Septerna, Inc.

SEPN Healthcare Biotechnology

Septerna, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, up 4,174.5% from fiscal 2024.

Revenue
+22,375.6%
EPS
+48.2%
Free cash flow
−9.01%

Quarter to June 2026, against a year earlier

49.54 2.19 +4.63%
Market cap
$2.2B
P/E
0.0×
Fwd P/E
−32.6×
Dividend yield
—
F-score
5/9
Altman Z
3.41
Beneish M
32.85
Dividend safety
n/a

Septerna, Inc. (SEPN) Free cash flow margin

Alert me on Free cash flow margin

Septerna, Inc.'s free cash flow margin over the twelve months to 30 June 2026 was 118.9%, down 146.9 percentage points from fiscal 2025 (265.9%). That is above the Biotechnology industry median of 0.00% and above the Healthcare sector median of 0.00%.

Free cash flow margin, annual

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Annual newest first

Period Free cash flow margin Change (points)
FY2025 265.9% 4,633.13
FY2024 −4,367.3% 6,626.78
FY2023 −10,994.0% —

Free cash flow margin against peers

Company Free cash flow margin
SEPN Septerna, Inc. 118.9%
AUPH Aurinia Pharmaceuticals Inc compare 55.0%
VCEL Vericel Corporation compare 17.9%
IMNM Immunome, Inc. compare 0.00%
VERA Vera Therapeutics, Inc. compare 0.00%
LKFT Lakefront Biotherapeutics - Sponsored ADR compare 0.00%
BHVN Biohaven Ltd. compare 0.00%
PVLA Palvella Therapeutics, Inc. compare 0.00%
ZYME Zymeworks Inc. compare −324.7%
Biotechnology industry median 0.00%
Healthcare sector median 0.00%
Market median 0.00%

What Free cash flow margin is

Free Cash Flow Margin tells an investor how much of each sale turns into cash the company keeps after paying for investment in its assets.

(Operating Cash Flow + Property, Plant, Equipment Change (Net) + Intangible Assets Change (Net)) ÷ Revenue

The full definition of Free cash flow margin →

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