Sionna Therapeutics, Inc.

SION

Healthcare Biotechnology

EPS
−61.0%
Free cash flow
−22.4%

Quarter to June 2026, against a year earlier

3.28 0.00 0.00%
Market cap
$148.3M
P/E
n/m
Fwd P/E
—
Dividend yield
—
F-score
n/a
ROIC
−125.0%
Net debt / EBITDA
2.6×
Dividend safety
n/a

Insider Decisions last twelve months

Net sold
$134.8M
Trades
23 sells · 0 buys
Ownership
47.8%

Capital & Financial Ratios $m

Size
Market Cap 148
Revenue ttm —
Net income ttm (97)
Free cash flow ttm (76)
Net debt Q (211)
Valuation
P/E n/m
Forward P/E —
Price / sales n/m
Forward P/S Powerpack
Price / FCF n/m
Price / book 0.6
Financial health
Current ratio Q 20.0 (at or above 1.5: strong)
Debt / equity Q n/m
Interest coverage Q —
Growth
Revenue growth Q —
Operating income growth Q −48.2% (below 0%: shrinking)
EPS, this year −31.9% (below 0%: weak)
EPS, next year A +7.5%
Revenue, next year A —
EPS, past 5 yrs —
EPS, next 5 yrs A −11.4% (below 0%: weak)

Green and red mark values outside typical ranges; (Q) is the latest quarter, (A) analysts’ estimates; n/m is not meaningful, as a P/E on a loss. How we judge →

Valuation vs history

Dividends

Yield
—
Annual rate
—
Payout ratio
—

Assets vs Liabilities $m

2023 2024 2025 Q'26
Cash 39 148 236 211
Receivables — — — —
Inventory — — — —
Other — — — —
39 151 241 216
2023 2024 2025 Q'26
Payables 1 1 1 1
ST’ Debt — — — —
Other — — 0 0
8 10 12 11

Compound Annual Growth %

10y 5y 3y
Sales — — —
Cash Flow — — —
Earnings — — —
Book Value — — —

Earnings Trends EPS, adjusted, against the consensus

EPS $

Mar Jun Sep Dec Year
’26 (0.60) (0.66) — — —
’25 (0.62) (0.41) (0.46) (0.46) (1.88)
’24 (3.84) (2.71) (5.67) (3.38) (15.99)
Fiscal quarters ending in the months shown.

Revenue $m

Year
Fiscal quarters ending in the months shown.

Operating Cash Flow $m

Mar Jun Sep Dec Year
’26 (22) (22) — — —
’25 (16) (18) (15) (17) (66)
’24 (13) (10) (18) (12) (53)
Fiscal quarters ending in the months shown.

Free Cash Flow $m

Mar Jun Sep Dec Year
’26 (22) (22) — — —
’25 (16) (18) (15) (17) (67)
’24 (13) (10) (18) (12) (53)
Fiscal quarters ending in the months shown.

Target Price Range

Analyst price targets

Recommendation Rating

2.8
1Buy 2 3Hold 4 5Sell

Ten years at a glance

Ten-year view Analyst estimates Powerpack
Group Line 2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 TTM Jun ’26 Trend 10 yrs 2026e 2027e 2028e Next 3/yr
Income, $m
Income, $m Revenue — — — — — — — — — — — — — — 2 —
Gross margin, % — — — — — — — — — — — —
EBT — — — — — — — (47) (62) (75) (97) +26.2%
EBT margin, % — — — — — — — 0.00 0.00 0.00 0.00 0.0 pt
Net income — — — — — — — (47) (62) (75) (97) +26.2%
Per share, $
Per share, $ Revenue — — — — — — — 0.00 0.00 0.00 0.00 n/m
Earnings — — — — — — — (16.11) (15.99) (1.88) (2.18) (65.8%)
Cash flow — — — — — — — (14.90) (13.68) (1.66) (1.68) (66.6%)
Capex — — — — — — — (0.38) (0.01) (0.01) 0.00 (84.3%)
Free cash flow — — — — — — — (15.28) (13.69) (1.67) (1.68) (67.0%)
Book value — — — — — — — (39.17) (42.42) 7.68 5.89 n/m
Shares, m — — — — — — — 3 4 40 44 +269.1%
Valuation, ×
Valuation, × P/E — — — — — — — — — — 0 —
P/S — — — — — — — — — — 0 —
P/B — — — — — — — — — — 0 —
EV/Sales — — — — — — — — — — 0 —
EV/FCF — — — — — — — — — — 0 —
Cash, $m
Cash, $m Operating cash flow — — — — — — — (44) (53) (66) (76) +23.2%
Capex — — — — — — — (1) 0 0 0 (41.9%)
Free cash flow — — — — — — — (45) (53) (67) (76) +22.0%
Balance, $m
Balance, $m Working capital — — — — — — — 31 141 230 205 +171.5%
Net debt — — — — — — — (39) (148) (236) (211) +147.5%
Shareholders’ equity — — — — — — — (115) (164) 307 266 n/m
Returns, %
Returns, % ROA — — — — — — — 0.00 (51.90) (29.42) (30.66) (29.4) pt
ROIC — — — — — — — 0.00 0.00 (78.38) (125.00) (78.4) pt
ROE — — — — — — — 0.00 44.29 (105.18) (32.34) (105.2) pt
People
People Employees — — — — — — — 35 41 59 — +29.8%
Revenue/emp, $m — — — — — — — 0.00 0.00 0.00 — n/m
Negative figures in brackets.
estimates

All 10 years →

Sionna Therapeutics, Inc. vs peers in Biotechnology (Q) = latest quarter vs a year earlier

Company Market cap P/E Fwd P/E Revenue growth (Q) EPS growth (Q) FCF growth (Q) Gross margin (Q) EBIT margin (Q) Compare
CNTN Canton Strategic Holdings, Inc. $164.1M — (loss-making) — — n/m −600.39% (below 0%: shrinking) 100.00% (80.37%) Compare
IPHA Innate Pharma S.A. Sponsored ADR $160.9M — (loss-making) — +246.29% (above 0%: growing) +106.08% (above 0%: growing) −929.03% (below 0%: shrinking) 0.00% 0.00% Compare
STRO Sutro Biopharma, Inc. $159.5M — (loss-making) — (loss-making) −84.57% (below 0%: shrinking) n/m +14.55% (above 0%: growing) 100.00% (303.77%) Compare
ANTX AN2 Therapeutics, Inc. $150.9M — (loss-making) — — n/m +7.91% (above 0%: growing) 0.00% 0.00% Compare
MGNX MacroGenics, Inc. $148.4M — (loss-making) — (loss-making) +47.62% (above 0%: growing) n/m +12.88% (above 0%: growing) 100.00% (42.19%) Compare
SION Sionna Therapeutics, Inc. $148.3M — (loss-making) — — n/m −22.40% (below 0%: shrinking) — 0.00%
NGEN NervGen Pharma Corp. $143.1M — (loss-making) — — n/m −48.10% (below 0%: shrinking) — 0.00% Compare
VRXA Veraxa Biotech AG $140.4M — — — — — — — Compare
INO Inovio Pharmaceuticals, Inc. $125.6M — (loss-making) — (loss-making) −83.19% (below 0%: shrinking) n/m +13.41% (above 0%: growing) 100.00% 0.00% Compare
Median of peers $149.7M — — −17.78% — +7.91% 100.00% 0.00%

All 621 Biotechnology stocks →

Pay and ownership Proxy statement filed 27 April 2026

Ownership

Directors and executive officers, together 5.10%
Entities affiliated with RA Capital, L.P. 22.30%
Entities affiliated with TPG Growth 14.80%
Atlas Venture Fund XI, L.P 6.80%
OrbiMed Private Investments VIII, L.P. 6.60%
Entities affiliated with Viking Global Opportunities 6.50%
Sionna Aggregator, LP 5.50%
Ownership is the proxy’s own table: the directors and officers as a group, and every holder of 5% or more. Read the proxy statement

Sionna Therapeutics, Inc. (SION) Latest News

15 Sep

14 May

Impact 3 · · Insider Monkey

12 May

2 Mar

Impact 3 · · GlobeNewswireGuruFocus.comZacksMarketBeatGuruFocus.comGuruFocus.comMobyMarketBeat
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