Sionna Therapeutics, Inc.

SION Healthcare Biotechnology

In the quarter to June 2026, EPS fell 61.0% and free cash flow fell 22.4%, each against the same quarter a year earlier.

3.89 0.19 −4.66%
Market cap
$184.5M
P/E
0.0×
Fwd P/E
—
Dividend yield
—
F-score
n/a
Altman Z
n/a
Beneish M
n/a
Dividend safety
n/a

Insider Decisions trades per month

Total sells 151.09
Totals in millions of $.
Dec 25 Mar 26 Jun 26 Sep 26
Buy — — — — — — — — — — — —
Sell 4 5 1 2 1 4 4 2 3 — 1 —
Insider Ownership 47.82%

Capital & Financial Ratios $m

Market Cap 184.47
Revenue —
Net Income (97.38)
Free Cash Flow (75.92)
Net Debt (211.03)
Current Ratio 20.05 (at or above 1.5: strong)
Debt/Equity 0.00 (at or below 0.5: strong)
P/E ratio 0.00
Fwd P/E —
P/S ratio 0.00
P/B ratio 0.66
Past 5Y EPS Growth —
This Y EPS Growth (31.87%) (below 0%: weak)
Next Y EPS Growth 7.52%
Next Y revenue growth —
Next 5Y EPS Growth (11.40%) (below 0%: weak)

Green and red mark values outside typical ranges. How we judge →

Valuation vs history

Dividends

Payout Ratio —
Annual Dividend Rate —
Annual Dividend Yield —

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 39 148 236 211
Receivables — — — —
Inventory — — — —
Other — — — —
39 151 241 216
2023 2024 2025 Q'26
Payables 1 1 1 1
ST’ Debt — — — —
Other — — 0 0
8 10 12 11

Compound Annual Growth %

10y 5y 3y
Sales — — —
Cash Flow — — —
Earnings — — —
Book Value — — —

Revenue $m

Year
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (22) (22) — — —
’25 (16) (18) (15) (17) (66)
’24 (13) (10) (18) (12) (53)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (22) (22) — — —
’25 (16) (18) (15) (17) (67)
’24 (13) (10) (18) (12) (53)
Fiscal quarters ending in the months shown.

EPS $

Mar Jun Sep Dec Year
’26 (0.60) (0.66) — — —
’25 (0.62) (0.41) (0.46) (0.46) (1.88)
’24 (3.84) (2.71) (5.67) (3.38) (15.99)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

2.8
1Buy 2 3Hold 4 5Sell

Ten years at a glance

Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 Trend 2026e 2027e 2028e
Price, $
Price, $ Low — — — — — — — — — 7.26

Analyst estimates 2026–2028

Powerpack
High — — — — — — — — — 45.00
People
People Employees — — — — — — — 35 41 59
Revenue/emp, $m — — — — — — — 0.00 0.00 0.00
Income, $m
Income, $m Revenue — — — — — — — — — —
Gross margin, % — — — — — — — — — —
EBT — — — — — — — (47) (62) (75)
EBT margin, % — — — — — — — 0.00 0.00 0.00
Net income — — — — — — — (47) (62) (75)
Depreciation — — — — — — — 0 (2) (2)
Per share, $
Per share, $ Revenue — — — — — — — 0.00 0.00 0.00
Earnings — — — — — — — (16.11) (15.99) (1.88)
Cash flow — — — — — — — (14.90) (13.68) (1.66)
Capex — — — — — — — (0.38) (0.01) (0.01)
Free cash flow — — — — — — — (15.28) (13.69) (1.67)
Book value — — — — — — — (39.17) (42.42) 7.68
Shares, m — — — — — — — 3 4 40
Valuation, ×
Valuation, × P/E — — — — — — — — — —
P/S — — — — — — — — — —
P/B — — — — — — — — — —
EV/Sales — — — — — — — — — —
EV/FCF — — — — — — — — — —
Cash, $m
Cash, $m Operating cash flow — — — — — — — (44) (53) (66)
Capex — — — — — — — (1) 0 0
Free cash flow — — — — — — — (45) (53) (67)
Balance, $m
Balance, $m Working capital — — — — — — — 31 141 230
Total debt — — — — — — — — — —
Net debt — — — — — — — (39) (148) (236)
Shareholders’ equity — — — — — — — (115) (164) 307
Returns, %
Returns, % ROA — — — — — — — 0.00 (51.90) (29.42)
ROIC — — — — — — — 0.00 0.00 (78.38)
ROE — — — — — — — 0.00 44.29 (105.18)
Negative figures in brackets.

All 10 years →

Charts ten years each

Sionna Therapeutics, Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
ADCT ADC Therapeutics SA $190.2M — (loss-making) — (loss-making) +2.17% (above 0%: growing) n/m +50.98% (above 0%: growing) 87.80% (132.03%) Compare
STRO Sutro Biopharma, Inc. $190.0M — (loss-making) — (loss-making) −84.57% (below 0%: shrinking) n/m +14.55% (above 0%: growing) 100.00% (303.77%) Compare
YARW Yarrow Bioscience, Inc $188.8M — (loss-making) — (loss-making) +40.58% (above 0%: growing) n/m +81.56% (above 0%: growing) 100.00% (3,197.94%) Compare
TRDA Entrada Therapeutics, Inc. $186.1M — (loss-making) — (loss-making) −53.95% (below 0%: shrinking) n/m −9.10% (below 0%: shrinking) 100.00% (5,007.02%) Compare
UPB Upstream Bio, Inc. $184.6M — (loss-making) — (loss-making) −17.50% (below 0%: shrinking) n/m +9.33% (above 0%: growing) 100.00% (5,480.98%) Compare
SION Sionna Therapeutics, Inc. $184.5M — (loss-making) — — n/m −22.40% (below 0%: shrinking) — 0.00%
ELDN Eledon Pharmaceuticals, Inc. $184.5M — (loss-making) — — n/m −28.02% (below 0%: shrinking) 0.00% 0.00% Compare
ACOG Alpha Cognition Inc. $184.0M — (loss-making) — +267.56% (above 0%: growing) n/m −109.25% (below 0%: shrinking) 94.80% (127.29%) Compare
BCYC Bicycle Therapeutics PLC Sponsored ADR $181.4M — (loss-making) — (loss-making) −78.46% (below 0%: shrinking) n/m +31.95% (above 0%: growing) 100.00% (8,673.93%) Compare
Median of peers $185.4M — — −17.50% — +11.94% 100.00% (1,750.85%)

All 614 Biotechnology stocks →

Sionna Therapeutics, Inc. (SION) key facts

  • Sionna Therapeutics, Inc. (SION) is a Biotechnology company in the Healthcare sector, listed on Nasdaq.
  • As of October 16, 2026, SION traded at $3.89, a market capitalization of $184.5 million.
  • Return on equity was −105.2% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Sionna Therapeutics, Inc. (SION) Latest News

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