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Sionna Therapeutics, Inc. (SION) vs Upstream Bio, Inc. (UPB)

Sionna Therapeutics, Inc. and Upstream Bio, Inc. are both Biotechnology companies. Sionna Therapeutics, Inc. and Upstream Bio, Inc. are of similar size ($184.6M and $184.5M). Sionna Therapeutics, Inc. has the higher net margin (0.00% vs −4,955.7%) and the higher return on invested capital (−125.0% vs −1,100.9%). Across the 13 metrics below, Sionna Therapeutics, Inc. leads on 10 and Upstream Bio, Inc. on 3.

Valuation

Metric SION UPB Biotechnology median
P/E n/m n/m 8.50
P/S n/m 47.69 9.71
P/B 0.66 0.56 2.13
Price to free cash flow n/m n/m 20.82
EV/EBITDA 0.32 0.65 0.64
EV/Sales n/m (35.05) 9.21
Earnings yield (56.04%) (105.07%) (33.15%)
Free cash flow yield (43.44%) (90.76%) (25.50%)

Profitability

Metric SION UPB Biotechnology median
Gross margin — 100.00% 65.16%
Operating margin 0.00% (5,382.65%) 0.00%
Net margin 0.00% (4,955.67%) 0.00%
Free cash flow margin 0.00% (4,317.42%) 0.00%
Return on equity (32.34%) (46.05%) (56.36%)
Return on assets (30.66%) (44.61%) (48.04%)
Return on invested capital (125.00%) (1,100.93%) 0.00%

Growth

Metric SION UPB Biotechnology median
Revenue growth (TTM) — 15.98% 6.02%
EPS growth (last fiscal year) 88.24% 52.33% 30.26%
Revenue growth, 5-year CAGR — — 9.41%
Net income growth, 5-year CAGR — — 0.00%

Health

Metric SION UPB Biotechnology median
Debt to equity 0.00 0.00 0.00
Current ratio 20.05 27.99 4.72
Net debt to EBITDA 2.58 2.11 0.96

Dividend

Metric SION UPB Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric SION UPB Biotechnology median
Market cap 184.47m 184.58m 135.18m

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