stockrowIonis Pharmaceuticals, Inc.
IONS Healthcare Biotechnology
Ionis Pharmaceuticals, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $943.7 million, up 33.8% from fiscal 2024.
- Revenue
- −40.7%
- EPS
- −188.5%
- Free cash flow
- +299.3%
- Total debt
- +116.0%
Quarter to June 2026, against a year earlier
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Ionis Pharmaceuticals, Inc. (IONS) EV/EBITDA
Ionis Pharmaceuticals, Inc. has no meaningful EV/EBITDA: its trailing twelve-month EBITDA is negative. Over the past ten years it has ranged from 0.0× (November 2026) to 774× (June 2015) — the current reading is the lowest in ten years.
EV/EBITDA, daily
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Annual newest first
| Period | EV/EBITDA | Change |
|---|---|---|
| FY2025 | 0.0× | — |
| FY2024 | 0.0× | — |
| FY2023 | 0.0× | — |
| FY2022 | 0.0× | — |
| FY2021 | 281× | — |
| FY2020 | 0.0× | — |
| FY2019 | 17.9× | — |
| FY2018 | 0.0× | — |
| FY2017 | 69.1× | (65.92%) |
| FY2016 | 203× | — |
Quarterly newest first
| Period | EV/EBITDA | Change |
|---|---|---|
| Jun 2026 | 0.0× | — |
| Mar 2026 | 0.0× | — |
| Dec 2025 | 0.0× | — |
| Sep 2025 | 0.0× | — |
| 42 more quarters | Free account |
Against its own ten years
EV/EBITDA against peers
| Company | EV/EBITDA |
|---|---|
| BLTE Belite Bio, Inc. Sponsored ADR compare | n/m |
| MIRM Mirum Pharmaceuticals, Inc. compare | n/m |
| CGON CG Oncology, Inc. compare | n/m |
| IMVT Immunovant, Inc. compare | n/m |
| AXSM Axsome Therapeutics, Inc. compare | n/m |
| IONS Ionis Pharmaceuticals, Inc. | n/m |
| ORKA Oruka Therapeutics, Inc. compare | n/m |
| KOD Kodiak Sciences Inc. compare | n/m |
| LGND Ligand Pharmaceuticals Incorporated compare | 109× |
| Biotechnology industry median | 0.7× |
| Healthcare sector median | 8.4× |
| Market median | 10.9× |
What EV/EBITDA is
Enterprise Value over EBITDA tells an investor how the market values a whole company, with debt added and cash taken off, against its operating earnings.
((Stock Price × Shares (Basic, Weighted) (latest quarter)) + (Long Term Debt (Total) (latest quarter) + Current Part of Debt (latest quarter)) − Cash & Short Term Investments (latest quarter)) ÷ EBITDA (TTM)
More on IONS
- Revenue
- Net income
- EPS (diluted)
- EBITDA
- Free cash flow
- Operating cash flow
- Gross margin
- Operating margin
- Net margin
- Free cash flow margin
- P/E ratio
- P/S ratio
- P/B ratio
- Price to free cash flow
- EV/Sales
- EV/FCF
- Return on equity
- Return on assets
- Return on invested capital
- Debt to equity
- Current ratio
- Total debt
- Shares outstanding
- Book value per share
- Revenue growth
- Piotroski F-score
- Altman Z-score
- Beneish M-score
- The full statement