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Septerna, Inc. (SEPN) vs Trevi Therapeutics, Inc. (TRVI)

Septerna, Inc. and Trevi Therapeutics, Inc. are both Biotechnology companies. Septerna, Inc. and Trevi Therapeutics, Inc. are of similar size ($1.8B and $1.7B). Trevi Therapeutics, Inc. has the higher net margin (0.00% vs −24.5%) and the lower return on invested capital (−1,412.1% vs −189.0%). Across the 13 metrics below, Septerna, Inc. leads on 9 and Trevi Therapeutics, Inc. on 4.

Valuation

Metric SEPN TRVI Biotechnology median
P/E n/m n/m 8.50
P/S 16.42 n/m 9.71
P/B 4.20 5.78 2.13
Price to free cash flow 13.81 n/m 20.82
EV/EBITDA n/m n/m 0.64
EV/Sales 12.66 n/m 9.21
Earnings yield (1.50%) (2.86%) (33.15%)
Free cash flow yield 7.24% (2.84%) (25.50%)

Profitability

Metric SEPN TRVI Biotechnology median
Gross margin 100.00% 0.00% 65.16%
Operating margin (44.04%) 0.00% 0.00%
Net margin (24.51%) 0.00% 0.00%
Free cash flow margin 118.93% 0.00% 0.00%
Return on equity (6.34%) (19.66%) (56.36%)
Return on assets (4.94%) (18.97%) (48.04%)
Return on invested capital (189.01%) (1,412.11%) 0.00%

Growth

Metric SEPN TRVI Biotechnology median
Revenue growth (TTM) 13,520.11% — 6.02%
EPS growth (last fiscal year) 84.85% 31.91% 30.26%
Revenue growth, 5-year CAGR — — 9.41%
Net income growth, 5-year CAGR — 0.00% 0.00%

Health

Metric SEPN TRVI Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 4.99 37.28 4.72
Net debt to EBITDA 5.86 3.83 0.96

Dividend

Metric SEPN TRVI Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric SEPN TRVI Biotechnology median
Market cap 1.75b 1.73b 135.18m

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