Bicycle Therapeutics PLC Sponsored ADR BCYC

3.69 (0.04) (1.07%) as of 25 Sep
Market cap
$199.4M
P/E
0.0×
Growth Flags show if company had growth for consecutive years

Insider Decisions

Total sells 0.55
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — — — — — — — — — — —
Sell 7 — — 6 — — 5 — — 5 — —
Insider Ownership 34.96%

Capital & Financial Ratios

Market Cap 199.41
Revenue 61.21
Net Income (190.41)
Free Cash Flow (208.28)
Net Debt (510.05)
Current Ratio 12.08
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 4.21
P/B ratio 0.50
Past 5Y EPS Growth (0.87%)
This Y EPS Growth 23.13%
Next Y EPS Growth 4.49%
Next 5Y EPS Growth 6.86%
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2023 Powerpack
2022 Powerpack
2021 Powerpack
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 526 880 628 510
Receivables 24 36 36 47
Inventory — — — —
Other — — — —
562 929 683 575
2023 2024 2025 Q'26
Payables 13 16 10 6
ST’ Debt — — — —
Other — — — —
70 67 57 48
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — 47.52% 71.21%
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 44.91% 31.09%

Revenue

Mar Jun Sep Dec Year
’26 1 1 — — —
’25 10 3 12 48 73
’24 20 9 3 4 35
’23 5 11 5 5 27
’22 4 4 3 3 14
’21 2 2 4 4 12
’20 1 2 4 4 10
in millions of $ · fiscal quarters ending in the months shown

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (66) (50) — — —
’25 (86) (73) (71) (19) (250)
’24 (71) (45) (40) (9) (165)
’23 (46) 34 (1) (47) (61)
’22 (26) (24) (6) (30) (86)
’21 (14) (12) 22 (10) (15)
’20 21 (12) (10) (17) (18)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (67) (50) — — —
’25 (87) (73) (72) (20) (252)
’24 (71) (45) (40) (10) (166)
’23 (49) 34 (2) (47) (64)
’22 (31) (33) (9) (32) (105)
’21 (14) (13) 22 (12) (17)
’20 21 (13) (10) (17) (19)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (0.87) (0.72) — — —
’25 (0.88) (1.14) (0.85) (0.29) (3.16)
’24 (0.62) (0.77) (0.74) (0.75) (2.90)
’23 (1.30) (1.41) (1.26) (1.16) (5.08)
’22 (0.93) (0.90) (0.96) (1.01) (3.80)
’21 (0.73) (0.74) (0.59) (0.63) (2.67)
’20 (0.63) (0.67) (0.52) (0.83) (2.66)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.6
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — 6.24 9.16 18.00 12.08 12.54 12.17 6.03

Analyst estimates 2026–2028

Powerpack
Low Price
— — — 14.91 22.71 62.08 60.80 31.91 28.67 15.47
High Price
— — 61 72 87 119 236 284 305 288
Employees
— 0 0 0 0 0 0 0 0 0
Revenue/Emp
— 2 7 14 10 12 14 27 35 73
Revenue
0.00% 100.00% 100.00% 100.00% 100.00% 100.00% 100.00% 100.00% 100.00% 100.00%
Gross Margin
(14) (16) (22) (31) (52) (68) (114) (179) (174) (219)
EBT
0.00% (790.39%) (311.69%) (223.62%) (497.92%) (585.47%) (789.88%) (664.32%) (492.69%) (301.45%)
EBT Margin
(14) (16) (22) (31) (51) (67) (113) (181) (169) (219)
Net Income
0 0 1 1 1 1 4 7 7 6
Depreciation
0.00 6.18 16.26 1.25 0.54 0.47 0.49 0.76 0.61 1.05
Revenue/Sh
(0.76) (48.81) (49.78) (2.77) (2.66) (2.67) (3.80) (5.08) (2.90) (3.16)
Earnings/Sh
(0.54) (4.25) (59.42) (2.59) (0.93) (0.59) (2.90) (1.70) (2.83) (3.60)
Cash Flow/Sh
0.00 (3.34) (2.70) (0.14) (0.06) (0.08) (0.64) (0.08) (0.02) (0.03)
Capex/Sh
(0.54) (7.59) (62.12) (2.73) (0.99) (0.67) (3.54) (1.79) (2.85) (3.64)
Free CF/Sh
0.38 (141.65) (159.09) 8.44 4.99 13.82 9.13 10.42 13.62 8.80
Book Value/Sh
21 0 0 11 19 25 30 36 58 69
Shares
— 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00 0.00
PE Ratio
— 0.93 0.93 7.55 33.08 130.42 61.52 24.33 23.10 6.76
PS Ratio
— 0.00 0.00 1.12 3.60 4.41 3.29 1.77 1.03 0.80
PB Ratio
— (4.61) (4.61) 1.01 21.47 95.67 40.39 6.13 (1.30) (1.61)
EV/Sales
— 1.95 1.95 (0.46) (11.75) (66.52) (5.56) (2.60) 0.28 0.46
EV/FCF
(11) (1) (26) (29) (18) (15) (86) (61) (165) (250)
Op' Cash Flow
0 (1) (1) (2) (1) (2) (19) (3) (1) (2)
Capex
(11) (3) (27) (30) (19) (17) (105) (64) (166) (252)
FCF
7 62 68 95 133 422 316 492 861 626
Working Cap'
— — — 1 15 30 30 31 — —
Total Debt
(9) (68) (63) (91) (121) (409) (309) (496) (880) (628)
Net Debt
8 (47) (70) 93 95 346 271 371 793 610
Sh' Equity
(31.48%) (37.88%) (28.07%) (31.91%) (37.60%) (20.85%) (25.32%) (35.92%) (21.78%) (26.15%)
ROA
0.00% 0.00% 0.00% (704.84%) 0.00% 0.00% 0.00% 0.00% 0.00% 0.00%
ROIC
33.37% 40.16% 37.34% (261.92%) (54.08%) (30.25%) (36.53%) (56.31%) (29.04%) (31.21%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2025 · latest quarter Jun 2026

Bicycle Therapeutics PLC Sponsored ADR peers in Biotechnology

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Bicycle Therapeutics PLC Sponsored ADR (BCYC) key facts

  • Bicycle Therapeutics PLC Sponsored ADR (BCYC) is a Biotechnology company in the Healthcare sector, traded in the US as an ADR.
  • Bicycle Therapeutics PLC Sponsored ADR’s revenue for fiscal 2025 (year ended December 2025) was $72.6 million, up 105.8% from fiscal 2024.
  • As of September 25, 2026, BCYC traded at $3.69, a market capitalization of $199.4 million.
  • Return on equity was −31.2% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Bicycle Therapeutics PLC Sponsored ADR (BCYC) Latest News

News by impact score

Fine-tune

30 Jul

3

Bicycle Therapeutics reported recent business progress and second quarter 2026 financial results. Standard quarterly results and business updates typically produce moderate effects on valuation and sentiment without major strategic shifts.

21 May

3

Bicycle Therapeutics will present initial Duravelo-2 trial data at the 2026 ASCO Annual Meeting. Anticipation of Duravelo-2 clinical data at a major oncology conference may moderately shift investor sentiment around pipeline progress.

30 Apr

4

Bicycle Therapeutics PLC (BCYC) reported recent business progress and first quarter 2026 financial results. Quarterly financial results combined with business progress updates signal potential pipeline advancements and financial health shifts that significantly affect investor sentiment and stock trajectory.

21 Apr

4

Bicycle Therapeutics announces oral and poster presentations at the 2026 ASCO Annual Meeting. Oral presentations at ASCO signal advanced clinical data progress, likely driving significant investor sentiment and stock trajectory shifts.

20 Apr

4

Bicycle Therapeutics presented updates on Nuzefatide Pevedotin and EphA2 pipeline programs at the AACR Annual Meeting 2026. Pipeline updates at a major oncology conference like AACR highlight potential clinical progress that can significantly influence BCYC's valuation and investor sentiment.

17 Apr

4

Morgan Stanley updated its outlook for Bicycle Therapeutics plc (BCYC) amid the company's pipeline refocus. Pipeline refocus signals a major strategic shift that could significantly alter BCYC's development trajectory and market perception.

16 Apr

3

Wall Street analysts forecast a 137.88% rally for Bicycle Therapeutics (BCYC) stock and provide trading strategies. Analyst predictions of 137.88% upside signal moderately noticeable boost to investor sentiment and short-term stock performance.

4 Apr

3

RBC Capital lowered its price target on Bicycle Therapeutics plc (BCYC) to $7 from $11. RBC Capital's price target cut from $11 to $7 signals bearish outlook that could moderately impact BCYC's market sentiment and valuation.

24 Mar

4

Bicycle Therapeutics (BCYC) shares plunged 20.2% over four weeks, but technical indicators, undervaluation, and positive clinical developments signal a potential trend reversal. Optimistic outlook on reversal after sharp decline could significantly boost investor sentiment and alter short-term trajectory.

17 Mar

3

Bicycle Therapeutics reported recent business progress and released fourth quarter and full-year 2025 financial results. Financial results and business progress updates moderately influence stock performance and investor sentiment.

13 Mar

3

Bicycle Therapeutics (BCYC) appoints Travis Thompson as CFO following recent leadership transitions. CFO appointment after leadership changes moderately affects financial strategy and investor sentiment.

3 Feb

4

Bicycle Therapeutics PLC has announced leadership transitions aimed at advancing its oncology pipeline. The company is focusing on innovation and strategic growth as it prepares for the next phase of development in its therapeutic offerings. These changes are expected to enhance the company's capabilities and drive future progress in its oncology initiatives. Leadership transitions indicate a strategic shift that could significantly impact the company's innovation and market positioning.

12 Jan

4

Bicycle Therapeutics PLC highlighted its accomplishments in 2025 and outlined strategic priorities for 2026, focusing on advancing its proprietary bicyclic peptide platform and expanding its pipeline of therapeutics. The company aims to enhance its collaborations and drive innovation in drug development, positioning itself for growth in the biopharmaceutical sector. Strategic priorities and advancements in the therapeutic pipeline are likely to significantly impact future performance and investor sentiment.

16 Dec

4

Bicycle Therapeutics PLC has established multiple strategic partnerships aimed at creating an end-to-end supply chain to support its wholly owned radiopharmaceutical pipeline. These collaborations are expected to enhance the company's capabilities in developing and delivering innovative therapies, thereby strengthening its market position in the radiopharmaceutical sector. Strategic partnerships that enhance supply chain capabilities are likely to significantly impact future performance and investor sentiment.

28 Nov

4

Bicycle Therapeutics PLC is focusing on advancing its growth plans, particularly in the development of its proprietary bicyclic peptide platform. The company aims to enhance its pipeline of therapeutics targeting various diseases, including cancer. Recent collaborations and funding efforts are expected to support these initiatives, positioning Bicycle Therapeutics for potential market expansion and increased investor interest. Analysts are closely monitoring the company's progress and strategic decisions as it seeks to capitalize on its innovative technology. Significant strategic moves and potential product developments could alter the company's trajectory and investor sentiment.

26 Nov

3

European equities traded in the US, particularly American Depositary Receipts (ADRs), saw a significant surge in trading on Wednesday. This trend reflects growing investor interest in foreign companies listed in the US market, including Bicycle Therapeutics PLC Sponsored ADR (BCYC). The increase in ADR trading volumes indicates a potential shift in market dynamics, with investors seeking exposure to international equities amid changing economic conditions. Increased trading activity in ADRs may moderately influence investor sentiment and market positioning for BCYC.

1 Nov

3

Bicycle Therapeutics PLC (BCYC) is experiencing accelerated losses, reporting a 31.4% annual increase in losses. The company's revenue growth narrative is under scrutiny as it faces challenges in maintaining investor confidence and achieving sustainable financial performance. Accelerating losses and scrutiny over revenue growth could moderately influence investor sentiment and financial performance.

30 Oct

4

Bicycle Therapeutics PLC reported its third quarter 2025 financial results, highlighting recent business progress and developments in its pipeline. The company continues to advance its proprietary bicyclic peptide platform, focusing on innovative therapies for various diseases. Financial results indicate growth in revenue and investments in research and development, reflecting the company's commitment to expanding its therapeutic offerings and market presence. Recent business progress and financial results indicate significant advancements in product development and market strategy.

1 Oct

3

Bicycle Therapeutics PLC Sponsored ADR (BCYC) experienced a surge in trading alongside other European equities listed as American Depositary Receipts (ADRs) on Wednesday. The uptick in trading activity reflects a broader trend in the market, with investors showing increased interest in European companies. This movement may indicate a shift in market sentiment towards international equities, particularly those in the biotech sector, where BCYC operates. Increased trading activity in European ADRs may moderately influence market sentiment and investor interest in BCYC.

12 Sep

4

Bicycle Therapeutics PLC (NASDAQ:BCYC) has garnered significant interest from institutional investors, who collectively hold a substantial 45% stake in the company. This level of institutional ownership indicates a strong confidence in Bicycle Therapeutics' potential and future performance in the biotechnology sector. The substantial institutional ownership suggests significant investor confidence, which could influence market sentiment and the company's future trajectory.

8 Sep

4

Analysts have expressed positive sentiments regarding Bicycle Therapeutics PLC (BCYC) following its Q2 results, highlighting the company's progress and potential in the biopharmaceutical sector. The results indicate advancements in their pipeline and a strong financial position, which could enhance investor confidence and market performance. Analysts anticipate that these developments may lead to increased interest from investors and a favorable outlook for the company's future endeavors. Positive analyst sentiment following Q2 results suggests significant potential for future growth and market performance.

3

Bicycle Therapeutics PLC has announced the strengthening of its Board of Directors with new appointments aimed at enhancing its strategic direction and governance. The new members bring extensive experience in biotechnology and corporate leadership, which is expected to support the company's growth and innovation in developing therapies based on its proprietary bicyclic peptide platform. The appointments are likely to influence the company's strategic direction and governance, impacting its competitive positioning and innovation efforts.

29 Aug

4

Bicycle Therapeutics PLC is advancing its Bicycle Toxin Conjugates, which are expected to show significant therapeutic potential in treating various cancers. The company is currently engaged in multiple clinical trials aimed at evaluating the efficacy and safety of these conjugates. As the market for targeted therapies grows, Bicycle Therapeutics is exploring global commercialization pathways to maximize the impact of its innovative treatments by 2025. The development of Bicycle Toxin Conjugates and ongoing clinical trials are likely to significantly influence the company's future performance and market position.

13 Aug

3

Analysts have reduced their earnings estimates for Bicycle Therapeutics PLC (NASDAQ:BCYC), indicating a potential decline in expected financial performance. This adjustment reflects concerns about the company's future growth prospects and market conditions affecting its operations. Investors should be aware of these changes as they may influence market sentiment and the stock's performance moving forward. Analysts cutting estimates suggests a moderate impact on financial performance and market sentiment.

10 Aug

3

Bicycle Therapeutics PLC (NASDAQ: BCYC) has seen a reduction in consensus estimates for its financial performance in 2025. Analysts have adjusted their forecasts, reflecting a more cautious outlook on the company's future earnings potential. This revision may influence investor sentiment and market perception of the company's growth trajectory. The lowered estimates indicate a moderately noticeable influence on the company's financial performance and market positioning.

8 Aug

3

Bicycle Therapeutics PLC reported its recent business progress and financial results for the second quarter of 2025, highlighting advancements in its therapeutic pipeline and financial performance metrics. The company continues to focus on developing its proprietary bicyclic peptide platform, which is aimed at addressing unmet medical needs in various diseases. Key financial figures were disclosed, showcasing revenue growth and investment in research and development efforts. The report reflects the company's strategic direction and commitment to innovation in the biopharmaceutical sector. The financial results and business progress indicate a moderate influence on the company's performance and market sentiment.

14 Jun

3

Bicycle Therapeutics (NASDAQ:BCYC) has a cash runway of approximately 4.4 years, with zero debt and cash reserves of US$793 million against a cash burn of US$182 million. However, the company increased its cash burn by 112% in the last year while experiencing a 38% drop in operating revenue, raising concerns about its growth trajectory. With a market capitalization of US$602 million, the cash burn represents about 30% of its market value, indicating potential dilution if new shares are issued to raise funds. Shareholders are advised to monitor the company's cash burn closely. The significant increase in cash burn alongside declining revenue suggests potential challenges in financial performance and growth.

3 Jun

3

Bicycle Therapeutics PLC has announced inducement grants under Nasdaq Listing Rule 5635(c)(4). These grants are part of the company's strategy to attract and retain key personnel, aligning with its growth objectives. The inducement grants are expected to enhance the company's ability to drive innovation and advance its therapeutic pipeline. Inducement grants can influence talent acquisition and retention, which may moderately affect the company's operational effectiveness and innovation capacity.

22 May

3

Bicycle Therapeutics PLC announced that it will present posters at the 2025 ASCO Annual Meeting, showcasing its latest research and developments in the field of oncology. The presentations are expected to highlight the company's innovative therapeutic approaches and advancements in its pipeline, aimed at improving patient outcomes in cancer treatment. The poster presentations may enhance visibility and interest in the company's research, potentially influencing investor sentiment and market performance.

5 May

4

Bicycle Therapeutics plc (NASDAQ:BCYC) is highlighted as a top small-cap stock with significant upside potential, boasting a market cap of $627.08 million and an analyst upside of 244.63%. The company, focused on developing innovative therapies for underserved diseases, has a strong financial position with $793 million in cash reserves, allowing it to advance its clinical programs. Analyst Swayampakula Ramakanth maintained a Buy rating, citing promising advancements in its pipeline, particularly in cancer imaging. Despite its potential, the article notes that some AI stocks may offer higher returns in a shorter timeframe. Bicycle Therapeutics' promising advancements and strong financial position could significantly impact its future performance and investor sentiment.

stockrow.com/BCYC · Data as of Jun 30, 2026 · For information only; not investment advice. · © 2026 stockrow.com