Friday 6 November 2026 Export SEPN’s income statement to Excel — free account

Septerna, Inc.

SEPN Healthcare Biotechnology

Septerna, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, up 4,174.5% from fiscal 2024.

Revenue: +22,375.6%
EPS: +48.2%
Free cash flow: −9.01%

Quarter to June 2026, against a year earlier

48.84 1.49 +3.15%

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Market cap: $2.2B
P/E: 0.0×
Fwd P/E: −32.6×
Dividend yield: —
F-score: 5/9
Altman Z: 3.41
Beneish M: 32.85
Dividend safety: n/a

Overview

Septerna, Inc. (SEPN) EV/EBITDA

Alert me on EV/EBITDA

Septerna, Inc. has no meaningful EV/EBITDA: its trailing twelve-month EBITDA is negative. Over the past ten years it has ranged from 0.0× (November 2026) to 3.7× (February 2025) — the current reading is the lowest in ten years.

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<iframe src="https://stockrow.com/embed/SEPN/ev-ebitda" width="100%" height="360" style="border:0" loading="lazy" title="Septerna, Inc. EV/EBITDA, 10 years"></iframe>
<p style="font-size:12px">Source: <a href="https://stockrow.com/SEPN/metrics/ev-ebitda">Septerna, Inc. (SEPN) EV/EBITDA — stockrow.com</a></p>

Period	EV/EBITDA	Change
FY2025	0.0×	—
FY2024	1.6×	34.44%
FY2023	1.2×	—

Period	EV/EBITDA	Change
Jun 2026	0.0×	—
Mar 2026	0.0×	—
Dec 2025	0.0×	—
Sep 2025	0.0×	—
7 more quarters	Free account

Against its own ten years

Low 0.0× High 3.7×

Ten-year median 0.0×

Current reading's percentile 73

Company	EV/EBITDA
PVLA Palvella Therapeutics, Inc. compare	n/m
BHVN Biohaven Ltd. compare	n/m
ZYME Zymeworks Inc. compare	n/m
SEPN Septerna, Inc.	n/m
VERA Vera Therapeutics, Inc. compare	n/m
IMNM Immunome, Inc. compare	n/m
LKFT Lakefront Biotherapeutics - Sponsored ADR compare	0.9×
AUPH Aurinia Pharmaceuticals Inc compare	10.5×
VCEL Vericel Corporation compare	79.1×
Biotechnology industry median	0.7×
Healthcare sector median	8.4×
Market median	10.9×

What EV/EBITDA is

Enterprise Value over EBITDA tells an investor how the market values a whole company, with debt added and cash taken off, against its operating earnings.

((Stock Price × Shares (Basic, Weighted) (latest quarter)) + (Long Term Debt (Total) (latest quarter) + Current Part of Debt (latest quarter)) − Cash & Short Term Investments (latest quarter)) ÷ EBITDA (TTM)

The full definition of EV/EBITDA →

Septerna, Inc. (SEPN) EV/EBITDA

EV/EBITDA, daily

Annual newest first

Quarterly newest first

Against its own ten years

EV/EBITDA against peers

What EV/EBITDA is

More on SEPN

EV/EBITDA, daily

Annual newest first

Quarterly newest first

Against its own ten years

EV/EBITDA against peers

What EV/EBITDA is

More on SEPN

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