Septerna, Inc.

SEPN Healthcare Biotechnology

Septerna, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $46.0 million, up 4,174.5% from fiscal 2024. In the quarter to June 2026, revenue grew 22,375.6%, EPS grew 48.2% and free cash flow fell 9.01%, each against the same quarter a year earlier.

36.05 1.40 −3.74%
Market cap
$1.8B
P/E
0.0×
Fwd P/E
−17.5×
Dividend yield
—
F-score
5/9
Altman Z
3.41
Beneish M
32.85
Dividend safety
n/a
Dec '25 Dec '24 Dec '23
Piotroski F-Score
5 — —
P/E ratio
0.00 0.00 0.00
Altman Z-Score
3.41 3.68 —
P/S ratio
26.85 210.70 58.37
Altman Z″-Score (non-manufacturers)
3.75 14.99 4.01
P/FCF ratio
10.10 0.00 0.00
Beneish M-Score
32.85 2.67 —
P/Operating CF
(82.33) (10.81) (3.11)
P/B ratio
3.23 0.54 0.00
EV/Sales
18.34 (115.74) (87.31)
EV/EBITDA
0.00 1.57 1.17
EV/FCF
6.90 2.65 2.21
Current Ratio
4.73 27.77 16.30
Net Debt/EBITDA
5.86 4.42 (30.27)
Debt/Equity
0.00 0.00 0.00
ROE
(12.19%) (37.62%) 0.00%
ROA
(9.29%) (24.45%) 0.00%
ROIC
0.00% (73.08%) 0.00%
Return on Tangible Assets
(14.88%) (20.57%) 0.51%
Average Days of Receivables
82.26 58.06 55,054.57
Earnings Yield
(3.98%) (97.90%) (127.24%)
Free Cash Flow Yield
9.90% (20.73%) (67.71%)
Free Cash Flow per Share
2.76 (4.75) (8.61)
Book value per Share
8.63 42.47 (19.89)
Free Cash Flow
122.17 (46.95) (16.60)
EV/EBIT
0.00 1.54 1.15
Other line items

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Columns are period end dates