Powerpack

Unlock full stockrow access for only $9.90/month and boost yourself as an investor.

  • Full quarterly history

    Every quarter and TTM period we hold, not just the last 12.

  • Analyst estimates

    Three years of forward estimates and dividend forecasts.

  • Unlimited screener

    All results, unlimited saved screens, email when a screen changes.

  • Unlimited Excel

    Full workbooks and screener exports.

  • Unlimited follows

See Powerpack
Screener Weekly Summary Pricing

Ionis Pharmaceuticals, Inc. (IONS) vs Spyre Therapeutics, Inc. (SYRE)

Ionis Pharmaceuticals, Inc. and Spyre Therapeutics, Inc. are both Biotechnology companies. Ionis Pharmaceuticals, Inc. and Spyre Therapeutics, Inc. are of similar size ($7.7B and $7.4B). Ionis Pharmaceuticals, Inc. grew revenue faster over the last twelve months: −7.41% against −81.8%. Spyre Therapeutics, Inc. has the higher net margin (0.00% vs −64.7%) and the higher return on invested capital (0.00% vs 0.00%). Across the 17 metrics below, Spyre Therapeutics, Inc. leads on 11 and Ionis Pharmaceuticals, Inc. on 6.

Valuation

Metric IONS SYRE Biotechnology median
P/E n/m n/m 7.88
P/S 8.42 6,931.86 11.47
P/B 16.74 7.65 2.52
Price to free cash flow n/m n/m 21.16
EV/EBITDA n/m n/m 0.74
EV/Sales 8.11 5,845.20 10.73
Earnings yield (7.78%) (2.48%) (28.84%)
Free cash flow yield (7.71%) (2.85%) (23.03%)

Profitability

Metric IONS SYRE Biotechnology median
Gross margin 98.17% 100.00% 65.16%
Operating margin (68.00%) 0.00% 0.00%
Net margin (64.66%) 0.00% 0.00%
Free cash flow margin (64.93%) 0.00% 0.00%
Return on equity (105.50%) (28.52%) (57.72%)
Return on assets (18.90%) (20.90%) (49.22%)
Return on invested capital 0.00% 0.00% 0.00%

Growth

Metric IONS SYRE Biotechnology median
Revenue growth (TTM) (7.41%) (81.84%) 5.64%
EPS growth (last fiscal year) 21.71% 55.24% —
Revenue growth, 5-year CAGR 5.29% (28.15%) 8.40%
Net income growth, 5-year CAGR 0.00% 0.00% 0.00%

Health

Metric IONS SYRE Biotechnology median
Debt to equity 3.07 0.00 0.00
Current ratio 7.89 18.53 4.73
Net debt to EBITDA 2.39 3.61 0.96

Dividend

Metric IONS SYRE Biotechnology median
Dividend yield — — 2.10%
Payout ratio 0.00 0.00 0.00

Size

Metric IONS SYRE Biotechnology median
Market cap 7.39b 7.68b 162.10m

Compare with another peer

Any metric, up to five companies and an Excel export Powerpack