Amylyx Pharmaceuticals, Inc. AMLX

29.49 (0.65) (2.16%) as of 25 Sep
Market cap
$3.8B
P/E
0.0×
Insider Buys alert about insiders buying in the last 12 month

Insider Decisions

Total buys 0.15
Total sells 9.30
in millions of $
Nov 25 Feb 26 May 26 Aug 26
Buy — — 1 — — — — 1 — — — —
Sell — — 1 5 5 5 — — — 1 — 5
Insider Ownership 4.43%

Capital & Financial Ratios

Market Cap 3,780.00
Revenue 87.37
Net Income (152.09)
Free Cash Flow (130.72)
Net Debt (250.76)
Current Ratio 12.12
Debt/Equity 0.00
P/E ratio 0.00
P/S ratio 37.53
P/B ratio 13.71
Past 5Y EPS Growth (78.71%)
This Y EPS Growth 1.51%
Next Y EPS Growth 21.46%
Next 5Y EPS Growth 44.87%
in millions of $

Dividends

Payout Ratio 0.00
Annual Dividend Rate —
Annual Dividend Yield —
total individual payouts
2025 Powerpack
2024 Powerpack
2023 Powerpack
2022 Powerpack
2018 0.42
0.42
2017 0.60
0.24
0.36
predictions in italic, special payouts not included in total or ratios

Assets vs Liabilities

2023 2024 2025 Q'26
Cash 371 177 317 251
Receivables 40 0 0 —
Inventory 38 — — —
Other — — — —
465 189 324 256
2023 2024 2025 Q'26
Payables 22 3 4 6
ST’ Debt — — — —
Other — — — —
82 28 23 21
in millions of $

Compound Annual Growth

10y 5y 3y
Sales — — 574.28%
Cash Flow — 0.00% 0.00%
Earnings — 0.00% 0.00%
Book Value — 124.63% (3.59%)

Revenue

Mar Jun Sep Dec Year
’26 — — — — —
’24 89 — 0 — 87
’23 71 98 103 108 381
’22 — — 0 22 22
’21 — — 0 — 0
in millions of $ · fiscal quarters ending in the months shown
value withheld pending a data check

Operating Cash Flow

Mar Jun Sep Dec Year
’26 (37) (31) — — —
’25 (40) (25) (30) (28) (123)
’24 0 (67) (42) (59) (168)
’23 (5) 9 (5) 14 12
’22 (41) (46) (43) (50) (180)
’21 (13) (13) (21) (28) (75)
in millions of $ · fiscal quarters ending in the months shown

Free Cash Flow

Mar Jun Sep Dec Year
’26 (41) (31) — — —
’25 (40) (25) (30) (28) (123)
’24 (1) (67) (78) (59) (204)
’23 (5) 8 (6) 13 11
’22 (41) (48) (44) (50) (182)
’21 (13) (13) (21) (28) (75)
in millions of $ · fiscal quarters ending in the months shown

EPS

Mar Jun Sep Dec Year
’26 (0.37) (0.39) — — —
’25 (0.42) (0.46) (0.37) (0.30) (1.53)
’24 (1.75) (1.07) (1.07) (0.55) (4.43)
’23 0.02 0.31 0.30 0.07 0.70
’22 (0.93) (0.93) (0.92) (0.65) (3.39)
’21 (2.33) (3.41) (3.42) (4.19) (13.35)
fiscal quarters ending in the months shown

Target Price Range

Analyst price targets

Recommendation Rating

1.3
1Buy 2 3Hold 4 5Sell
2016 2017 2018 2019 2020 2021 2022 2023 2024 2025 2026 2027 2028
— — — — — — 6.51 11.82 1.58 2.60

Analyst estimates 2026–2028

Powerpack
Low Price
— — — — — — 39.78 41.93 19.95 16.96
High Price
— — — — 110 205 262 384 123 136
Employees
— — — — 0 0 0 1 1 0
Revenue/Emp
— — — — 1 0 22 381 87 —
Revenue
— — — — 100.00% 100.00% 86.54% 93.32% (42.65%) —
Gross Margin
— — — — (42) (88) (198) 54 (302) (145)
EBT
— — — — (6,504.62%) (30,852.98%) (888.89%) 14.26% (345.81%) 0.00%
EBT Margin
— 0 — — (42) (88) (198) 49 (302) (145)
Net Income
— — — — 0 0 (2) (9) (9) (5)
Depreciation
— — — — 0.11 0.04 0.38 5.66 1.28 0.00
Revenue/Sh
— — — — (6.96) (13.35) (3.39) 0.73 (4.43) (1.53)
Earnings/Sh
— — — — (6.04) (11.36) (3.07) 0.18 (2.46) (1.30)
Cash Flow/Sh
— — — — (0.02) (0.05) (0.04) (0.02) (0.53) 0.00
Capex/Sh
— — — — (6.06) (11.41) (3.12) 0.16 (2.99) (1.31)
Free CF/Sh
— — — — 0.88 13.39 5.82 6.45 2.42 3.23
Book Value/Sh
— — — — 6 7 58 67 68 95
Shares
— — — — 0.00 0.00 0.00 20.51 0.00 —
PE Ratio
— — — — 0.00 0.00 0.00 2.64 2.95 —
PS Ratio
— — — — 0.00 0.00 6.18 2.32 1.56 —
PB Ratio
— — — — 0.00 0.00 0.00 1.67 0.94 —
EV/Sales
— — — — (0.32) (0.32) (9.64) 59.61 (0.40) —
EV/FCF
— — — — (37) (75) (180) 12 (168) (123)
Op' Cash Flow
— — — — 0 0 (3) (1) (36) 0
Capex
— — — — (37) (75) (182) 11 (204) (123)
FCF
— — — — 6 88 336 383 161 301
Working Cap'
— — — — 1 — — — — —
Total Debt
— — — — (11) (96) (347) (371) (177) (317)
Net Debt
— — — — 5 88 341 433 165 305
Sh' Equity
— — — — (599.55%) (146.90%) (79.82%) 10.84% (84.87%) (55.00%)
ROA
— — — — 0.00% 0.00% 0.00% 39.07% 0.00% 0.00%
ROIC
— — — — 0.00% 80.71% (209.43%) 12.73% (100.88%) (61.59%)
ROE
predictions in italic, sparklines do not include predictions

All 10 years →

Fiscal years to Dec 2024 · latest quarter Dec 2024

Amylyx Pharmaceuticals, Inc. (AMLX) key facts

  • Amylyx Pharmaceuticals, Inc. (AMLX) is a Drug Manufacturers Specialty & Generic company in the Healthcare sector, listed on Nasdaq.
  • Amylyx Pharmaceuticals, Inc. reported a net loss of $144.7 million, or a loss of $1.53 per share, for fiscal 2025.
  • As of September 25, 2026, AMLX traded at $29.49, a market capitalization of $3.8 billion.
  • Trailing earnings are negative, so a P/E ratio is not meaningful; the stock trades at 37.5× sales.
  • Return on equity was −61.6% and debt-to-equity 0.00.

Source: company filings (standardised) and stockrow calculations.

Amylyx Pharmaceuticals, Inc. (AMLX) Latest News

News by impact score

Fine-tune

1 Sep

4

Amylyx Pharmaceuticals (AMLX) stock surged 247% on GLP-1 developments, prompting debate on whether shares remain a buy after the sharp rally. 247% stock surge reflects major market reaction capable of shifting valuation, sentiment and future trajectory.

21 Aug

5

Amylyx faces a decisive Phase 3 trial for Avexitide that will determine whether the drug can revive the company after prior setbacks. Binary Phase 3 result for Avexitide will dictate whether the company rebuilds or loses its main recovery path.

4

Amylyx Pharmaceuticals shares surged nearly 79% this week on major positive developments affecting its pipeline and market position. Stock surge of this magnitude signals major strategic or regulatory progress likely to reshape near-term valuation and investor outlook.

19 Aug

4

Amylyx Pharmaceuticals (AMLX) stock rises after Avexitide wins its Phase III study and nears regulatory filing by end of 2026. Phase III win for Avexitide advances Amylyx toward potential approval and new revenue streams.

4

Amylyx Pharmaceuticals reported a positive Phase 3 result for Avexitide and followed with an equity raise. Phase 3 win advances Avexitide toward approval and equity raise supplies development capital.

3

Amylyx Pharmaceuticals priced an upsized $500 million underwritten public offering of common stock. The $500 million raise bolsters cash reserves but increases share dilution and pressures near-term stock performance.

18 Aug

5

Amylyx Pharmaceuticals GLP-1 drug succeeds in late-stage trial, driving sharp rise in AMLX stock price. Positive late-stage trial outcome for GLP-1 drug opens major commercial opportunity and fundamentally boosts long-term prospects.

5

Amylyx Pharmaceuticals stock surged 55% after its GLP-1 blocker met all trial goals. GLP-1 blocker trial success positions Amylyx for major market gains and strategic advancement.

5

Amylyx Pharmaceuticals Phase 3 LUCIDITY Trial for Avexitide met its primary endpoint. Phase 3 primary endpoint success for Avexitide enables regulatory approval path and long-term revenue potential.

5

Amylyx Pharmaceuticals stock surged 45% after its GLP-1 blocker met all trial endpoints. Successful GLP-1 blocker trial success drives 45% stock surge and opens major new market opportunity.

4

Amylyx Pharmaceuticals (AMLX) stock reaches new highs as Avexitide advances toward commercialization. Avexitide progress toward commercialization signals major pipeline advancement with strong potential to drive revenue and shift company trajectory.

4

Amylyx Pharmaceuticals (AMLX) stock surged sharply today. Sharp stock price increase signals major positive development likely to alter near-term trajectory and sentiment.

4

AMLX stock achieves record gains on positive trial data and launches $350M offering. Positive trial data drives major stock gains and funds further development for Amylyx.

4

Amylyx Pharmaceuticals stock surges after avexitide succeeds in Phase 3 trial. Successful Phase 3 trial for avexitide signals major regulatory and commercial upside for AMLX.

4

Amylyx Pharmaceuticals stock surged 50% after its GLP-1 blocker met all trial goals. Successful GLP-1 blocker trial results drive 50% stock surge and open major growth path for the company.

4

Amylyx Pharmaceuticals' Phase III Avexitide trial cut severe hypoglycemic events by 55%. Phase III success for Avexitide signals major pipeline progress and potential new revenue.

4

Amylyx Pharmaceuticals explores new GLP-1 applications, driving its stock to a three-year high. New GLP-1 use at Amylyx points to major strategic expansion with direct effects on market trajectory and investor outlook.

4

Amylyx Pharmaceuticals stock surged 33% after its GLP-1 blocker met all trial endpoints. Positive GLP-1 blocker trial success triggered 33% stock surge and signals major upside for company trajectory.

4

Amylyx Pharmaceuticals stock surged 32% after its GLP-1 blocker met all clinical trial goals. Successful GLP-1 blocker trial directly drove major stock gain and opens significant new revenue path.

4

Amylyx Pharmaceuticals announced positive topline results from its Phase 3 LUCIDITY trial of avexitide for post-bariatric hypoglycemia. Positive Phase 3 results for avexitide advance potential approval and new revenue stream in post-bariatric hypoglycemia.

4

Amylyx Pharmaceuticals succeeds with its GLP-1 blocker strategy, delivering positive results that strengthen the company's development efforts and market outlook. Amylyx's GLP-1 blocker success marks a major strategic win that can substantially improve pipeline value and investor sentiment.

3

Amylyx Pharmaceuticals announces a proposed $350 million public offering of common stock. The capital raise supplies operational funding but introduces share dilution that can pressure near-term stock performance.

17 Aug

4

Amylyx Pharmaceuticals will announce topline results from its Phase 3 LUCIDITY trial of Avexitide in post-bariatric hypoglycemia on August 18, 2026. Phase 3 trial results for a lead drug candidate can substantially alter a biotech company's valuation, development path, and market position.

3

AMLX shares jumped 14% in after-hours trading. After-hours price surge signals short-term positive sentiment without details on fundamental or lasting business changes.

15 Aug

4

Amylyx Pharmaceuticals (AMLX) stock trades at a premium after progress in the Avexitide trial. Avexitide trial progress drives AMLX stock premium trading and signals major trajectory shift.

14 Aug

3

Amylyx Pharmaceuticals stock fell 7.1% after reporting a wider Q2 loss and providing an Avexitide Phase III update. Wider quarterly losses and Phase III updates can shift near-term investor sentiment and affect operational focus without fundamentally redefining long-term prospects.

13 Aug

3 transcript

Amylyx Pharmaceuticals, Inc. (AMLX) released its Q2 2026 earnings call transcript. Quarterly earnings call provides financial results and guidance that can shift near-term investor sentiment and stock movement.

6 Aug

4 transcript

Amylyx Pharmaceuticals highlighted pipeline progress and advancement toward pivotal clinical milestones during its Q2 2026 earnings call. Pipeline advancement toward pivotal trials signals major potential shifts in regulatory and commercial trajectory.

3

Amylyx Pharmaceuticals Q2 earnings call highlighted financial results, operational updates and strategic outlook for the company. Q2 earnings highlights deliver financial and operational updates that moderately affect performance and investor sentiment.

30 Jun

4

Amylyx Pharmaceuticals stock faces potential breakout on upcoming LUCIDITY trial data release. Key clinical trial data can substantially shift Amylyx market trajectory and investor sentiment.

stockrow.com/AMLX · Data as of Dec 31, 2024 · For information only; not investment advice. · © 2026 stockrow.com