stockrowIonis Pharmaceuticals, Inc.
IONS Healthcare Biotechnology
Ionis Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $943.7 million, up 33.8% from fiscal 2024.
- Revenue
- −40.7%
- EPS
- −188.5%
- Free cash flow
- +299.3%
- Total debt
- +116.0%
Quarter to June 2026, against a year earlier
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Ionis Pharmaceuticals, Inc. (IONS) Operating margin
Ionis Pharmaceuticals, Inc.'s operating margin over the twelve months to 30 June 2026 was −68.0%, down 27.6 percentage points from fiscal 2025 (−40.5%). Over the past ten years it has ranged from −69.8% (fiscal 2022) to 32.6% (fiscal 2019); the current reading is higher than 36% of that period. That is below the Biotechnology industry median of 0.00% and below the Healthcare sector median of 0.00%.
Operating margin, annual
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Annual newest first
| Period | Operating margin | Change (points) |
|---|---|---|
| FY2025 | −40.5% | 26.92 |
| FY2024 | −67.4% | (22.46) |
| FY2023 | −44.9% | 24.93 |
| FY2022 | −69.8% | (66.12) |
| FY2021 | −3.72% | 19.88 |
| FY2020 | −23.6% | (56.19) |
| FY2019 | 32.6% | 42.82 |
| FY2018 | −10.2% | (16.27) |
| FY2017 | 6.04% | 11.45 |
| FY2016 | −5.41% | 21.29 |
Quarterly newest first
| Period | Operating margin | Change (points) |
|---|---|---|
| Jun 2026 | −38.2% | 9.54 |
| Mar 2026 | −47.7% | 57.75 |
| Dec 2025 | −105.5% | (3.26) |
| Sep 2025 | −102.2% | (133.14) |
| 42 more quarters | Free account |
Against its own ten years
Operating margin against peers
| Company | Operating margin |
|---|---|
| LGND Ligand Pharmaceuticals Incorporated compare | 9.29% |
| KOD Kodiak Sciences Inc. compare | 0.00% |
| ORKA Oruka Therapeutics, Inc. compare | 0.00% |
| IMVT Immunovant, Inc. compare | 0.00% |
| BLTE Belite Bio, Inc. Sponsored ADR compare | 0.00% |
| AXSM Axsome Therapeutics, Inc. compare | −17.5% |
| IONS Ionis Pharmaceuticals, Inc. | −68.0% |
| MIRM Mirum Pharmaceuticals, Inc. compare | −133.6% |
| CGON CG Oncology, Inc. compare | −4,056.2% |
| Biotechnology industry median | 0.00% |
| Healthcare sector median | 0.00% |
| Market median | 0.00% |
What Operating margin is
EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.
EBIT ÷ Revenue
More on IONS
- Revenue
- Net income
- EPS (diluted)
- EBITDA
- Free cash flow
- Operating cash flow
- Gross margin
- Net margin
- Free cash flow margin
- P/E ratio
- P/S ratio
- P/B ratio
- Price to free cash flow
- EV/EBITDA
- EV/Sales
- EV/FCF
- Return on equity
- Return on assets
- Return on invested capital
- Debt to equity
- Current ratio
- Total debt
- Shares outstanding
- Book value per share
- Revenue growth
- Piotroski F-score
- Altman Z-score
- Beneish M-score
- The full statement