Ascendis Pharma A/S ASND
- Market cap
- $15.7B
- P/E
- 16.3×
Follow ASND
Target Price Range
Analyst price targets
Free account| 2016 | 2017 | 2018 | 2019 | 2020 | 2021 | 2022 | 2023 | 2024 | 2025 | 2026 | 2027 | 2028 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 11.92 | 19.60 | 38.28 | 59.58 | 92.00 | 109.36 | 61.58 | 64.33 | 111.09 | 118.03 |
Analyst estimates 2026–2028 Powerpack |
Low Price
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| 21.79 | 42.00 | 76.99 | 140.15 | 183.98 | 178.71 | 137.40 | 129.43 | 161.00 | 229.94 |
High Price
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| 101 | 137 | 216 | 330 | 482 | 639 | 797 | 879 | 1,017 | 1,189 |
Employees
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| 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Revenue/Emp
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| 5 | 2 | 12 | 15 | 8 | 9 | 54 | 289 | 393 | 815 |
Revenue
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| 100.00% | 100.00% | 100.00% | 100.00% | 100.00% | 54.71% | 76.28% | 83.36% | 87.83% | 86.82% |
Gross Margin
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| (76) | (141) | (154) | (244) | (479) | (454) | (609) | (513) | (404) | (241) |
EBT
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| (1,492.23%) | (8,128.83%) | (1,233.25%) | (1,631.78%) | (6,028.69%) | (4,936.26%) | (1,129.12%) | (177.77%) | (102.64%) | (29.53%) |
EBT Margin
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| (76) | (140) | (154) | (244) | (479) | (454) | (614) | (521) | (409) | (258) |
Net Income
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| 1 | 1 | 1 | 7 | 11 | 18 | 19 | 20 | 19 | 20 |
Depreciation
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| 0.19 | 0.05 | 0.30 | 0.32 | 0.16 | 0.17 | 0.96 | 5.13 | 6.80 | 13.44 |
Revenue/Sh
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| (2.85) | (4.33) | (3.74) | (5.25) | (9.46) | (8.28) | (10.96) | (9.24) | (7.07) | (4.25) |
Earnings/Sh
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| (2.51) | (3.20) | (3.99) | (4.24) | (6.13) | (9.02) | (9.31) | (8.99) | (5.72) | 1.01 |
Cash Flow/Sh
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| (0.03) | (0.03) | (0.08) | (0.12) | (0.37) | (0.52) | (0.09) | (0.05) | (0.01) | (0.16) |
Capex/Sh
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| (2.53) | (3.23) | (4.07) | (4.36) | (6.50) | (9.54) | (9.41) | (9.03) | (5.73) | 0.85 |
Free CF/Sh
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| 7.36 | 6.29 | 8.05 | 14.38 | 18.93 | 19.09 | 4.95 | (2.80) | (1.98) | (3.04) |
Book Value/Sh
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| 27 | 34 | 41 | 47 | 51 | 55 | 56 | 56 | 58 | 61 |
Shares
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| 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 | 0.00 |
PE Ratio
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| 103.77 | 773.87 | 205.98 | 431.91 | 1,062.89 | 800.73 | 125.55 | 24.87 | 20.25 | 15.86 |
PS Ratio
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| 2.71 | 6.32 | 7.78 | 9.67 | 8.81 | 7.05 | 24.40 | 0.00 | 0.00 | 0.00 |
PB Ratio
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| 64.62 | 646.19 | 179.72 | 389.93 | 973.61 | 725.97 | 121.11 | 25.41 | 21.07 | 16.22 |
EV/Sales
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| (4.89) | (10.29) | (13.44) | (28.80) | (23.50) | (12.78) | (12.38) | (14.43) | (24.99) | 257.17 |
EV/FCF
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| (67) | (107) | (164) | (197) | (310) | (494) | (522) | (506) | (331) | 61 |
Op' Cash Flow
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| (1) | (1) | (3) | (6) | (19) | (29) | (5) | (3) | (1) | (10) |
Capex
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| (67) | (109) | (167) | (203) | (329) | (523) | (527) | (508) | (332) | 51 |
FCF
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| 189 | 204 | 300 | 631 | 785 | 835 | 793 | 547 | 166 | 45 |
Working Cap'
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| — | — | — | 41 | 112 | 119 | 536 | 590 | 927 | 986 |
Total Debt
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| (200) | (221) | (328) | (629) | (709) | (688) | (239) | 158 | 321 | 289 |
Net Debt
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| 195 | 212 | 331 | 669 | 958 | 1,045 | 277 | (158) | (114) | (184) |
Sh' Equity
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| (42.51%) | (62.41%) | (49.95%) | (43.04%) | (50.99%) | (37.77%) | (50.54%) | (51.04%) | (37.71%) | (18.76%) |
ROA
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| 0.00% | 0.00% | (4,420.67%) | (397.86%) | (94.80%) | (93.45%) | (968.11%) | (84,748.35%) | (91.04%) | (91.65%) |
ROIC
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| (46.08%) | (68.81%) | (56.66%) | (48.86%) | (58.84%) | (45.30%) | (92.90%) | (870.08%) | 300.75% | 172.80% |
ROE
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Ascendis Pharma A/S peers in Biotechnology
| Company | Market cap | P/E | Compare |
|---|---|---|---|
| JAZZ Jazz Pharmaceuticals PLC | $15.3B | 15.6× | Compare |
| EXEL Exelixis, Inc. | $14.4B | 17.6× | Compare |
| SMMT Summit Therapeutics PLC | $13.1B | 0.0× | Compare |
| BBIO BridgeBio Pharma, Inc. | $13.1B | 0.0× | Compare |
| Company | Market cap | P/E | Compare |
|---|---|---|---|
| HALO Halozyme Therapeutics, Inc. | $13.1B | 32.4× | Compare |
| CORT Corcept Therapeutics Incorporated | $12.9B | 223× | Compare |
| BMRN BioMarin Pharmaceutical Inc. | $12.0B | 159× | Compare |
| MDGL Madrigal Pharmaceuticals, Inc. | $11.9B | 0.0× | Compare |
Ascendis Pharma A/S (ASND) key facts
- Ascendis Pharma A/S (ASND) is a Biotechnology company in the Healthcare sector, traded in the US as an ADR.
- Ascendis Pharma A/S’s revenue for fiscal 2025 (year ended December 2025) was $814.8 million, up 107.1% from fiscal 2024.
- Ascendis Pharma A/S reported a net loss of $258.0 million, or a loss of $4.25 per share, for fiscal 2025.
- As of September 25, 2026, ASND traded at $225.60, a market capitalization of $15.7 billion.
- At that price the stock trades at 16.3× trailing-twelve-month earnings and 12.0× sales.
- Return on equity was 172.8% and debt-to-equity 0.31.
Ascendis Pharma A/S (ASND) Latest News
20 Sep
Ascendis Pharma A/S announced a board-authorized buyback of up to $400 million of ordinary shares. The plan is optional and can be paused or altered, depending on market conditions. In the quarter ended June 30, product revenue rose to €315 million, up 105% YoY, led by YORVIPATH at €252 million. Operating profit swung to €220 million from a year-ago loss, helped by a €158 million sale of a priority-review voucher; non-IFRS €92 million. First-half 2026 operating cash flow reached €274 million; cash on hand was €812 million as of June 30. All €575 million of convertible notes converted on May 6, removing debt to equity. Costs rose with expansion: SG&A €173 million and R&D up. Short interest about 7.6%; forward P/E near 21. The buyback’s ceiling is not a commitment; actual action will depend on pricing and conditions, with the business still reliant on YORVIPATH and newer launches like YUVIWEL. Buyback is a non-binding option signaling confidence but unlikely to drastically alter trajectory; core risks and growth drivers remain in product demand and costs.
19 Sep
Ascendis Pharma (ASND) regains exclusive rights to key TransCon metabolic programs. Regaining exclusive rights to key TransCon metabolic programs strengthens pipeline control and revenue potential.
17 Sep
Ascendis Pharma will regain rights to its metabolic drug, prompting questions on whether the benefits of greater ownership outweigh the costs. Regaining full ownership of metabolic drug rights can substantially alter Ascendis Pharma's development path and market position.
16 Sep
Ascendis Pharma terminated collaboration with Novo Nordisk. Wedbush states Ascendis has capacity to execute alone. Termination of Novo Nordisk collaboration enables independent execution per Wedbush view.
15 Sep
Ascendis Pharma regains rights to obesity drug and discloses $400 million share buyback. Regaining obesity drug rights plus large buyback represent major strategic moves likely to shift company trajectory and investor sentiment.
14 Sep
Ascendis Pharma regains rights to TransCon technology in metabolic and cardiovascular diseases. Regaining full control of TransCon technology in core therapeutic areas strengthens Ascendis strategic positioning and development options.
Ascendis Pharma A/S announces a planned $400 million share repurchase program. A $400 million share repurchase program signals management confidence and can support stock price through reduced share count.
10 Sep
Ascendis Pharma A/S announced its growth drug shows benefits in infants. Positive trial data on growth drug benefits in infants signals major pipeline progress and potential regulatory gains for Ascendis.
9 Sep
Ascendis Pharma presented first infant data from its clinical trial of once-weekly TransCon CNP (Navepegritide) at ESPE 2026. Initial infant trial data for Navepegritide signals pipeline progress that may affect Ascendis' product development outlook.
4 Sep
Ascendis Pharma secures reimbursement approval, refocusing attention on its fair value narrative and potential market performance. Reimbursement approval improves product access and supports stronger revenue trajectory for Ascendis Pharma.
BioMarin secured 20% U.S. royalties on Yuviwel, prompting questions on whether monetizing a rival outperforms blocking it, with direct revenue implications for Ascendis Pharma as the product's developer. Royalties on Yuviwel directly reduce Ascendis net product revenue and margins.
Ascendis Pharma settles patent dispute and secures Canadian reimbursement approval for Yorvipath. Patent settlement removes litigation risk while Canadian reimbursement opens new revenue stream for Yorvipath.
3 Sep
BioMarin converted a competitive threat linked to Ascendis Pharma into a royalty-bearing asset. BioMarin royalty structure may moderately affect Ascendis competitive positioning and market dynamics.
31 Aug
Biomarin and Ascendis Pharma reached a mutually beneficial agreement ending all global patent disputes. Ending patent disputes removes legal risks and frees Ascendis resources for pipeline advancement.
ASND and BMRN stocks rose as analysts called patent peace a clean overhang lift, though ratings stayed unchanged. Patent resolution lifts overhang and lifts stocks for ASND but leaves analyst ratings unchanged.
Ascendis Pharma and BioMarin have entered a binding term sheet for a global settlement and license agreement related to YUVIWEL (Navepegritide). Settlement and license terms may moderately stabilize Ascendis operations and product positioning without fundamentally altering long-term trajectory.
25 Aug
Ascendis Pharma will deliver an oral presentation of week 104 data from the pivotal trial of TransCon CNP (Navepegritide) at ISDS 2026. Long-term pivotal data presentation for lead pipeline asset may moderately shift sentiment around future approval prospects.
21 Aug
Ascendis Pharma is advancing three new drugs that position the company for accelerated growth in biotechnology. Three new drug developments signal major strategic progress likely to boost long-term performance and investor outlook.
20 Aug
Ascendis Pharma A/S (ASND) released its Q2 2026 earnings call transcript detailing financial results and business updates. Q2 2026 earnings and forward outlook can significantly shift investor views and company trajectory.
Ascendis Pharma reported earnings and clinical trial updates, with analysis questioning if the stock price fully reflects these developments. Earnings results and trial updates directly affect revenue forecasts and valuation for Ascendis Pharma.
14 Aug
Ascendis Pharma reports solid Yorvipath quarter performance while Yuviwel launches with strong initial uptake, according to RBC. Solid product sales and launch momentum for Yorvipath and Yuviwel signal meaningful revenue growth and market traction for Ascendis.
13 Aug
Ascendis Pharma AS doubled revenue to EUR315 million in Q2 2026 amid continued product development progress. Doubled revenue reflects strong commercial traction that can materially lift valuation and growth outlook.
Ascendis Pharma A/S held its Q2 earnings call, covering financial results, pipeline progress, revenue figures, and strategic outlook for the biotech company. Quarterly earnings updates typically provide financial and pipeline details that moderately influence near-term stock sentiment and valuation.
Ascendis Pharma A/S reported its second quarter 2026 financial results. Quarterly financial results provide data that can shift valuation and near-term investor sentiment.
6 Aug
Ascendis Pharma A/S reports COACH Week 78 results and updates on achondroplasia programs plus YUVIWEL uptake in the U.S. Clinical data releases and product uptake updates signal major advancements in achondroplasia treatment and revenue potential.
14 Jul
FDA accepts BioMarin’s sNDA seeking full approval for Voxzogo. Competitor BioMarin’s potential full Voxzogo approval directly challenges Ascendis’ achondroplasia franchise.
12 Jul
Ascendis Pharma (ASND) reported two-year YUVIWEL trial data in achondroplasia. Two-year achondroplasia trial data can drive major regulatory and commercial shifts for Ascendis Pharma's key asset.
30 Jun
Ascendis Pharma's TransCon CNP treatment for children with achondroplasia demonstrated continued improvements in lower extremity alignment at week 104 in the pivotal ApproaCH trial. Long-term positive ApproaCH trial data bolsters TransCon CNP efficacy and Ascendis regulatory and commercial outlook.
13 Jun
Ascendis Pharma's Phase 3 data show TransCon PTH replicated endogenous PTH systemic actions through week 182 in adults with hypoparathyroidism. Positive long-term Phase 3 results for TransCon PTH in hypoparathyroidism strengthen approval and commercial prospects.
11 Jun
Ascendis Pharma A/S reported TransCon PTH sustained efficacy at five years. Five-year efficacy data for TransCon PTH strengthens approval odds and commercial outlook.