Xeris Biopharma Holdings, Inc.

XERS Healthcare Drug Manufacturers Specialty & Generic

Xeris Biopharma Holdings, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $291.8 million, up 43.7% from fiscal 2024.

Revenue
+44.2%
EPS
+1,479.0%
Free cash flow
+93.2%
Total debt
−13.6%

Quarter to September 2026, against a year earlier

15.16 2.08 +15.90%
Market cap
$2.4B
P/E
0.0×
Fwd P/E
−143×
Dividend yield
—
F-score
8/9
Altman Z
0.98
Beneish M
−2.58
Dividend safety
n/a

Xeris Biopharma Holdings, Inc. (XERS) Operating margin

Alert me on Operating margin

Xeris Biopharma Holdings, Inc.'s operating margin over the twelve months to 30 September 2026 was 12.7%, up 4.2 percentage points from fiscal 2025 (8.53%). Over the past ten years it has ranged from −4,496.0% (fiscal 2019) to 8.53% (fiscal 2025) — the current reading is the highest in ten years. That is above the Drug Manufacturers Specialty & Generic industry median of 0.00% and above the Healthcare sector median of 0.00%.

Operating margin, annual

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Annual newest first

Period Operating margin Change (points)
FY2025 8.53% 25.10
FY2024 −16.6% 10.28
FY2023 −26.9% 47.47
FY2022 −74.3% 157.90
FY2021 −232.2% 176.62
FY2020 −408.8% 4,087.12
FY2019 −4,496.0% (2,046.76)
FY2018 −2,449.2% (737.82)
FY2017 −1,711.4% (480.59)
FY2016 −1,230.8% —

Quarterly newest first

Period Operating margin Change (points)
Sep 2026 15.8% 10.16
Jun 2026 5.62% (3.90)
Mar 2026 9.52% (10.03)
Dec 2025 19.6% 10.50
33 more quarters

Against its own ten years

Low −4,496.0% High 8.53%
Ten-year median −320.5%
Current reading's percentile 100

Operating margin against peers

Company Operating margin
PBH Prestige Consumer Healthcare Inc. compare 25.0%
XERS Xeris Biopharma Holdings, Inc. 12.7%
AMLX Amylyx Pharmaceuticals, Inc. compare 0.00%
HCM HUTCHMED (China) Limited Sponsored ADR compare 0.00%
TRLV Trulieve Cannabis Corp. compare 0.00%
BCRX BioCryst Pharmaceuticals, Inc. compare −30.1%
PRGO Perrigo Company plc compare −39.4%
ALVO Alvotech compare −42.4%
RGC Regencell Bioscience Holdings Limited compare —
Drug Manufacturers Specialty & Generic industry median 0.00%
Healthcare sector median 0.00%
Market median 0.00%

What Operating margin is

EBIT Margin tells an investor how much operating profit, before interest and taxes, a company keeps from each unit of revenue.

EBIT ÷ Revenue

The full definition of Operating margin →

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