Structure Therapeutics Inc. Sponsored ADR GPCR

35.93 (0.09) (0.25%) as of 25 Sep
Market cap
$2.6B
P/E
0.0×

Insider Decisions

in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — —
Sell — — — — — — — — — — — —
Insider Ownership 4.39%

Capital & Financial Ratios

Market Cap 2,590.00
Revenue —
Net Income (214.83)
Free Cash Flow (224.50)
Net Debt (1,342.66)
Current Ratio 20.75
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 0.00
P/B ratio 1.93
Past 5Y EPS Growth (51.75%)
This Y EPS Growth (108.19%)
Next Y EPS Growth (28.81%)
Next 5Y EPS Growth (25.71%)
in millions of $

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 467 884 1,446 1,343
Receivables — — 100 —
Inventory — — — —
Other — — — —
474 891 1,570 1,372
2023 2024 2025 Q'26
Payables 5 8 14 11
ST’ Debt — — — —
Other — — — —
25 36 63 66
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — —
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 111.85% 161.46%

Revenue

Year
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 15 (120) — — —
’25 (52) (55) (51) (64) (222)
’24 (34) (26) (20) (36) (117)
’23 (20) (17) (21) (22) (79)
’22 (14) (10) (10) (12) (46)
’21 — — — (32) (32)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 14 (120) — — —
’25 (53) (55) (53) (66) (226)
’24 (34) (27) (20) (36) (118)
’23 (20) (17) (21) (23) (82)
’22 (14) (10) (11) (12) (46)
’21 — — — (33) (33)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (1.05) (1.46) — — —
’25 (0.82) (1.07) (1.12) 0.63 (2.39)
’24 (0.56) (0.53) (0.59) (0.65) (2.33)
’23 (0.75) (0.61) (0.62) (0.17) (2.44)
’22 (4.33) (4.43) (3.81) (3.49) (16.06)
’21 — — — — (14.02)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.1
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — — — — — 20.80 25.90 13.22

Analyst estimates 2026–2028

Powerpack
Low Price
— — — — — — — 75.02 62.74 94.90
High Price
— — — — — 68 68 93 163 220
Employees
— — — — — 0 0 0 0 0
Revenue/Emp
— — — — — — — — — —
Revenue
— — — — 0.00% 0.00% 0.00% — — —
Gross Margin
— — — — (16) (38) (51) (89) (122) (141)
EBT
— — — — 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
EBT Margin
— — — — (16) (38) (51) (90) (123) (141)
Net Income
— — — — 0 0 (1) 0 1 2
Depreciation
— — — — 0.00 0.00 0.00 0.00 0.00 0.00
Revenue/Sh
— — — — (0.44) (14.02) (16.06) (2.44) (2.33) (2.39)
Earnings/Sh
— — — — (0.39) (11.85) (14.44) (2.16) (2.22) (3.75)
Cash Flow/Sh
— — — — 0.00 (0.44) (0.05) (0.06) (0.02) (0.06)
Capex/Sh
— — — — (0.39) (12.29) (14.48) (2.22) (2.24) (3.81)
Free CF/Sh
— — — — 0.97 37.67 26.55 12.33 16.43 25.61
Book Value/Sh
— — — — 37 3 3 37 53 59
Shares
— — — — — — — — — —
PE Ratio
— — — — — — — — — —
PS Ratio
— — — — — — — — — —
PB Ratio
— — — — — — — — — —
EV/Sales
— — — — — — — — — —
EV/FCF
— — — — (14) (32) (46) (79) (117) (222)
Op' Cash Flow
— — — — 0 (1) 0 (2) (1) (4)
Capex
— — — — (14) (33) (46) (82) (118) (226)
FCF
— — — — 35 101 80 449 855 1,507
Working Cap'
— — — — 0 1 0 — — —
Total Debt
— — — — (37) (107) (91) (467) (884) (1,446)
Net Debt
— — — — 36 102 85 453 865 1,516
Sh' Equity
— — — — 0.00% (58.41%) (50.56%) (30.91%) (17.69%) (11.35%)
ROA
— — — — 0.00% 0.00% 0.00% 0.00% 0.00% (157.24%)
ROIC
— — — — 0.00% 100.37% 58.75% (53.06%) (18.60%) (11.86%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Structure Therapeutics Inc. Sponsored ADR peers in Biotechnology

All 616 Biotechnology stocks →

Structure Therapeutics Inc. Sponsored ADR (GPCR) key facts

  • Structure Therapeutics Inc. Sponsored ADR (GPCR) is a Biotechnology company in the Healthcare sector, traded in the US as an ADR.
  • As of September 25, 2026, GPCR traded at $35.93, a market capitalization of $2.6 billion.
  • Return on equity was −11.9% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Structure Therapeutics Inc. Sponsored ADR (GPCR) Latest News

News by impact score

Fine-tune

23 Sep

3

Novo Nordisk's CHMP in Europe has recommended Frehemgo (denecimig) for hemophilia A in adults and children with or without inhibitors, and issued a positive opinion for Sogroya (somapacitan) for children with idiopathic short stature or unexplained short stature; final European Commission decision pending. Frehemgo would offer monthly, biweekly, or weekly prophylaxis via a single-use prefilled pen and could launch in select EU countries in Q4 2026, with FDA review ongoing for the same hemophilia indication. Sogroya could broaden Novo's rare endocrine franchise if approved for ISS (and potentially SGA and NS indications in the EU), potentially becoming the first EU-approved ISS growth hormone. Novo's H1 2026 Rare Disease sales were 9.1 billion DKK, aided by Sogroya growth; Etavopivat and Alhemo contribute. The piece notes rising GLP-1 competition from Lilly and flags Structure Therapeutics and Viking Therapeutics as smaller GLP-1 rivals, signaling diversification pressure. Increased GLP-1 competition from Novo and Lilly could moderately weigh on Structure Therapeutics' market position and investor sentiment, given its late-stage aleniglipron program.

22 Sep

3

Structure Therapeutics (GPCR) presented fresh data for its oral obesity pipeline, highlighting early-stage ACCG-2671 results and longer-term aleniglipron weight-loss trials to investors. Shares rose about 5.2% to $36.81 on the session, though the year-to-date drop remains around 46%. Over one year, total shareholder return stands at roughly 50.6% with a 30-day pullback of about 25%. Valuation sits at a 1.9x price-to-book, well below peers at 3.7x and the broader US pharmaceutical group at 2.4x, reflecting the lack of revenue and a net loss of $214.84 million. The article flags notable risks: disappointments in readouts or new equity raises that could dilute holdings. The takeaway is a wait-and-see stance on whether to lean into today’s reset or await a cleaner entry as the valuation story unfolds. Fresh obesity-trial data and a lower P/B valuation could modestly influence sentiment and funding dynamics, but the early-stage pipeline and dilution risks cap upside.

14 Sep

3

Morgan Stanley downgraded NVO, potentially worsening patent challenges and rival competition for Structure Therapeutics GPCR. NVO downgrade may affect GPCR competitive positioning via patent and rival dynamics but without major trajectory change.

10 Sep

3

Structure Therapeutics (GPCR) awaits repeat dosing data to confirm a 3.3% weight-loss signal from its clinical candidate. Repeat dosing results on the weight-loss signal may shift sentiment around the company's lead obesity asset.

8 Sep

4

Structure Therapeutics reports up to 16.2% weight loss in aleniglipron trial. Strong positive trial data on weight loss drug positions company competitively in obesity treatment market.

4

Structure Therapeutics reports positive clinical data across its oral small molecule amylin and GLP-1 programs for chronic weight management. Positive clinical data on amylin and GLP-1 programs signals major pipeline progress and competitive positioning in obesity treatment.

17 Aug

3

Eli Lilly shares rose around 6% after strong Q2 results, with analysis on whether to buy, sell or hold the stock. Eli Lilly's robust Q2 performance signals sustained GLP-1 market dominance that can pressure competitors including Structure Therapeutics.

13 Aug

4

Eli Lilly's Foundayo oral GLP-1 drug recorded $98M in Q2 sales, prompting questions on its future development and market path. Lilly's Foundayo Q2 sales underscore intensifying competition in oral GLP-1 space directly affecting GPCR's positioning.

6 Aug

3

Structure Therapeutics Inc. Sponsored ADR (GPCR) reported second quarter 2026 financial results and recent highlights. Quarterly financial results and highlights supply performance data that can shift near-term investor sentiment and valuation.

3 Aug

3

Novo Nordisk approaches Q2 earnings with investor guidance focused on positioning in the stock amid ongoing obesity drug market dynamics. Novo Nordisk Q2 results and outlook may shift sentiment across GLP-1 competitors including Structure Therapeutics.

23 Jul

3

Eli Lilly's GLP-1 portfolio sales growth is positioned to shape competitive dynamics and market expectations ahead of Structure Therapeutics' Q2 results in the obesity and diabetes treatment space. Lilly GLP-1 performance data sets broader market benchmarks that may moderately shift sentiment and positioning for GPCR without directly altering its core pipeline trajectory.

18 Jun

3

Novo Nordisk seeks to expand Wegovy pill access in Europe to offset mounting pressures, with implications for competitors including Structure Therapeutics. NVO's European Wegovy push increases competitive pressure on GPCR in the oral GLP-1 space.

7 Jun

4

Structure Therapeutics (GPCR) reports positive Phase 2 weight loss data for Aleniglipron. Positive Phase 2 data for lead obesity candidate Aleniglipron materially improves clinical prospects and investor sentiment.

4

Phase 2b oral GLP-1 data on Aleniglipron prompts reassessment of the bull case for Structure Therapeutics (GPCR). Phase 2b results for lead candidate Aleniglipron directly affect GPCR's clinical trajectory and investor sentiment.

5 Jun

4

Structure Therapeutics published Phase 2b ACCESS program results for aleniglipron in Nature Medicine, detailing efficacy and safety data for obesity treatment. Peer-reviewed Phase 2b publication in Nature Medicine strengthens clinical validation of lead obesity asset and supports pipeline advancement.

24 May

3

Structure Therapeutics Inc. Sponsored ADR (GPCR) shares rose 60% after a top healthcare fund acquired an additional $11 million stake. Fund purchase adds institutional buying interest that may lift short-term sentiment without shifting company fundamentals.

21 May

4

Eli Lilly's triple-acting obesity drug met its primary goal in a Phase 3 trial. Eli Lilly's Phase 3 success strengthens competition against Structure Therapeutics' obesity drug candidate and pressures GPCR's market prospects.

17 May

4

Structure Therapeutics GPCR stock surged 60% as Phase 3 plans advance for its obesity drug. A fund sold $4.7 million in shares. Phase 3 advancement for obesity drug marks major clinical progress that can significantly alter trajectory and sentiment despite recent fund sale.

7 May

4

Structure Therapeutics Inc. (GPCR) reported first-quarter 2026 financial results, including cash position, R&D expenses, and G&A costs, alongside highlights such as progress in GSBR-1290 Phase 2b trial for obesity, upcoming data readouts, and pipeline advancements. Quarterly earnings with clinical trial updates signal key pipeline progress, potentially driving major shifts in investor sentiment and valuation.

3 May

4

Structure Therapeutics (GPCR) shares dropped 7.2% despite strong Phase 2 data for oral GLP-1 agonist GSBR-1290 showing significant weight loss and plans for FDA end-of-Phase 2 meeting, with the decline attributed to profit-taking after recent rally and high expectations in competitive GLP-1 market. Strong Phase 2 oral GLP-1 data and FDA plans represent a major clinical milestone boosting long-term prospects in the high-stakes obesity drug sector.

29 Apr

3

Structure Therapeutics (GPCR) positioned as a top biotech investment due to strong pipeline, including oral GLP-1 drug GSBR-1290 advancing in Phase 2b trials with promising weight loss data, robust cash position, and attractive valuation. Endorsement as top biotech highlights promising GLP-1 candidate and financial strength, potentially lifting sentiment but limited by ongoing trial risks.

27 Apr

4

Structure Therapeutics will present data on its oral GLP-1 receptor agonist aleniglipron, amylin analog, and their combination at the American Diabetes Association's 86th Scientific Sessions. Upcoming data presentations on key obesity and diabetes candidates at a major conference signal potential breakthroughs that could drive substantial stock gains and reshape competitive positioning.

17 Apr

4

Eli Lilly's oral GLP-1 pill Foundayo demonstrated heart benefits in a diabetes study. Lilly's positive data on its oral GLP-1 drug intensifies competition against Structure Therapeutics' similar pipeline candidate.

6 Apr

4

Eli Lilly's oral obesity pill Foundayo approved, prompting investment strategies for Lilly stock amid competition from Structure Therapeutics (GPCR) developing similar therapies. Lilly Foundayo approval validates oral obesity drug market but intensifies competition, significantly pressuring GPCR's trajectory and investor sentiment.

29 Mar

4

Structure Therapeutics Inc. (GPCR) announces positive Phase 2 obesity trial data, accelerating shift to Phase 3 development amid heightened investor focus. Phase 2 obesity data success propels Phase 3 trials, marking a pivotal clinical milestone that could drive substantial stock gains and competitive positioning.

19 Mar

4

Eli Lilly confirms its next-generation obesity drug delivers superior weight loss compared to current treatments, highlighting strong phase 2 data in the competitive GLP-1 market. Eli Lilly's confirmation of superior weight loss in its next-gen obesity drug heightens competition and raises performance benchmarks for Structure Therapeutics' oral GLP-1 candidates.

3

Eli Lilly's experimental drug retatrutide achieved up to 24% weight loss in late-stage trials, positioning it as a potent contender in the obesity treatment market. Retatrutide's strong phase 3 results validate the obesity drug market but heighten competitive pressure on Structure Therapeutics' pipeline.

18 Mar

5

Structure Therapeutics' oral GLP-1 drug aleniglipron achieved over 15% placebo-adjusted weight loss at 12 weeks in the Phase II ACCESS II trial, with strong tolerability and plans to advance to Phase III. Over 15% weight loss in Phase II for oral GLP-1 aleniglipron positions Structure Therapeutics as a leader in the booming obesity market, potentially transforming its valuation and competitive standing.

17 Mar

4

Structure Therapeutics' (GPCR) oral GLP-1 drug matches Wegovy's weight loss in phase 2a trial data, intensifying competition for Novo Nordisk's dominance. Positive clinical data matching Wegovy's efficacy strengthens GPCR's competitive positioning and investor sentiment in the GLP-1 market.

16 Mar

3

Structure Therapeutics' ADR (GPCR) stock surges amid excitement over its obesity drug candidate GSBR-1290, but analysts question its ability to compete with Eli Lilly's upcoming oral weight-loss pill orforglipron. Stock pop signals market enthusiasm for GPCR's obesity drug but highlights competitive risks from Lilly's advanced candidate.

stockrow.com/GPCR · For information only; not investment advice. · © 2026 stockrow.com