Ionis Pharmaceuticals, Inc.

IONS Healthcare Biotechnology

Ionis Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $943.7 million, up 33.8% from fiscal 2024. In the quarter to June 2026, revenue fell 40.7%, EPS fell 188.5%, free cash flow grew 299.3% and total debt rose 116.0%, each against the same quarter a year earlier. Insiders bought in the last twelve months.

42.94 1.18 −2.67%
Market cap
$7.3B
P/E
0.0×
Fwd P/E
−20.8×
Dividend yield
—
F-score
4/9
Altman Z
2.12
Beneish M
−3.13
Dividend safety
n/a
Jun '26 Mar '26 Dec '25 Sep '25 Older periods
P/E ratio
0.00 0.00 0.00 0.00

+8 more quarters

P/S ratio
15.01 11.70 13.41 10.81
P/FCF ratio
0.00 0.00 0.00 0.00
P/Operating CF
23.19 (15.62) (91.92) (79.52)
P/B ratio
29.83 25.19 25.88 16.91
EV/Sales
14.69 11.57 12.46 9.15
EV/EBITDA
0.00 0.00 0.00 0.00
EV/FCF
(22.63) (12.52) (36.11) (28.60)
Current Ratio
7.89 4.10 3.83 2.79
Net Debt/EBITDA
7.31 5.01 4.26 10.33
Debt/Equity
3.07 2.75 3.64 0.96
Earnings Yield
(4.36%) (2.65%) (2.98%) (2.46%)
Free Cash Flow Yield
(4.33%) (7.90%) (2.57%) (2.96%)
Free Cash Flow per Share
3.31 (4.95) (1.00) (0.87)
Book value per Share
2.66 2.98 3.06 3.87
Free Cash Flow
547.30 (816.07) (160.37) (138.37)
EV/EBIT
0.00 0.00 0.00 0.00
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