.9×	(29.03%)
Sep 2025	37.8×	(94.12%)
7 more quarters	Free account

Against its own ten years

Low 14.3× High 1,104×

Ten-year median 51.2×

Current reading's percentile 28

Company	P/S ratio
VERA Vera Therapeutics, Inc. compare	n/m
BHVN Biohaven Ltd. compare	2.1×
AUPH Aurinia Pharmaceuticals Inc compare	6.7×
LKFT Lakefront Biotherapeutics - Sponsored ADR compare	7.9×
VCEL Vericel Corporation compare	8.1×
SEPN Septerna, Inc.	21.8×
PVLA Palvella Therapeutics, Inc. compare	54.1×
ZYME Zymeworks Inc. compare	56.8×
IMNM Immunome, Inc. compare	162×
Biotechnology industry median	9.2×
Healthcare sector median	3.5×
Market median	1.9×

What P/S ratio is

Price to Sales Ratio shows how much investors pay for each dollar of a company’s annual sales, whether or not it is profitable.

(Stock Price × Shares (Basic, Weighted) (latest quarter)) ÷ Revenue (TTM)

The full definition of P/S ratio →

Septerna, Inc. (SEPN) P/S ratio

P/S ratio, daily

Annual newest first

Quarterly newest first

Against its own ten years

P/S ratio against peers

What P/S ratio is

More on SEPN

P/S ratio, daily

Annual newest first

Quarterly newest first

Against its own ten years

P/S ratio against peers

What P/S ratio is

More on SEPN

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