Taysha Gene Therapies, Inc. TSHA

4.67 (0.12) (2.51%) as of 25 Sep
Market cap
$1.6B
P/E
0.0×

Insider Decisions

Total sells 6.66
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — —
Sell — 1 — 4 1 — 1 — — 1 — —
Insider Ownership 25.65%

Capital & Financial Ratios

Market Cap 1,560.00
Revenue 11.80
Net Income (149.63)
Free Cash Flow (139.07)
Net Debt (406.15)
Current Ratio 17.76
Debt/Equity 0.13
P/E ratio 0.00
P/S ratio 146.12
P/B ratio 4.45
Past 5Y EPS Growth (63.99%)
This Y EPS Growth (46.61%)
Next Y EPS Growth (5.03%)
Next 5Y EPS Growth 10.86%
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2023 Powerpack
2022 Powerpack
2021 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 144 139 320 455
Receivables — — — —
Inventory — — — —
Other 2 — — —
150 142 325 461
2023 2024 2025 Q'26
Payables 6 4 6 9
ST’ Debt — — — —
Other — — — —
37 26 27 26
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — 57.49%
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — (0.35%) 538.42%

Revenue

Mar Jun Sep Dec Year
’26 — — — — —
’25 2 2 — 5 10
’24 3 1 2 2 8
’23 5 2 5 4 15
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (41) (40) — — —
’25 (22) (20) (24) (27) (93)
’24 (20) (22) (22) (18) (81)
’23 (20) (19) (18) (16) (73)
’22 (41) (33) (29) 15 (88)
’21 (22) (23) (32) (40) (117)
’20 (2) (2) (7) (20) (31)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (44) (40) — — —
’25 (22) (20) (24) (27) (94)
’24 (20) (22) (22) (18) (82)
’23 (24) (19) (21) (16) (80)
’22 (52) (41) (32) 12 (113)
’21 (23) (31) (36) (49) (139)
’20 (2) (5) (7) (26) (40)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (0.12) (0.13) — — —
’25 (0.08) (0.09) (0.09) (0.08) (0.34)
’24 (0.10) (0.09) (0.10) (0.07) (0.36)
’23 (0.28) (0.38) (0.93) 0.92 (0.96)
’22 (1.31) (0.84) (0.64) (0.99) (3.78)
’21 (0.87) (1.09) (1.35) (1.32) (4.64)
’20 (0.50) (1.95) (1.28) 0.33 (3.40)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.1
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — — 18.16 11.12 1.35 0.50 1.19 1.05

Analyst estimates 2026–2028

Powerpack
Low Price
— — — — 29.96 33.35 12.17 3.89 4.32 6.02
High Price
— — — 10 38 178 65 52 73 99
Employees
— — — 0 0 0 0 0 0 0
Revenue/Emp
— — — — — — 3 15 8 10
Revenue
— — — — 0.00% 0.00% 100.00% 100.00% 100.00% 100.00%
Gross Margin
— — — 0 (60) (175) (166) (112) (89) (109)
EBT
— — — 0.00% 0.00% 0.00% (6,635.25%) (722.06%) (1,071.62%) (1,115.27%)
EBT Margin
— 0 — 0 (60) (175) (166) (112) (89) (109)
Net Income
— — — 0 0 0 1 1 1 1
Depreciation
— — — 0.00 0.00 0.00 0.06 0.13 0.03 0.03
Revenue/Sh
— — — (0.03) (3.40) (4.64) (3.78) (0.96) (0.36) (0.34)
Earnings/Sh
— — — 0.00 (1.74) (3.11) (2.01) (0.63) (0.32) (0.29)
Cash Flow/Sh
— — — 0.00 (0.51) (0.57) (0.57) (0.06) 0.00 0.00
Capex/Sh
— — — 0.00 (2.25) (3.68) (2.58) (0.69) (0.33) (0.29)
Free CF/Sh
— — — 0.00 14.23 2.53 0.02 0.65 0.29 0.77
Book Value/Sh
— — — 37 18 38 44 116 250 320
Shares
— — — — — — 0.00 0.00 0.00 0.00
PE Ratio
— — — — — — 0.00 12.85 51.93 149.08
PS Ratio
— — — — — — 101.89 2.65 6.05 7.12
PB Ratio
— — — — — — 0.00 6.13 40.46 126.18
EV/Sales
— — — — — — (0.41) (1.16) (3.92) (15.14)
EV/FCF
— — — 0 (31) (117) (88) (73) (81) (93)
Op' Cash Flow
— — — 0 (9) (22) (25) (7) 0 (1)
Capex
— — — 0 (40) (139) (113) (80) (82) (94)
FCF
— — — 0 251 108 34 113 116 298
Working Cap'
— — — — — 37 38 41 44 50
Total Debt
— — — — (251) (112) (50) (104) (96) (270)
Net Debt
— — — 0 251 95 1 75 72 247
Sh' Equity
— — — (14,866.67%) (46.36%) (73.82%) (97.59%) (74.62%) (53.62%) (43.28%)
ROA
— — — 0.00% (54,849.49%) 0.00% 0.00% 0.00% 0.00% 0.00%
ROIC
— — — (0.89%) (47.79%) (100.68%) (344.67%) (294.04%) (121.94%) (68.45%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2025 · latest quarter Dec 2025

Taysha Gene Therapies, Inc. (TSHA) key facts

  • Taysha Gene Therapies, Inc. (TSHA) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • Taysha Gene Therapies, Inc.’s revenue for fiscal 2025 (year ended December 2025) was $9.8 million, up 17.3% from fiscal 2024.
  • As of September 25, 2026, TSHA traded at $4.67, a market capitalization of $1.6 billion.
  • Return on equity was −68.5% and debt-to-equity 0.13.

Source: company filings (standardised) and stockrow calculations.

Taysha Gene Therapies, Inc. (TSHA) Latest News

News by impact score

Fine-tune

18 Aug

4 transcript

Taysha Gene Therapies held its Q2 2026 earnings call to discuss financial results and business updates. Earnings calls deliver core financial metrics and forward guidance that often drive major shifts in biotech stock valuation and strategy perception.

13 Aug

4

Taysha Gene Therapies advances Rett syndrome trials and expands Catalent partnership, bolstering case for undervalued stock. Rett trial progress and Catalent expansion mark major steps that can shift Taysha trajectory and sentiment.

12 Aug

4 transcript

Taysha Gene Therapies Inc highlighted its Rett Syndrome program during the Q2 2026 earnings call. Rett Syndrome program updates directly affect TSHA's core pipeline progress and investor outlook.

3 transcript

Taysha Gene Therapies, Inc. released its Q2 2026 earnings call summary covering financial results, pipeline updates, and operational highlights. Quarterly earnings updates can shift near-term sentiment and highlight pipeline progress without guaranteeing major long-term trajectory changes.

11 Aug

3 transcript

Taysha Gene Therapies reported Q2 financial results and pipeline updates on its gene therapy programs for rare CNS diseases during the earnings call, including cash position and development timelines. Quarterly earnings updates and pipeline status reports typically produce moderate short-term market reactions without guaranteed long-term trajectory shifts.

3

Taysha Gene Therapies reported second quarter 2026 financial results and provided a corporate update. Quarterly financial results and corporate updates deliver moderate influence on near-term sentiment and operations.

3 Aug

4

Taysha Gene Therapies expanded its strategic partnership with Catalent to include future commercial manufacturing support for TSHA-102 gene therapy targeting Rett Syndrome. Expanded manufacturing partnership advances TSHA-102 toward commercial production and market launch for Rett Syndrome.

24 Jun

3

Taysha Gene Therapies priced a public offering of common stock and pre-funded warrants. Public stock offering raises operating capital but dilutes shareholders and pressures near-term stock price.

3

Taysha Gene Therapies announces proposed public offering of common stock and pre-funded warrants. Proposed offering enables capital raise while risking share dilution and short-term stock pressure.

22 Jun

4

Taysha Gene Therapies completes enrollment in pivotal Rett Syndrome trial. Pivotal trial enrollment completion marks major progress toward potential approval in core gene therapy program.

4

Taysha Gene Therapies completed dosing in the REVEAL pivotal trial for TSHA-102 in Rett syndrome and reported longer-term clinical data from Part A of the Phase 1/2 REVEAL trials. Pivotal trial dosing completion plus fresh Rett syndrome data for lead asset TSHA-102 marks major regulatory and clinical milestone likely to shift company trajectory and sentiment.

14 May

3

Taysha Gene Therapies (TSHA) reported financial results for Q1 2026. Q1 2026 financial results affect financial performance and investor sentiment.

11 May

3

Canaccord Genuity maintains Buy rating on Taysha Gene Therapies (TSHA) following positive Q1 highlights. Analyst's sustained Buy rating after Q1 highlights supports moderate positive influence on market sentiment and short-term performance.

7 May

4

Taysha Gene Therapies, Inc. (TSHA) Q1 2026 earnings call summary covers financial results, operational updates, pipeline progress, and forward guidance for the gene therapy developer. Q1 2026 earnings disclosure impacts TSHA's valuation through revealed financial health, clinical advancements, and strategic outlook.

4

Taysha Gene Therapies Q1 earnings call highlighted $209 million cash position providing runway into 2026, advancement of TSHA-102 for Rett syndrome with Phase 1/2 data expected mid-2024 and registrational study start H2 2024, TSHA-118 for CLN1 disease on track for IND mid-2025, and TSHA-120 for giant axonal neuropathy with positive interim data. Pipeline progress in Rett syndrome and upcoming clinical milestones position Taysha for significant clinical and market advancements.

6 May

4

Taysha Gene Therapies, Inc. (TSHA) reported first quarter 2026 financial results and provided a corporate update. Quarterly financial results and corporate updates for a gene therapy company often signal pipeline progress, cash runway, and strategic shifts that drive significant stock volatility and investor sentiment.

27 Apr

3

Taysha Gene Therapies to present new preclinical data supporting construct design of TSHA-102 for Rett Syndrome at the ASGCT 2026 Annual Meeting. New preclinical data presentation for TSHA-102 at a major conference signals progress in Rett Syndrome program and may boost sentiment but lacks clinical validation.

22 Apr

3

Taysha Gene Therapies (TSHA) stock price surges 343.45% from year-ago levels. 343.45% year-over-year stock surge boosts market sentiment and investor interest without detailing underlying catalysts.

6 Apr

4

Taysha Gene Therapies (TSHA) advances crucial gene therapy for Rett Syndrome, showing promising progress in preclinical and clinical development stages. Progress on Rett Syndrome treatment strengthens TSHA's pipeline in a high-need area, likely boosting investor sentiment and market performance.

21 Mar

4

FDA grants Breakthrough Therapy Designation to TSHA-102 for Taysha Gene Therapies (TSHA), accelerating development and review for Rett syndrome while reshaping the company's investment narrative through enhanced clinical prospects and market potential. FDA Breakthrough Therapy Designation for TSHA-102 fast-tracks regulatory review and bolsters TSHA's pipeline value, significantly impacting investor sentiment and stock trajectory.

19 Mar

4

Taysha Gene Therapies Inc (TSHA) reported a strong cash position in its Q4 2025 earnings call highlights. Strong cash position from Q4 2025 earnings bolsters financial stability and investor confidence for TSHA's future performance.

4

Taysha Gene Therapies, Inc. (TSHA) Q4 2025 earnings call summary details financial results, pipeline updates, clinical progress, and future outlook. Q4 earnings call summaries reveal financial performance, guidance, and strategic shifts that significantly influence TSHA's trajectory and investor sentiment.

4 transcript

Taysha Gene Therapies (TSHA) Q4 2025 earnings call transcript released, covering financial results, pipeline updates, and forward guidance. Q4 earnings call discloses financial performance, clinical progress, and strategic plans with potential to significantly sway TSHA's market trajectory.

4

Taysha Gene Therapies, Inc. (TSHA) reported full-year 2025 financial results and provided a corporate update. Full-year financial results and corporate update signal major strategic and operational developments pivotal to TSHA's trajectory and market performance.

3

Taysha Gene Therapies released Q4 earnings call highlights detailing financial results, pipeline advancements in gene therapies for rare diseases, clinical trial updates, cash position, and strategic outlook for 2024. Q4 earnings highlights reveal financial performance and pipeline progress with moderate influence on investor sentiment and stock trajectory.

18 Mar

3

Taysha Gene Therapies Inc (TSHA) Q4 2025 earnings report preview highlights analyst expectations for revenue growth, clinical trial updates, cash position, and pipeline advancements in gene therapies. Earnings preview for Q4 2025 may moderately affect TSHA's stock sentiment and financial outlook through anticipated clinical and financial metrics.

4 Feb

4

Taysha Gene Therapies, Inc. is experiencing shifts in its gene therapy approval path narrative due to recent milestones in its Rett syndrome trial. These developments may influence the company's strategic direction and regulatory outlook, potentially impacting its market position and investor sentiment. Recent trial milestones could significantly alter Taysha's regulatory trajectory and market dynamics.

2 Feb

4

Taysha Gene Therapies, Inc. (TSHA) has received positive feedback from Wells Fargo regarding its progress in the Rett Syndrome program. The investment firm highlighted the potential of TSHA's gene therapy approach, which aims to address the underlying causes of Rett Syndrome. This endorsement is expected to bolster investor confidence and may enhance the company's market position as it advances its clinical initiatives. Wells Fargo's support indicates significant confidence in Taysha's Rett Syndrome program, which could influence investor sentiment and the company's strategic direction.

29 Jan

4

Analysts have provided insights on Taysha Gene Therapies, Inc. (TSHA), highlighting recent developments and market expectations. The company is focused on advancing its gene therapy programs, with particular attention on its pipeline and potential partnerships. Analysts are optimistic about TSHA's future, citing the innovative nature of its therapies and the growing demand in the gene therapy sector. Market sentiment appears to be cautiously positive, with expectations for upcoming milestones to influence stock performance. Significant advancements in gene therapy programs and potential partnerships could greatly influence the company's market position and investor sentiment.

14 Jan

4

Taysha Gene Therapies, Inc. is making strides in developing a gene therapy for Rett syndrome, a rare neurological disorder. The company is advancing its lead candidate, TSHA-101, which targets the underlying genetic cause of the disease. Recent preclinical data has shown promising results, leading to increased investor interest and potential partnerships. Taysha aims to initiate clinical trials soon, which could significantly impact its market position and valuation. Advancements in TSHA-101 and upcoming clinical trials could significantly alter Taysha's market trajectory and investor sentiment.

stockrow.com/TSHA · Data as of Dec 31, 2025 · For information only; not investment advice. · © 2026 stockrow.com