Septerna, Inc.

SEPN Healthcare Biotechnology

Septerna, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, up 4,174.5% from fiscal 2024.

Revenue
+22,375.6%
EPS
+48.2%
Free cash flow
−9.01%

Quarter to June 2026, against a year earlier

49.50 2.15 +4.54%
Market cap
$2.2B
P/E
0.0×
Fwd P/E
−32.6×
Dividend yield
—
F-score
5/9
Altman Z
3.41
Beneish M
32.85
Dividend safety
n/a

Septerna, Inc. (SEPN) EV/Sales

Alert me on EV/Sales

As of 5 November 2026, Septerna, Inc. (SEPN) trades at a EV/Sales of 18.1×. Over the past ten years it has ranged from −276× (February 2025) to 654× (September 2025); the current reading is higher than 67% of that period. That is above the Biotechnology industry median of 9.0× and above the Healthcare sector median of 3.5×.

EV/Sales, daily

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Annual newest first

Period EV/Sales Change
FY2025 18.3× —
FY2024 −116× —
FY2023 −87.3× —

Quarterly newest first

Period EV/Sales Change
Jun 2026 11.5× 14.01%
Mar 2026 10.1× (45.06%)
Dec 2025 18.3× 12.40%
Sep 2025 16.3× (91.55%)
7 more quarters

Against its own ten years

Low −276× High 654×
Ten-year median 14.4×
Current reading's percentile 67

EV/Sales against peers

What EV/Sales is

EV/Sales tells an investor how the value of a whole company, counting its debt and cash, compares with the sales it brings in.

((Stock Price × Shares (Basic, Weighted) (latest quarter)) + (Long Term Debt (Total) (latest quarter) + Current Part of Debt (latest quarter)) − Cash & Short Term Investments (latest quarter)) ÷ Revenue (TTM)

The full definition of EV/Sales →

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