Friday 6 November 2026 Export SEPN’s income statement to Excel — free account

Septerna, Inc.

SEPN Healthcare Biotechnology

Septerna, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, up 4,174.5% from fiscal 2024.

Revenue: +22,375.6%
EPS: +48.2%
Free cash flow: −9.01%

Quarter to June 2026, against a year earlier

48.95 1.60 +3.38%

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Market cap: $2.2B
P/E: 0.0×
Fwd P/E: −32.6×
Dividend yield: —
F-score: 5/9
Altman Z: 3.41
Beneish M: 32.85
Dividend safety: n/a

Overview

Septerna, Inc. (SEPN) P/B ratio

Alert me on P/B ratio

As of 5 November 2026, Septerna, Inc. (SEPN) trades at a P/B ratio of 5.6×. Over the past ten years it has ranged from 0.0× (December 2024) to 5.6× (August 2026); the current reading is higher than 100% of that period. That is above the Biotechnology industry median of 2.0× and above the Healthcare sector median of 2.3×.

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<iframe src="https://stockrow.com/embed/SEPN/pb-ratio" width="100%" height="360" style="border:0" loading="lazy" title="Septerna, Inc. P/B ratio, 10 years"></iframe>
<p style="font-size:12px">Source: <a href="https://stockrow.com/SEPN/metrics/pb-ratio">Septerna, Inc. (SEPN) P/B ratio — stockrow.com</a></p>

Period	P/B ratio	Change
FY2025	3.2×	499.18%
FY2024	0.5×	—
FY2023	0.0×	—

Period	P/B ratio	Change
Jun 2026	3.9×	37.25%
Mar 2026	2.8×	(12.04%)
Dec 2025	3.2×	50.57%
Sep 2025	2.1×	73.54%
7 more quarters	Free account

Against its own ten years

Low 0.0× High 5.6×

Ten-year median 2.5×

Current reading's percentile 100

Company	P/B ratio
BHVN Biohaven Ltd. compare	n/m
LKFT Lakefront Biotherapeutics - Sponsored ADR compare	0.6×
AUPH Aurinia Pharmaceuticals Inc compare	3.3×
IMNM Immunome, Inc. compare	3.9×
VERA Vera Therapeutics, Inc. compare	5.3×
SEPN Septerna, Inc.	5.6×
VCEL Vericel Corporation compare	6.8×
PVLA Palvella Therapeutics, Inc. compare	10.4×
ZYME Zymeworks Inc. compare	26.2×
Biotechnology industry median	2.0×
Healthcare sector median	2.3×
Market median	1.7×

What P/B ratio is

Price to Book Value tells an investor how much the market pays for a company’s shares relative to the accounting net worth that belongs to common shareholders.

Stock Price ÷ (Common Equity (Total) (latest quarter) ÷ Shares (Basic, Weighted) (latest quarter))

The full definition of P/B ratio →

Septerna, Inc. (SEPN) P/B ratio

P/B ratio, daily

Annual newest first

Quarterly newest first

Against its own ten years

P/B ratio against peers

What P/B ratio is

More on SEPN

P/B ratio, daily

Annual newest first

Quarterly newest first

Against its own ten years

P/B ratio against peers

What P/B ratio is

More on SEPN

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