Ionis Pharmaceuticals, Inc. (IONS) vs TG Therapeutics, Inc. (TGTX)

Ionis Pharmaceuticals, Inc. and TG Therapeutics, Inc. are both Biotechnology companies. TG Therapeutics, Inc. is the larger, with a market value of $8.8B against $7.4B — 1.2× the size. Ionis Pharmaceuticals, Inc. has negative trailing earnings, so its P/E is not meaningful; TG Therapeutics, Inc. trades at 18.9×. TG Therapeutics, Inc. grew revenue faster over the last twelve months: 76.1% against −7.41%. TG Therapeutics, Inc. has the higher net margin (55.2% vs −64.7%) and the higher return on invested capital (10.7% vs 0.00%). Across the 18 metrics below, TG Therapeutics, Inc. leads on 14 and Ionis Pharmaceuticals, Inc. on 4.

Valuation

Metric IONS TGTX Biotechnology median
P/E n/m 18.89 7.88
P/S 8.42 10.18 11.47
P/B 16.74 13.48 2.52
Price to free cash flow n/m 468.33 21.16
EV/EBITDA n/m 61.31 0.74
EV/Sales 8.11 10.43 10.73
Earnings yield (7.78%) 5.29% (28.84%)
Free cash flow yield (7.71%) 0.21% (23.03%)

Profitability

Metric IONS TGTX Biotechnology median
Gross margin 98.17% 82.37% 65.16%
Operating margin (68.00%) 17.05% 0.00%
Net margin (64.66%) 55.22% 0.00%
Free cash flow margin (64.93%) 2.17% 0.00%
Return on equity (105.50%) 100.28% (57.72%)
Return on assets (18.90%) 37.70% (49.22%)
Return on invested capital 0.00% 10.69% 0.00%

Growth

Metric IONS TGTX Biotechnology median
Revenue growth (TTM) (7.41%) 76.08% 5.64%
EPS growth (last fiscal year) 21.71% 1,746.67% —
Revenue growth, 5-year CAGR 5.29% 426.73% 8.40%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric IONS TGTX Biotechnology median
Debt to equity 3.07 1.23 0.00
Current ratio 7.89 4.27 4.73
Net debt to EBITDA 2.39 0.86 0.96

Dividend

Metric IONS TGTX Biotechnology median
Dividend yield — — 2.10%
Payout ratio 0.00 0.00 0.00

Size

Metric IONS TGTX Biotechnology median
Market cap 7.39b 8.80b 162.10m

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