Ionis Pharmaceuticals, Inc. (IONS) vs Iovance Biotherapeutics, Inc. (IOVA)

Ionis Pharmaceuticals, Inc. and Iovance Biotherapeutics, Inc. are both Biotechnology companies. Ionis Pharmaceuticals, Inc. and Iovance Biotherapeutics, Inc. are of similar size ($7.3B and $6.7B). Iovance Biotherapeutics, Inc. grew revenue faster over the last twelve months: 34.6% against −7.41%. Ionis Pharmaceuticals, Inc. has the higher net margin (−64.7% vs −89.1%) and the higher return on invested capital (0.00% vs −43.0%). Across the 17 metrics below, Ionis Pharmaceuticals, Inc. leads on 10 and Iovance Biotherapeutics, Inc. on 7.

Valuation

Metric IONS IOVA Biotechnology median
P/E n/m n/m 8.50
P/S 8.13 18.81 9.71
P/B 16.15 8.31 2.13
Price to free cash flow n/m n/m 20.82
EV/EBITDA n/m n/m 0.64
EV/Sales 7.82 17.90 9.21
Earnings yield (8.06%) (5.38%) (33.15%)
Free cash flow yield (7.99%) (4.85%) (25.50%)

Profitability

Metric IONS IOVA Biotechnology median
Gross margin 98.17% 48.40% 65.16%
Operating margin (68.00%) (92.72%) 0.00%
Net margin (64.66%) (89.09%) 0.00%
Free cash flow margin (64.93%) (91.21%) 0.00%
Return on equity (105.50%) (40.36%) (56.36%)
Return on assets (18.90%) (31.76%) (48.04%)
Return on invested capital 0.00% (42.96%) 0.00%

Growth

Metric IONS IOVA Biotechnology median
Revenue growth (TTM) (7.41%) 34.55% 6.02%
EPS growth (last fiscal year) 21.71% 14.84% 30.26%
Revenue growth, 5-year CAGR 5.29% — 9.41%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric IONS IOVA Biotechnology median
Debt to equity 3.07 0.00 0.00
Current ratio 7.89 4.35 4.72
Net debt to EBITDA 2.39 0.82 0.96

Dividend

Metric IONS IOVA Biotechnology median
Dividend yield — — 0.09%
Payout ratio — — —

Size

Metric IONS IOVA Biotechnology median
Market cap 7.33b 6.67b 135.18m

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